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Protein Page:
Nik (human)

Nik a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; cytosol
Molecular Function: kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell costimulation; tumor necrosis factor-mediated signaling pathway
Reference #:  Q99558 (UniProtKB)
Alt. Names/Synonyms: FTDCR1B; HS; HsNIK; M3K14; MAP3K14; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; NIK; serine/threonine protein-kinase; Serine/threonine-protein kinase NIK
Gene Symbols: MAP3K14
Molecular weight: 104,042 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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