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Protein Page:
GTF2I (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GTF2I a multifunctional phosphoprotein with roles in transcription and signal transduction. Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and Phox1 and interacts cooperatively with Phox1 to promote serum-inducible transcription of a reporter gene driven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Its gene is known to contain at least 34 exons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding
Biological Process: negative regulation of angiogenesis; signal transduction; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Disease: Williams-beuren Syndrome
Reference #:  P78347 (UniProtKB)
Alt. Names/Synonyms: BAP-135; BAP135; Bruton tyrosine kinase-associated protein 135; BTK-associated protein 135; BTK-associated protein, 135kD; BTKAP1; DIWS; FLJ38776; FLJ56355; General transcription factor II-I; general transcription factor IIi; GTF2I; GTFII-I; IB291; SPIN; SRF-Phox1-interacting protein; TFII-I; WBS; WBSCR6; Williams-Beuren syndrome chromosomal region 6 protein; Williams-Beuren syndrome chromosome region 6
Gene Symbols: GTF2I
Molecular weight: 112,416 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GTF2I

Protein Structure Not Found.
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Download ChimeraX Script


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Sites Implicated In
transcription, altered: Y248‑p, Y249‑p
transcription, induced: Y248‑p, Y249‑p, S412‑p, S784‑p
activity, induced: Y248‑p, Y249‑p
intracellular localization: Y248‑p, Y249‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T8‑p MAQVAMStLPVEDEE
0 2 S16‑p LPVEDEEsSEsRMVV
0 1 S19‑p EDEEsSEsRMVVTFL
0 2 K74‑ub NTRKDFQkDFVKYCV
0 1 K86‑sm YCVEEEEkAAEMHKM
0 1 K94‑sm AAEMHKMksTTQANR
0 1 S95‑p AEMHKMksTTQANRM
0 14 S103‑p TTQANRMsVDAVEIE
0 1 T111‑p VDAVEIEtLRKTVED
0 1 K130‑sm CYGKALGkSTVVPVP
0 1 K140‑ub VVPVPYEkMLRDQsA
0 1 K140‑sm VVPVPYEkMLRDQsA
0 3 S146‑p EkMLRDQsAVVVQGL
0 2 K160‑ub LPEGVAFkHPENYDL
0 3 T202‑p VGGRVMVtDADRsIL
0 7 S207‑p MVtDADRsILsPGGs
0 25 S210‑p DADRsILsPGGsCGP
0 8 S214‑p sILsPGGsCGPIKVk
0 1 K219 GGsCGPIKVkTEPTE
1 1 K221‑sm sCGPIKVkTEPTEDS
0 1 S228 kTEPTEDSGISLEMA
0 1 T238‑p SLEMAAVtVkEESED
1 1 K240‑sm EMAAVtVkEESEDPD
8 10 Y248‑p EESEDPDyyQYNIQA
5 1 Y249‑p ESEDPDyyQYNIQAG
0 2 Y251 EDPDyyQYNIQAGPS
0 1 Y318 VTIEDDDYsPPSKRP
0 5 S319‑p TIEDDDYsPPSKRPk
0 1 K326‑sm sPPSKRPkANELPQP
0 2 A327 PPSKRPkANELPQPP
0 13 K343‑ac PEPANAGkRKVREFN
0 1 K343‑sm PEPANAGkRKVREFN
0 8 K353‑ub VREFNFEkWNARITD
0 1 K353‑sm VREFNFEkWNARITD
0 1 K372‑sm VEELFERkYAQAIkA
0 1 K378‑sm RkYAQAIkAKGPVTI
1 3 Y398‑p QSHVEDLyVEGLPEG
2 144 S412‑p GIPFRRPstYGIPRL
0 5 T413‑p IPFRRPstYGIPRLE
0 1 K435‑sm RIRFVIKkHELLNST
0 1 S441 KkHELLNSTREDLQL
0 5 K450‑ac REDLQLDkPAsGVkE
0 1 K450‑sm REDLQLDkPAsGVkE
0 2 S453‑p LQLDkPAsGVkEEWy
0 1 K456‑m1 DkPAsGVkEEWyARI
0 1 K456‑sm DkPAsGVkEEWyARI
0 6 Y460‑p sGVkEEWyARITKLR
0 1 K476‑ub MVDQLFCkkFAEALG
0 4 K477‑ub VDQLFCkkFAEALGS
0 1 K477‑sm VDQLFCkkFAEALGS
0 5 K488‑ub ALGSTEAkAVPYQkF
0 1 K488‑sm ALGSTEAkAVPYQkF
0 2 K494‑ub AkAVPYQkFEAHPND
0 1 K494‑sm AkAVPYQkFEAHPND
1 5 Y503‑p EAHPNDLyVEGLPEN
0 15 S515‑p PENIPFRsPsWyGIP
0 13 S517‑p NIPFRsPsWyGIPRL
0 1 Y519‑p PFRsPsWyGIPRLEk
0 2 K526‑ub yGIPRLEkIIQVGNR
0 1 K526‑sm yGIPRLEkIIQVGNR
0 1 K539‑ub NRIKFVIkRPELLTH
1 13 T556‑p TEVTQPRtNtPVkED
1 38 T558‑p VTQPRtNtPVkEDWN
0 8 K561‑ac PRtNtPVkEDWNVRI
0 1 K561‑ub PRtNtPVkEDWNVRI
0 1 K561‑sm PRtNtPVkEDWNVRI
0 2 S620‑p PEGIPFRsPTWFGIP
0 1 K640‑sm VRGSNKIkFVVKkPE
0 1 K645‑sm KIkFVVKkPELVISY
2 0 Y652 kPELVISYLPPGMAs
0 1 S659‑p YLPPGMAsKINtkAL
0 1 T663‑p GMAsKINtkALQsPK
0 1 K664‑sm MAsKINtkALQsPKR
1 13 S668‑p INtkALQsPKRPRsP
1 36 S674‑p QsPKRPRsPGsNsKV
0 14 S677‑p KRPRsPGsNsKVPEI
0 15 S679‑p PRsPGsNsKVPEIEV
0 3 T687 KVPEIEVTVEGPNNN
0 4 N695 VEGPNNNNPQTsAVR
0 3 S699‑p NNNNPQTsAVRtPtQ
0 6 T703‑p PQTsAVRtPtQTNGS
0 3 T705‑p TsAVRtPtQTNGSNV
0 1 K715‑ac NGSNVPFkPRGREFs
0 1 K715‑ub NGSNVPFkPRGREFs
0 1 K715‑sm NGSNVPFkPRGREFs
0 56 S722‑p kPRGREFsFEAWNAK
0 1 K734‑sm NAKITDLkQkVENLF
0 1 K736‑sm KITDLkQkVENLFNE
0 1 K744‑sm VENLFNEkCGEALGL
0 5 K752‑ub CGEALGLkQAVKVPF
0 1 K752‑sm CGEALGLkQAVKVPF
0 1 Y770‑p ESFPEDFyVEGLPEG
2 276 S784‑p GVPFRRPstFGIPRL
0 40 T785‑p VPFRRPstFGIPRLE
0 1 K807‑sm KIKFIIKkPEMFETA
0 1 K816‑sm EMFETAIkEsTssKs
0 2 S818‑p FETAIkEsTssKsPP
0 4 S820‑p TAIkEsTssKsPPRK
0 5 S821‑p AIkEsTssKsPPRKI
0 31 S823‑p kEsTssKsPPRKINs
0 3 S830‑p sPPRKINssPNVNtt
0 7 S831‑p PPRKINssPNVNttA
0 1 T836‑p NssPNVNttAsGVED
0 1 T837‑p ssPNVNttAsGVEDL
0 1 S839‑p PNVNttAsGVEDLNI
0 1 K861‑sm DDNERLSkVEKARQL
0 2 K879‑ub VNDLFSRkFGEAIGM
0 1 K879‑sm VNDLFSRkFGEAIGM
0 1 K891‑sm IGMGFPVkVPyRkIT
0 1 Y894‑p GFPVkVPyRkITINP
0 1 K896‑sm PVkVPyRkITINPGC
0 15 Y920‑p VSFKAPSyLEISsMR
0 1 S925‑p PSyLEISsMRRILDs
0 1 S932‑p sMRRILDsAEFIKFT
0 1 S988‑p IKETDGSsQIkQEPD
0 2 K991‑sm TDGSsQIkQEPDPTW
  GTF2I iso2  
T8 MAQVAMSTLPVEDEE
S16 LPVEDEESSESRMVV
S19 EDEESSESRMVVTFL
K74 NTRKDFQKDFVKYCV
K86 YCVEEEEKAAEMHKM
K94 AAEMHKMKSTTQANR
S95 AEMHKMKSTTQANRM
S103 TTQANRMSVDAVEIE
T111 VDAVEIETLRKTVED
K130 CYGKALGKSTVVPVP
K140 VVPVPYEKMLRDQSA
K140 VVPVPYEKMLRDQSA
S146 EKMLRDQSAVVVQGL
K160 LPEGVAFKHPENYDL
T202 VGGRVMVTDADRSIL
S207 MVTDADRSILSPGGS
S210 DADRSILSPGGSCGP
S214 SILSPGGSCGPIKVK
K219 GGSCGPIKVKTEPTE
K221 SCGPIKVKTEPTEDS
S228 KTEPTEDSGISLEMA
T238 SLEMAAVTVKEESED
K240 EMAAVTVKEESEDPD
Y248‑p EESEDPDyyQyNIQG
Y249‑p ESEDPDyyQyNIQGS
Y251‑p EDPDyyQyNIQGSHH
Y277‑p VPAEDDDysPPSKRP
S278‑p PAEDDDysPPSKRPK
K285 sPPSKRPKANELPQP
A286 PPSKRPKANELPQPP
K302 PEPANAGKRKVREFN
K302 PEPANAGKRKVREFN
K312 VREFNFEKWNARITD
K312 VREFNFEKWNARITD
K331 VEELFERKYAQAIKA
K337 RKYAQAIKAKGPVTI
Y357‑p QSHVEDLyVEGLPEG
S371‑p GIPFRRPsTYGIPRL
T372 IPFRRPsTYGIPRLE
K394 RIRFVIKKHELLNST
S400 KKHELLNSTREDLQL
K409 REDLQLDKPASGVKE
K409 REDLQLDKPASGVKE
S412 LQLDKPASGVKEEWY
K415 DKPASGVKEEWYARI
K415 DKPASGVKEEWYARI
Y419 SGVKEEWYARITKLR
K435 MVDQLFCKKFAEALG
K436 VDQLFCKKFAEALGS
K436 VDQLFCKKFAEALGS
K447 ALGSTEAKAVPYQKF
K447 ALGSTEAKAVPYQKF
K453 AKAVPYQKFEAHPND
K453 AKAVPYQKFEAHPND
Y462‑p EAHPNDLyVEGLPEN
S474 PENIPFRSPSWYGIP
S476 NIPFRSPSWYGIPRL
Y478 PFRSPSWYGIPRLEK
K485 YGIPRLEKIIQVGNR
K485 YGIPRLEKIIQVGNR
K498 NRIKFVIKRPELLTH
T515 TEVTQPRTNTPVKED
T517 VTQPRTNTPVKEDWN
K520 PRTNTPVKEDWNVRI
K520 PRTNTPVKEDWNVRI
K520 PRTNTPVKEDWNVRI
S579 PEGIPFRSPTWFGIP
K599 VRGSNKIKFVVKKPE
K604 KIKFVVKKPELVISy
Y611‑p KPELVISyLPPGMAS
S618 yLPPGMASKINTKAL
T622 GMASKINTKALQsPK
K623 MASKINTKALQsPKR
S627‑p INTKALQsPKRPRsP
S633‑p QsPKRPRsPGSNSKV
S636 KRPRsPGSNSKVPEI
S638 PRsPGSNSKVPEIEV
T646 KVPEIEVTVEGPNNN
N654 VEGPNNNNPQTSAVR
S658 NNNNPQTSAVRTPTQ
T662 PQTSAVRTPTQTNGS
T664 TSAVRTPTQTNGSNV
K674 NGSNVPFKPRGREFS
K674 NGSNVPFKPRGREFS
K674 NGSNVPFKPRGREFS
S681 KPRGREFSFEAWNAK
K693 NAKITDLKQKVENLF
K695 KITDLKQKVENLFNE
K703 VENLFNEKCGEALGL
K711 CGEALGLKQAVKVPF
K711 CGEALGLKQAVKVPF
Y729‑p ESFPEDFyVEGLPEG
S743‑p GVPFRRPstFGIPRL
T744‑p VPFRRPstFGIPRLE
K766 KIKFIIKKPEMFETA
K775 EMFETAIKESTSSKS
S777 FETAIKESTSSKSPP
S779 TAIKESTSSKSPPRK
S780 AIKESTSSKSPPRKI
S782 KESTSSKSPPRKINS
S789 SPPRKINSSPNVNTT
S790 PPRKINSSPNVNTTA
T795 NSSPNVNTTASGVED
T796 SSPNVNTTASGVEDL
S798 PNVNTTASGVEDLNI
K820 DDNERLSKVEKARQL
K838 VNDLFSRKFGEAIGM
K838 VNDLFSRKFGEAIGM
K850 IGMGFPVKVPYRKIT
Y853 GFPVKVPYRKITINP
K855 PVKVPYRKITINPGC
Y879 VSFKAPSYLEISSMR
S884 PSYLEISSMRRILDS
S891 SMRRILDSAEFIKFT
S947 IKETDGSSQIKQEPD
K950 TDGSSQIKQEPDPTW
  mouse

► Hide Isoforms
 
A8 MAQVVMSALPAEDEE
S16 LPAEDEESSESRMVV
S19 EDEESSESRMVVTFL
K74 NTRKDFQKDFVKYCV
K86 YCVEEEEKAAEMHKM
K94 AAEMHKMKSTTQANR
S95 AEMHKMKSTTQANRM
S103‑p TTQANRMsVDAVEIE
T111 VDAVEIETLRKTVED
K130 CYGKALGKSTVVPVP
K140 VVPVPYEKMLRDQSA
K140 VVPVPYEKMLRDQSA
S146 EKMLRDQSAVVVQGL
K160 LPEGVAFKHPEHYDL
A202 LGGRVLAAEAERSML
S207 LAAEAERSMLsPSGS
S210‑p EAERSMLsPSGSCGP
S214 SMLsPSGSCGPIkVK
K219‑ub SGSCGPIkVKTEPTE
K221 SCGPIkVKTEPTEDS
S228 KTEPTEDSGISLEMA
T238 SLEMAAVTVKEESED
K240 EMAAVTVKEESEDPD
Y248 EESEDPDYYQYNIQG
Y249 ESEDPDYYQYNIQGP
Y251 EDPDYYQYNIQGPSE
Y317 VTIEDDDYSPPTKRL
S318 TIEDDDYSPPTKRLK
K325 SPPTKRLKsTEPPPP
S326‑p PPTKRLKsTEPPPPP
K343 PEPANAGKRKVREFN
K343 PEPANAGKRKVREFN
K353 VREFNFEKWNARITD
K353 VREFNFEKWNARITD
K372 VEELFERKYAQAIKA
K378 RKYAQAIKAKGPVTI
Y398 QSHVEDLYVEGLPEG
S412‑p GIPFRRPsTYGIPRL
T413 IPFRRPsTYGIPRLE
K435 RIRFVIKKHELLNsT
S441‑p KKHELLNsTREDLQL
K450 REDLQLDKPASGVKE
K450 REDLQLDKPASGVKE
S453 LQLDKPASGVKEEWY
K456 DKPASGVKEEWYARI
K456 DKPASGVKEEWYARI
Y460 SGVKEEWYARITKLR
K476 MVDQLFCKKFAEALG
K477 VDQLFCKKFAEALGS
K477 VDQLFCKKFAEALGS
K488 ALGSTEAKAVPYQKF
K488 ALGSTEAKAVPYQKF
K494 AKAVPYQKFEAHPND
K494 AKAVPYQKFEAHPND
Y503 EAHPNDLYVEGLPEN
S515‑p PENIPFRsPsWYGIP
S517‑p NIPFRsPsWYGIPRL
Y519 PFRsPsWYGIPRLEK
K526 YGIPRLEKIIQVGNR
K526 YGIPRLEKIIQVGNR
K539 NRIKFVIKRPELLTH
T556‑p TEVTQPRtNtPVKED
T558‑p VTQPRtNtPVKEDWN
K561 PRtNtPVKEDWNVRI
K561 PRtNtPVKEDWNVRI
K561 PRtNtPVKEDWNVRI
S620 PEGIPFRSPTWFGIP
K640 VRGSNKIKFVVKKPE
K645 KIKFVVKKPELVVSY
Y652 KPELVVSYLPPGMAS
S659 YLPPGMASKINTKAL
T663 GMASKINTKALQsPK
K664 MASKINTKALQsPKR
S668‑p INTKALQsPKRPRsP
S674‑p QsPKRPRsPGsNsKV
S677‑p KRPRsPGsNsKVPEI
S679‑p PRsPGsNsKVPEIEV
T687‑p KVPEIEVtVEGPNNS
S695‑p VEGPNNSsPQTSAVR
S699 NNSsPQTSAVRtPTQ
T703‑p PQTSAVRtPTQTNGS
T705 TSAVRtPTQTNGSNV
K715 NGSNVPFKPRGREFs
K715 NGSNVPFKPRGREFs
K715 NGSNVPFKPRGREFs
S722‑p KPRGREFsFEAWNAK
K734 NAKITDLKQKVENLF
K736 KITDLKQKVENLFNE
K744 VENLFNEKCGEALGL
K752 CGEALGLKQAVKVPF
K752 CGEALGLKQAVKVPF
Y770 ESFPEDFYVEGLPEG
S784‑p GVPFRRPstFGIPRL
T785‑p VPFRRPstFGIPRLE
K807 KIKFIIKKPEMFETA
K816 EMFETAIKESTssKs
S818 FETAIKESTssKsPP
S820‑p TAIKESTssKsPPRK
S821‑p AIKESTssKsPPRKI
S823‑p KESTssKsPPRKINs
S830‑p sPPRKINssPNVNTT
S831‑p PPRKINssPNVNTTA
T836 NssPNVNTTAsGVED
T837 ssPNVNTTAsGVEDL
S839‑p PNVNTTAsGVEDLNI
K861 DDNERLSKVEKARQL
K879‑ub VNDLFSRkFGEAIGM
K879 VNDLFSRKFGEAIGM
K891 IGMGFPVKVPYRKIT
Y894 GFPVKVPYRKITINP
K896 PVKVPYRKITINPGC
Y920‑p VSFKAPSyLEISSMR
S925 PSyLEISSMRRILDS
S932 SMRRILDSAEFIKFT
S988 IKETDGSSQIKQEPD
K991 TDGSSQIKQEPDPTW
  GTF2I iso8  
A8 MAQVVMSALPAEDEE
S16 LPAEDEESSESRMVV
S19 EDEESSESRMVVTFL
K74 NTRKDFQKDFVKYCV
K86 YCVEEEEKAAEMHKM
K94 AAEMHKMKSTTQANR
S95 AEMHKMKSTTQANRM
S103 TTQANRMSVDAVEIE
T111 VDAVEIETLRKTVED
K130 CYGKALGKSTVVPVP
K140 VVPVPYEKMLRDQSA
K140 VVPVPYEKMLRDQSA
S146 EKMLRDQSAVVVQGL
K160 LPEGVAFKHPEHYDL
A202 LGGRVLAAEAERSML
S207 LAAEAERSMLSPSGS
S210 EAERSMLSPSGSCGP
S214 SMLSPSGSCGPIKVK
K219 SGSCGPIKVKTEPTE
K221 SCGPIKVKTEPTEDS
S228 KTEPTEDSGISLEMA
T238 SLEMAAVTVKEESED
K240 EMAAVTVKEESEDPD
Y248 EESEDPDYYQYNIQG
Y249 ESEDPDYYQYNIQGS
Y251 EDPDYYQYNIQGSHH
Y277 VPAEDDDYSPPTKRL
S278 PAEDDDYSPPTKRLK
K285 SPPTKRLKSTEPPPP
S286 PPTKRLKSTEPPPPP
K303 PEPANAGKRKVREFN
K303 PEPANAGKRKVREFN
K313 VREFNFEKWNARITD
K313 VREFNFEKWNARITD
K332 VEELFERKYAQAIKA
K338 RKYAQAIKAKGPVTI
Y358 QSHVEDLYVEGLPEG
S372‑p GIPFRRPsTYGIPRL
T373 IPFRRPsTYGIPRLE
K395 RIRFVIKKHELLNST
S401 KKHELLNSTREDLQL
K410 REDLQLDKPASGVKE
K410 REDLQLDKPASGVKE
S413 LQLDKPASGVKEEWY
K416 DKPASGVKEEWYARI
K416 DKPASGVKEEWYARI
Y420 SGVKEEWYARITKLR
K436 MVDQLFCKKFAEALG
K437 VDQLFCKKFAEALGS
K437 VDQLFCKKFAEALGS
K448 ALGSTEAKAVPYQKF
K448 ALGSTEAKAVPYQKF
K454 AKAVPYQKFEAHPND
K454 AKAVPYQKFEAHPND
Y463 EAHPNDLYVEGLPEN
S475 PENIPFRSPSWYGIP
S477 NIPFRSPSWYGIPRL
Y479 PFRSPSWYGIPRLEK
K486 YGIPRLEKIIQVGNR
K486 YGIPRLEKIIQVGNR
K499 NRIKFVIKRPELLTH
T516 TEVTQPRTNTPVKED
T518 VTQPRTNTPVKEDWN
K521 PRTNTPVKEDWNVRI
K521 PRTNTPVKEDWNVRI
K521 PRTNTPVKEDWNVRI
S580 PEGIPFRSPTWFGIP
K600 VRGSNKIKFVVKKPE
K605 KIKFVVKKPELVVSY
Y612 KPELVVSYLPPGMAS
S619 YLPPGMASKINTKAL
T623 GMASKINTKALQSPK
K624 MASKINTKALQSPKR
S628 INTKALQSPKRPRSP
S634 QSPKRPRSPGSNSKV
S637 KRPRSPGSNSKVPEI
S639 PRSPGSNSKVPEIEV
T647 KVPEIEVTVEGPNNS
S655 VEGPNNSSPQTSAVR
S659 NNSSPQTSAVRTPTQ
T663 PQTSAVRTPTQTNGS
T665 TSAVRTPTQTNGSNV
K675 NGSNVPFKPRGREFS
K675 NGSNVPFKPRGREFS
K675 NGSNVPFKPRGREFS
S682 KPRGREFSFEAWNAK
K694 NAKITDLKQKVENLF
K696 KITDLKQKVENLFNE
K704 VENLFNEKCGEALGL
K712 CGEALGLKQAVKVPF
K712 CGEALGLKQAVKVPF
Y730 ESFPEDFYVEGLPEG
S744‑p GVPFRRPsTFGIPRL
T745 VPFRRPsTFGIPRLE
K767 KIKFIIKKPEMFETA
K776 EMFETAIKESTSSKs
S778 FETAIKESTSSKsPP
S780 TAIKESTSSKsPPIF
S781 AIKESTSSKsPPIFL
S783‑p KESTSSKsPPIFLSG
S794 FLSGKINSSPNVNTT
S795 LSGKINSSPNVNTTA
T800 NSSPNVNTTASGVED
T801 SSPNVNTTASGVEDL
S803 PNVNTTASGVEDLNI
K825 DDNERLSKVEKARQL
K843 VNDLFSRKFGEAIGM
K843 VNDLFSRKFGEAIGM
K855 IGMGFPVKVPYRKIT
Y858 GFPVKVPYRKITINP
K860 PVKVPYRKITINPGC
Y884 VSFKAPSYLEISSMR
S889 PSYLEISSMRRILDS
S896 SMRRILDSAEFIKFT
S952 IKETDGSSQIKQEPD
K955 TDGSSQIKQEPDPTW
  rat

► Hide Isoforms
 
A8 MAQVAMSALPAEDEE
S16 LPAEDEESSESRMVV
S19 EDEESSESRMVVTFL
K74 NTRKDFQKDFVKYCV
K86 YCVEEEEKAAEMHKM
K94 AAEMHKMKCTTQANR
C95 AEMHKMKCTTQANRM
S103 TTQANRMSVDAVEIE
T111 VDAVEIETLRKTVED
K130 CYGKALGKSTVVPVP
K140 VVPVPYEKMLRDQSA
K140 VVPVPYEKMLRDQSA
S146 EKMLRDQSAVAVQGL
K160 LPEGVAFKHPEHYDL
A202 LGGRVMAADADRPML
P207 MAADADRPMLsPGGS
S210‑p DADRPMLsPGGSCGP
S214 PMLsPGGSCGPIKVK
K219 GGSCGPIKVKTEPTE
K221 SCGPIKVKTEPTEDS
S228 KTEPTEDSGISLEMA
T238 SLEMAAVTVKEESED
K240 EMAAVTVKEESEDPD
Y248 EESEDPDYYQYNIQG
Y249 ESEDPDYYQYNIQGS
Y251 EDPDYYQYNIQGSHH
Y298 VTIEDDDYSPPTKRP
S299 TIEDDDYSPPTKRPK
K306 SPPTKRPKSSEPPPP
S307 PPTKRPKSSEPPPPP
K324 PEPTNAGKRKVREFN
K324 PEPTNAGKRKVREFN
K334 VREFNFEKWNARITD
K334 VREFNFEKWNARITD
K353 VEELFERKYAQAIKA
K359 RKYAQAIKAKGPVTI
Y379 QSHVEDLYVEGLPEG
S393‑p GIPFRRPsTYGIPRL
T394 IPFRRPsTYGIPRLE
K416 RIRFVIKKHELLNST
S422 KKHELLNSTREDLQL
K431‑ac REDLQLDkPASGVKE
K431 REDLQLDKPASGVKE
S434 LQLDkPASGVKEEWY
K437 DkPASGVKEEWYARI
K437 DkPASGVKEEWYARI
Y441 SGVKEEWYARITKLR
K457 MVDQLFCKKFAEALG
K458 VDQLFCKKFAEALGS
K458 VDQLFCKKFAEALGS
K469 ALGSTEAKAVPYQKF
K469 ALGSTEAKAVPYQKF
K475 AKAVPYQKFEAYPND
K475 AKAVPYQKFEAYPND
Y484 EAYPNDLYVEGLPEN
S496 PENIPFRSPSWYGIP
S498 NIPFRSPSWYGIPRL
Y500 PFRSPSWYGIPRLEK
K507 YGIPRLEKIIQVGNR
K507 YGIPRLEKIIQVGNR
K520 NRIKFVIKRPELLTH
T537 TEVTQPRTNTPVKED
T539 VTQPRTNTPVKEDWN
K542 PRTNTPVKEDWNVRI
K542 PRTNTPVKEDWNVRI
K542 PRTNTPVKEDWNVRI
S601 PEGIPFRSPTWFGIP
K621 VRGSNKIKFVVKKPE
K626 KIKFVVKKPELVVSY
Y633 KPELVVSYLPPGMAS
S640 YLPPGMASKINTKAL
T644 GMASKINTKALQSPK
K645 MASKINTKALQSPKR
S649 INTKALQSPKRPRSP
S655 QSPKRPRSPGSNSKV
S658 KRPRSPGSNSKVPEI
S660 PRSPGSNSKVPEIEV
T668 KVPEIEVTVEGPNNN
S676 VEGPNNNSPQTSTVR
S680 NNNSPQTSTVRTPTQ
T684 PQTSTVRTPTQTNGS
T686 TSTVRTPTQTNGSNV
K696 NGSNVPFKPRGREFS
K696 NGSNVPFKPRGREFS
K696 NGSNVPFKPRGREFS
S703 KPRGREFSFEAWNAK
K715 NAKITDLKQKVENLF
K717 KITDLKQKVENLFNE
K725 VENLFNEKCGEALGL
K733 CGEALGLKQAVKVPF
K733 CGEALGLKQAVKVPF
Y751 ESFPEDFYVEGLPEG
S765‑p GVPFRRPsTFGIPRL
T766 VPFRRPsTFGIPRLE
K788 KIKFIIKKPEMFETA
K797 EMFETAIKESTSSKS
S799 FETAIKESTSSKSPP
S801 TAIKESTSSKSPPRK
S802 AIKESTSSKSPPRKT
S804 KESTSSKSPPRKTNS
S811 SPPRKTNSSPSVNTT
S812 PPRKTNSSPSVNTTA
T817 NSSPSVNTTASGVED
T818 SSPSVNTTASGVEDL
S820 PSVNTTASGVEDLNI
K842 DDNERLSKVEKARQL
K860 VNDLFSRKFGEAIGM
K860 VNDLFSRKFGEAIGM
K872 IGMGFPVKVPYRKIT
Y875 GFPVKVPYRKITINP
K877 PVKVPYRKITINPGC
Y901 VSFKAPSYLEISSMR
S906 PSYLEISSMRRILDS
S913 SMRRILDSAEFIKFT
S969 IKETDGSSQIKQEPD
K972 TDGSSQIKQEPDPTW
  GTF2I iso2  
A8 MAQVAMSALPAEDEE
S16 LPAEDEESSESRMVV
S19 EDEESSESRMVVTFL
K74 NTRKDFQKDFVKYCV
K86 YCVEEEEKAAEMHKM
K94 AAEMHKMKCTTQANR
C95 AEMHKMKCTTQANRM
S103 TTQANRMSVDAVEIE
T111 VDAVEIETLRKTVED
K130 CYGKALGKSTVVPVP
K140 VVPVPYEKMLRDQSA
K140 VVPVPYEKMLRDQSA
S146 EKMLRDQSAVAVQGL
K160 LPEGVAFKHPEHYDL
A202 LGGRVMAADADRPML
P207 MAADADRPMLSPGGS
S210 DADRPMLSPGGSCGP
S214 PMLSPGGSCGPIKVK
K219 GGSCGPIKVKTEPTE
K221 SCGPIKVKTEPTEDs
S228‑p KTEPTEDsDDDYSPP
- gap
- gap
- gap
- gap
- gap
Y232 TEDsDDDYSPPTKRP
S233 EDsDDDYSPPTKRPK
K240 SPPTKRPKSSEPPPP
S241 PPTKRPKSSEPPPPP
K258 PEPTNAGKRKVREFN
K258 PEPTNAGKRKVREFN
K268 VREFNFEKWNARITD
K268 VREFNFEKWNARITD
K287 VEELFERKYAQAIKA
K293 RKYAQAIKAKGPVTI
Y313 QSHVEDLYVEGLPEG
S327 GIPFRRPSTYGIPRL
T328 IPFRRPSTYGIPRLE
K350 RIRFVIKKHELLNST
S356 KKHELLNSTREDLQL
K365 REDLQLDKPASGVKE
K365 REDLQLDKPASGVKE
S368 LQLDKPASGVKEEWY
K371 DKPASGVKEEWYARI
K371 DKPASGVKEEWYARI
Y375 SGVKEEWYARITKLR
K391 MVDQLFCKKFAEALG
K392 VDQLFCKKFAEALGS
K392 VDQLFCKKFAEALGS
K403 ALGSTEAKAVPYQKF
K403 ALGSTEAKAVPYQKF
K409 AKAVPYQKFEAYPND
K409 AKAVPYQKFEAYPND
Y418 EAYPNDLYVEGLPEN
S430 PENIPFRSPSWYGIP
S432 NIPFRSPSWYGIPRL
Y434 PFRSPSWYGIPRLEK
K441 YGIPRLEKIIQVGNR
K441 YGIPRLEKIIQVGNR
K454 NRIKFVIKRPELLTH
T471 TEVTQPRTNTPVKED
T473 VTQPRTNTPVKEDWN
K476 PRTNTPVKEDWNVRI
K476 PRTNTPVKEDWNVRI
K476 PRTNTPVKEDWNVRI
S535 PEGIPFRSPTWFGIP
K555 VRGSNKIKFVVKKPE
K560 KIKFVVKKPELVVSY
Y567 KPELVVSYLPPGMAS
S574 YLPPGMASKINTKAL
T578 GMASKINTKALQSPK
K579 MASKINTKALQSPKR
S583 INTKALQSPKRPRSP
S589 QSPKRPRSPGSNSKV
S592 KRPRSPGSNSKVPEI
S594 PRSPGSNSKVPEIEV
T602 KVPEIEVTVEGPNNN
S610 VEGPNNNSPQTSTVR
S614 NNNSPQTSTVRTPTQ
T618 PQTSTVRTPTQTNGS
T620 TSTVRTPTQTNGSNV
K630 NGSNVPFKPRGREFS
K630 NGSNVPFKPRGREFS
K630 NGSNVPFKPRGREFS
S637 KPRGREFSFEAWNAK
K649 NAKITDLKQKVENLF
K651 KITDLKQKVENLFNE
K659 VENLFNEKCGEALGL
K667 CGEALGLKQAVKVPF
K667 CGEALGLKQAVKVPF
Y685 ESFPEDFYVEGLPEG
S699 GVPFRRPSTFGIPRL
T700 VPFRRPSTFGIPRLE
K722 KIKFIIKKPEMFETA
K731 EMFETAIKESTSSKS
S733 FETAIKESTSSKSPP
S735 TAIKESTSSKSPPRK
S736 AIKESTSSKSPPRKT
S738 KESTSSKSPPRKTNS
S745 SPPRKTNSSPSVNTT
S746 PPRKTNSSPSVNTTA
T751 NSSPSVNTTASGVED
T752 SSPSVNTTASGVEDL
S754 PSVNTTASGVEDLNI
K776 DDNERLSKVEKARQL
K794 VNDLFSRKFGEAIGM
K794 VNDLFSRKFGEAIGM
K806 IGMGFPVKVPYRKIT
Y809 GFPVKVPYRKITINP
K811 PVKVPYRKITINPGC
Y835 VSFKAPSYLEISSMR
S840 PSYLEISSMRRILDS
S847 SMRRILDSAEFIKFT
S903 IKETDGSSQIKQEPD
K906 TDGSSQIKQEPDPTW
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