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Protein Page:
MMP9 (human)

Overview
MMP9 May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. Produced by normal alveolar macrophages and granulocytes. Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
Protein type: Protease; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; EC 3.4.24.35
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: collagen binding; endopeptidase activity; identical protein binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; serine-type endopeptidase activity; zinc ion binding
Biological Process: collagen catabolic process; embryo implantation; ephrin receptor signaling pathway; extracellular matrix disassembly; leukocyte migration; macrophage differentiation; negative regulation of apoptosis; ossification; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; positive regulation of protein amino acid phosphorylation; proteolysis; skeletal development
Disease: Metaphyseal Anadysplasia 2
Reference #:  P14780 (UniProtKB)
Alt. Names/Synonyms: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; CLG4B; Gelatinase B; GELB; macrophage gelatinase; MANDP2; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix metalloproteinase-9; MMP-9; MMP9; type V collagenase
Gene Symbols: MMP9
Molecular weight: 78,458 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MMP9

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T37‑p LFPGDLRtNLTDRQL
0 1 Y241‑p FIFEGRSySACTTDG
0 1 S628‑p RGKMLLFsGRRLWRF
  mouse

 
T37 VFPKDLKTSNLTDTQ
Y241 FTFEGRSYSACTTDG
S646 LGKALLFSKGRVWRF
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