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Protein Page:
CASP3 (mouse)

Overview
CASP3 Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease
Cellular Component: cytoplasm; cytosol; lipid raft; nucleus
Molecular Function: aspartic-type endopeptidase activity; cyclin-dependent protein kinase inhibitor activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; death receptor binding; peptidase activity; phospholipase A2 activator activity; protease binding; protein complex binding
Biological Process: apoptosis; B cell homeostasis; cell fate commitment; erythrocyte differentiation; heart development; keratinocyte differentiation; learning and/or memory; negative regulation of activated T cell proliferation; negative regulation of apoptosis; negative regulation of B cell proliferation; negative regulation of cell cycle; negative regulation of cyclin-dependent protein kinase activity; nerve growth factor receptor signaling pathway; neuron apoptosis; neuron differentiation; positive regulation of apoptosis; positive regulation of neuron apoptosis; protein processing; proteolysis; response to DNA damage stimulus; response to glucose stimulus; response to hydrogen peroxide; response to organic substance; response to UV; response to wounding; sensory perception of sound; T cell homeostasis
Reference #:  P70677 (UniProtKB)
Alt. Names/Synonyms: A830040C14Rik; Apopain; CASP-3; Casp3; caspase 3; caspase 3, apoptosis related cysteine protease; Caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; CPP-32; Cpp32; Cysteine protease CPP32; LICE; mldy; Protein Yama; SCA-1; SREBP cleavage activity 1; Yama
Gene Symbols: Casp3
Molecular weight: 31,475 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CASP3

Protein Structure Not Found.
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