Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: apical plasma membrane; basolateral plasma membrane; catenin complex; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasm; fascia adherens; focal adhesion; integral to membrane; intercellular junction; lamellipodium; plasma membrane; synapse
Molecular Function: alpha-catenin binding; beta-catenin binding; calcium ion binding; gamma-catenin binding; nitric-oxide synthase binding; protein binding; protein complex binding; protein kinase binding; protein phosphatase binding
Biological Process: blood vessel morphogenesis; brain morphogenesis; calcium-dependent cell-cell adhesion; cell adhesion; cell migration; cerebral cortex development; glial cell differentiation; heterophilic cell adhesion; homeostasis of number of cells; homophilic cell adhesion; positive regulation of MAPKKK cascade; positive regulation of muscle cell differentiation; protein heterooligomerization; radial glial cell differentiation; regulation of axonogenesis; regulation of myelination; regulation of Rho protein signal transduction; striated muscle cell differentiation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.