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Protein Page:
AFAP1L2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
AFAP1L2 May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Activator
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein tyrosine kinase activator activity; SH2 domain binding; SH3 domain binding
Biological Process: inflammatory response; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of transcription, DNA-dependent; regulation of interleukin-6 production; regulation of mitotic cell cycle
Reference #:  Q8N4X5 (UniProtKB)
Alt. Names/Synonyms: actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AF1L2; AFAP1-like protein 2; AFAP1L2; CTB-1144G6.4; FLJ14564; KIAA1914; XB130
Gene Symbols: AFAP1L2
Molecular weight: 91,300 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

AFAP1L2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
molecular association, regulation: Y54‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S50‑p LYTKSSSsDEEyIyM
1 175 Y54‑p SSSsDEEyIyMNKVt
0 108 Y56‑p SsDEEyIyMNKVtIN
0 2 T61‑p yIyMNKVtINKQQNA
0 2 S70 NKQQNAESQGKAPEE
0 1 A113 IPERKQLAIPKTEsP
0 6 S119‑p LAIPKTEsPEGYyEE
0 17 Y124‑p TEsPEGYyEEAEPYD
0 1 S142 NEDGEAVSSSYESYD
0 1 S147 AVSSSYESYDEEDGS
0 1 Y161‑p SKGKSAPyQWPsPEA
0 1 S165‑p SAPyQWPsPEAGIEL
0 2 S213‑p YKSSKDHsPQLDVNL
0 1 T284‑p ASEGNQYtPDAQRFN
0 13 Y301‑p KPDIAEKyLsASEyG
0 1 S303‑p DIAEKyLsASEyGSS
0 3 Y307‑p KyLsASEyGSSVDGH
0 1 S334‑p CSAGLKLsNLMNLGR
0 30 S344‑p MNLGRKKstsLEPVE
0 8 T345‑p NLGRKKstsLEPVER
0 8 S346‑p LGRKKstsLEPVERS
0 1 S358‑p ERSLETSsyLNVLVN
0 26 Y359‑p RSLETSsyLNVLVNS
0 317 Y383‑p RDNHLHFyQDRNRSK
0 1 S397‑p KVAQQPLsLVGCEVV
0 94 S408‑p CEVVPDPsPDHLysF
0 1364 Y413‑p DPsPDHLysFRILHK
0 130 S414‑p PsPDHLysFRILHKG
0 1 S431‑p LAKLEAKssEEMGHW
0 1 S432‑p AKLEAKssEEMGHWL
0 2 T456‑p KTDPEEFtyDyVDAD
0 4 Y457‑p TDPEEFtyDyVDADR
0 57 Y459‑p PEEFtyDyVDADRVs
0 1 S466‑p yVDADRVsCIVSAAK
0 15 S484‑p LLMQRKFsEPNTyID
0 1 T488 RKFsEPNTyIDGLPS
0 2 Y489‑p KFsEPNTyIDGLPSQ
0 20 Y537‑p ERESDRVyLDLtPVK
0 5 T541‑p DRVyLDLtPVKSFLH
0 1 T635‑p CPDAVVAtPPGAsPP
0 4 S640‑p VAtPPGAsPPVKDRL
0 1 S651‑p KDRLRVTsAEIKLGK
0 1 Y668‑p TEAEVKRytEEKERL
0 1 T669‑p EAEVKRytEEKERLE
0 1 K697‑ac RKEKRELkETLLKCT
0 3 S767‑p TTHLENVsPRPKAVt
0 1 T774‑p sPRPKAVtPASAPDC
0 1 T788‑p CTPVNSAtTLKNRPL
0 5 S796‑p TLKNRPLsVVVTGKG
  AFAP1L2 iso2  
S50 LYTKSSSSDEEYIYM
Y54 SSSSDEEYIYMNKVT
Y56 SSDEEYIYMNKVTIN
T61 YIYMNKVTINKQQNA
S70 NKQQNAESQGKAPEE
A113 IPERKQLAIPKTESP
S119 LAIPKTESPEGYYEE
Y124 TESPEGYYEEAEPYD
S142 NEDGEAVSSSYESYD
S147 AVSSSYESYDEEDGS
Y161 SKGKSAPYQWPSPEA
S165 SAPYQWPSPEAGIEL
S213 YKSSKDHSPQLDVNL
T284 ASEGNQYTPDAQRFN
Y301 KPDIAEKYLSASEYG
S303 DIAEKYLSASEYGSS
Y307 KYLSASEYGSSVDGH
S334 CSAGLKLSNLMNLGR
S344 MNLGRKKSTSLEPVE
T345 NLGRKKSTSLEPVER
S346 LGRKKSTSLEPVERS
S358 ERSLETSSYLNVLVN
Y359 RSLETSSYLNVLVNS
Y383 RDNHLHFYQDRNRSK
S397 KVAQQPLSLVGCEVV
S408 CEVVPDPSPDHLYSF
Y413 DPSPDHLYSFRILHK
S414 PSPDHLYSFRILHKG
S431 LAKLEAKSSEEMGHW
S432 AKLEAKSSEEMGHWL
T456 KTDPEEFTYDYVDAD
Y457 TDPEEFTYDYVDADR
Y459 PEEFTYDYVDADRVS
S466 YVDADRVSCIVSAAK
S484 LLMQRKFSEPNTYID
T488 RKFSEPNTYIDGLPS
Y489 KFSEPNTYIDGLPSQ
Y537 ERESDRVYLDLTPVK
T541 DRVYLDLTPVKSFLH
T635 CPDAVVATPPGASPP
S640 VATPPGASPPVKDRL
S651 KDRLRVTSAEIKLGK
Y668 TEAEVKRYTEEKERL
T669 EAEVKRYTEEKERLE
K697 RKEKRELKETLLKCT
- gap
T770 LENPKAVTPASAPDC
T784 CTPVNSATTLKNRPL
S792 TLKNRPLSVVVTGKG
  mouse

 
S50 LYTKSSSSDEEyIyM
Y54‑p SSSSDEEyIyMNKVS
Y56‑p SSDEEyIyMNKVSVN
S61 yIyMNKVSVNGEQNS
S70 NGEQNSASPDKVPEE
T113‑p IPERKQPtVPKIEsP
S119‑p PtVPKIEsPEGYyEE
Y124‑p IEsPEGYyEEAEPFD
S142‑p NEDGEAVsSSYEsYD
S147‑p AVsSSYEsYDEDENS
Y161 SKGKAAPYQWPSPEA
S165 AAPYQWPSPEASIEL
S213‑p YKSSKDHsPQLDVNL
T284 ASEGNQYTPDAQRLN
Y301 KPDIAEKYLSAAEYG
S303 DIAEKYLSAAEYGIT
Y307 KYLSAAEYGITINGH
S334 CSAGLKLSNLMNLGR
S344‑p MNLGRKKsTSLEPPE
T345 NLGRKKsTSLEPPER
S346 LGRKKsTSLEPPERS
S358 ERSLETSSYLNVLVN
Y359 RSLETSSYLNVLVNS
Y383‑p RDSHLHFyQDRNRSK
S397 KVAQQPLSLVGCDVL
S408‑p CDVLPDPsPDHLysF
Y413‑p DPsPDHLysFRILHN
S414‑p PsPDHLysFRILHNG
S431 LAKLEAKSSEEMGHW
S432 AKLEAKSSEEMGHWL
T456 KTDPEELTyDyVDAE
Y457‑p TDPEELTyDyVDAER
Y459‑p PEELTyDyVDAERVS
S466 yVDAERVSCIVSAAK
S484‑p LLMQRKFsEPNtYID
T488‑p RKFsEPNtYIDGLPS
Y489 KFsEPNtYIDGLPSR
Y537‑p GSEPDRVyLDLTPVK
T541 DRVyLDLTPVKSFLH
A640 CPDTMASAPIAAsPP
S645‑p ASAPIAAsPPVKEKL
S656 KEKLRVTSAEIKLGK
Y673 TEAEVKRYTEEKERL
T674 EAEVKRYTEEKERLE
K702 RREKRELKETLLRCT
S772‑p TTHLDNMsPRPQPKA
T781 RPQPKAATPNPPPDS
S795 STPVNSASVLKNRPL
S803‑p VLKNRPLsVMVTGKG
  rat

 
S50 LYTKSSSSDEEYIYM
Y54 SSSSDEEYIYMNKVA
Y56 SSDEEYIYMNKVAVN
A61 YIYMNKVAVNKEQNP
S70‑p NKEQNPAsPDKVPEE
T114 IPERKQPTIPKIESP
S120 PTIPKIESPEGYYEE
Y125 IESPEGYYEEAEPFD
S143 NEDGEAVSSSYESYD
S148 AVSSSYESYDEEESS
Y162 SKGKTAPYQWPSPEA
S166 TAPYQWPSPEASIEL
S214 YKSSKDHSPQLDVNL
T285 ASEGNQYTPDAQRLN
Y302 KPDIAEKYMSASEYG
S304 DIAEKYMSASEYGIT
Y308 KYMSASEYGITTDGH
S335 CSAGLKLSNLMNLGR
S345‑p MNLGRKKsTSLEPPD
T346 NLGRKKsTSLEPPDR
S347 LGRKKsTSLEPPDRS
S359 DRSLETSSYLNVLVN
Y360 RSLETSSYLNVLVNS
Y384 RDSHLHFYQDRNRGK
S398 KMAQQPLSLVGCDVL
S409 CDVLPDPSPDHLySF
Y414‑p DPSPDHLySFRILHN
S415 PSPDHLySFRILHNG
S432 LAKLEAKSSEEMGHW
S433 AKLEAKSSEEMGHWL
T457 KTDPEELTYDYVDAE
Y458 TDPEELTYDYVDAER
Y460 PEELTYDYVDAERVS
S467 YVDAERVSCIVSAAK
S485‑p LLMQRKFsEPNTYID
T489 RKFsEPNTYIDGLPS
Y490 KFsEPNTYIDGLPSR
Y544 GSDLDRVYLDLtPVK
T548‑p DRVYLDLtPVKSFLH
V647 CPDTMASVPISASPP
S652 ASVPISASPPVKDKL
S663 KDKLRVTSAEIKLGK
Y680 TEAEVKRYTEEKRRL
T681 EAEVKRYTEEKRRLE
K709 RREKRELKETLLRCT
S779 TTHLDNMSPRPQPKA
T788 RPQPKAATPTSTPDS
S802 STPVNSASVLKNRPL
S810 VLKNRPLSVMVTGKG
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