Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; GAPs, Ras; GAPs
Cellular Component: actin cytoskeleton; actin filament; axon; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; growth cone; lateral plasma membrane; microtubule; microtubule cytoskeleton; midbody; neuron projection; plasma membrane; protein complex; ruffle
Molecular Function: calcium ion binding; calmodulin binding; GTPase activator activity; GTPase inhibitor activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein complex binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activator activity; Rac GTPase binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; negative regulation of dephosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of protein kinase activity; regulation of cytokine production; signal transduction; small GTPase mediated signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.