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Protein Page:
NFL (human)

Overview
NFL one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F). Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 8p21
Cellular Component: axon; cytoplasm; cytosol; neurofilament; TSC1-TSC2 complex
Molecular Function: identical protein binding; protein binding; protein binding, bridging; protein C-terminus binding; Ras guanyl-nucleotide exchange factor activity; structural constituent of cytoskeleton
Biological Process: anterograde axon cargo transport; axon transport of mitochondrion; intermediate filament organization; MAPKKK cascade; neurofilament bundle assembly; retrograde axon cargo transport
Disease: Charcot-marie-tooth Disease, Axonal, Type 2e; Charcot-marie-tooth Disease, Demyelinating, Type 1f
Reference #:  P07196 (UniProtKB)
Alt. Names/Synonyms: 68 kDa neurofilament protein; CMT1F; CMT2E; FLJ53642; light molecular weight neurofilament protein; NEFL; Neurofilament light polypeptide; neurofilament protein, light chain; neurofilament subunit NF-L; Neurofilament triplet L protein; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament-light; NF-L; NF68; NFL
Gene Symbols: NEFL
Molecular weight: 61,517 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFL

Protein Structure Not Found.


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