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Protein Page:
MBP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MBP The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Homodimer. Isoform 3 exists as a homodimer. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Belongs to the myelin basic protein family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: cell soma; compact myelin; internode region of axon; nucleus; plasma membrane
Molecular Function: protease binding; protein binding; structural constituent of myelin sheath
Biological Process: aging; axon ensheathment; central nervous system development; immune response; myelination; negative regulation of axonogenesis; response to mercury ion; response to progesterone stimulus; response to toxin; substantia nigra development; synaptic transmission
Reference #:  P02686 (UniProtKB)
Gene Symbols: MBP
Molecular weight: 33,117 Da
Basal Isoelectric point: 9.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MBP

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 A5 ___MGNHAGKRELNA
0 1 S16‑p ELNAEKAsTNsETNR
0 1 S19‑p AEKAsTNsETNRGEs
0 2 S26‑p sETNRGEsEKKRNLG
0 1 N31 GEsEKKRNLGELsRt
0 10 S36‑p KRNLGELsRttsEDN
0 1 T38‑p NLGELsRttsEDNEV
0 2 T39‑p LGELsRttsEDNEVF
0 8 S40‑p GELsRttsEDNEVFG
0 3 N43 sRttsEDNEVFGEAD
0 1 S87‑p AHPADPGsRPHLIRL
0 14 S96‑p PHLIRLFsRDAPGRE
0 2 T106‑p APGREDNtFKDRPSE
0 1 S112 NtFKDRPSEsDELQT
0 2 S114‑p FKDRPSEsDELQTIQ
0 1 K138 LDVMASQKRPsQRHG
3 3 S141‑p MASQKRPsQRHGsKy
1 9 S146‑p RPsQRHGsKyLATAs
0 1 K147 PsQRHGsKyLATAst
0 2 K147 PsQRHGsKyLATAst
0 1 K147 PsQRHGsKyLATAst
0 7 Y148‑p sQRHGsKyLATAstM
0 6 T151 HGsKyLATAstMDHA
2 7 S153‑p sKyLATAstMDHARH
1 6 T154‑p KyLATAstMDHARHG
3 9 T169‑p FLPRHRDtGILDSIG
0 6 S174 RDtGILDSIGRFFGG
0 1 S174 RDtGILDSIGRFFGG
0 1 R177 GILDSIGRFFGGDRG
0 3 G180 DSIGRFFGGDRGAPK
1 0 G181 SIGRFFGGDRGAPKR
0 2 R183 GRFFGGDRGAPKRGS
2 4 S190 RGAPKRGSGKDSHHP
0 1 - gap
0 1 - gap
0 1 - gap
0 7 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 K192 APKRGSGKDSHHPAR
0 1 S194 KRGSGKDSHHPARTA
0 1 A198 GKDSHHPARTAHyGs
1 2 T200 DSHHPARTAHyGsLP
2 2 A201 SHHPARTAHyGsLPQ
0 105 Y203‑p HPARTAHyGsLPQKS
0 25 S205‑p ARTAHyGsLPQKSHG
0 1 S205 ARTAHyGSLPQKSHG
0 2 K209 HyGsLPQKSHGRTQD
0 21 K209 HyGsLPQKSHGRTQD
1 26 S210 yGsLPQKSHGRTQDE
0 5 T214 PQKSHGRTQDENPVV
0 1 T214 PQKSHGRTQDENPVV
0 3 K225 NPVVHFFKNIVTPRt
0 20 K225 NPVVHFFKNIVTPRt
5 2 T229 HFFKNIVTPRtPPPS
15 19 T232‑p KNIVTPRtPPPSQGK
1 1 K239 tPPPSQGKGrGLSLS
3 3 R241‑m1 PPSQGKGrGLSLSRF
2 2 R241‑m2 PPSQGKGrGLSLSRF
2 1 S244 QGKGrGLSLSRFsWG
4 11 S249‑p GLSLSRFsWGAEGQR
0 3 R256 sWGAEGQRPGFGyGG
0 9 R256 sWGAEGQRPGFGyGG
0 25 Y261‑p GQRPGFGyGGRAsDY
0 2 R264 PGFGyGGRAsDYKSA
1 1 S266‑p FGyGGRAsDYKSAHK
0 1 K276 KSAHKGFKGVDAQGt
0 4 K276 KSAHKGFKGVDAQGt
1 0 - gap
0 66 - gap
1 3 T283‑p KGVDAQGtLsKIFKL
2 3 S285‑p VDAQGtLsKIFKLGG
0 1 K286 DAQGtLsKIFKLGGR
0 1 K289 GtLsKIFKLGGRDSR
2 3 S295 FKLGGRDSRSGSPMA
1 0 - gap
0 2 S297 LGGRDSRSGSPMARR
5 4 S299 GRDSRSGSPMARR__
  MBP iso2  
A5 ___MGNHAGKRELNA
S16 ELNAEKASTNSETNR
S19 AEKASTNSETNRGES
S26 SETNRGESEKKRNLG
N31 GESEKKRNLGELSRT
S36 KRNLGELSRTTSEDN
T38 NLGELSRTTSEDNEV
T39 LGELSRTTSEDNEVF
S40 GELSRTTSEDNEVFG
N43 SRTTSEDNEVFGEAD
S87 AHPADPGSRPHLIRL
S96 PHLIRLFSRDAPGRE
T106 APGREDNTFKDRPSE
S112 NTFKDRPSESDELQT
S114 FKDRPSESDELQTIQ
K138 LDVMASQKRPSQRHG
S141 MASQKRPSQRHGSKY
S146 RPSQRHGSKYLATAS
K147 PSQRHGSKYLATAST
K147 PSQRHGSKYLATAST
K147 PSQRHGSKYLATAST
Y148 SQRHGSKYLATASTM
T151 HGSKYLATASTMDHA
S153 SKYLATASTMDHARH
T154 KYLATASTMDHARHG
T169 FLPRHRDTGILDSIG
S174 RDTGILDSIGRFFGG
S174 RDTGILDSIGRFFGG
R177 GILDSIGRFFGGDRG
G180 DSIGRFFGGDRGAPK
G181 SIGRFFGGDRGAPKR
R183 GRFFGGDRGAPKRGs
S190‑p RGAPKRGsGKVSSEE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K192 APKRGsGKVSSEE__
S194 KRGsGKVSSEE____
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  MBP iso3  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRHG
S8 MASQKRPSQRHGSKY
S13 RPSQRHGSKYLATAS
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
Y15 SQRHGSKYLATASTM
T18 HGSKYLATASTMDHA
S20 SKYLATASTMDHARH
T21 KYLATASTMDHARHG
T36 FLPRHRDTGILDSIG
S41 RDTGILDSIGRFFGG
S41 RDTGILDSIGRFFGG
R44 GILDSIGRFFGGDRG
G47 DSIGRFFGGDRGAPK
G48 SIGRFFGGDRGAPKR
R50 GRFFGGDRGAPKRGs
S57‑p RGAPKRGsGKVPWLK
K64 sGKVPWLKPGRsPLP
K64 sGKVPWLKPGRsPLP
G66 KVPWLKPGRsPLPSH
S68‑p PWLKPGRsPLPSHAR
S72 PGRsPLPSHARSQPG
R75 sPLPSHARSQPGLCN
Y84 QPGLCNMYKDSHHPA
K85 PGLCNMYKDSHHPAR
K85 PGLCNMYKDSHHPAR
S87 LCNMYKDSHHPARTA
A91 YKDSHHPARTAHYGS
T93 DSHHPARTAHYGSLP
A94 SHHPARTAHYGSLPQ
Y96 HPARTAHYGSLPQKS
S98 ARTAHYGSLPQKSHG
S98 ARTAHYGSLPQKSHG
K102 HYGSLPQKSHGRTQD
K102 HYGSLPQKSHGRTQD
S103 YGSLPQKSHGRTQDE
T107 PQKSHGRTQDENPVV
T107 PQKSHGRTQDENPVV
K118 NPVVHFFKNIVTPRT
K118 NPVVHFFKNIVTPRT
T122 HFFKNIVTPRTPPPS
T125 KNIVTPRTPPPSQGK
K132 TPPPSQGKGRGLSLS
R134 PPSQGKGRGLSLSRF
R134 PPSQGKGRGLSLSRF
S137 QGKGRGLSLSRFSWG
S142 GLSLSRFSWGAEGQR
R149 SWGAEGQRPGFGYGG
R149 SWGAEGQRPGFGYGG
Y154 GQRPGFGYGGRASDY
R157 PGFGYGGRASDYKSA
S159 FGYGGRASDYKSAHK
K169 KSAHKGFKGVDAQGT
K169 KSAHKGFKGVDAQGT
- gap
- gap
T176 KGVDAQGTLSKIFKL
S178 VDAQGTLSKIFKLGG
K179 DAQGTLSKIFKLGGR
K182 GTLSKIFKLGGRDSR
S188 FKLGGRDSRSGSPMA
- gap
S190 LGGRDSRSGSPMARR
S192 GRDSRSGSPMARR__
  MBP iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRHG
S8 MASQKRPSQRHGSKY
S13 RPSQRHGSKYLATAS
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
Y15 SQRHGSKYLATASTM
T18 HGSKYLATASTMDHA
S20 SKYLATASTMDHARH
T21 KYLATASTMDHARHG
T36 FLPRHRDTGILDSIG
S41 RDTGILDSIGRFFGG
S41 RDTGILDSIGRFFGG
R44 GILDSIGRFFGGDRG
G47 DSIGRFFGGDRGAPK
G48 SIGRFFGGDRGAPKR
R50 GRFFGGDRGAPKRGs
S57‑p RGAPKRGsGKVPWLK
K64 sGKVPWLKPGRsPLP
K64 sGKVPWLKPGRsPLP
G66 KVPWLKPGRsPLPSH
S68‑p PWLKPGRsPLPSHAR
S72 PGRsPLPSHARSQPG
R75 sPLPSHARSQPGLCN
Y84 QPGLCNMYKDSHHPA
K85 PGLCNMYKDSHHPAR
K85 PGLCNMYKDSHHPAR
S87 LCNMYKDSHHPARTA
A91 YKDSHHPARTAHYGS
T93 DSHHPARTAHYGSLP
A94 SHHPARTAHYGSLPQ
Y96 HPARTAHYGSLPQKS
S98 ARTAHYGSLPQKSHG
S98 ARTAHYGSLPQKSHG
K102 HYGSLPQKSHGRTQD
K102 HYGSLPQKSHGRTQD
S103 YGSLPQKSHGRTQDE
T107 PQKSHGRTQDENPVV
T107 PQKSHGRTQDENPVV
K118 NPVVHFFKNIVTPRT
K118 NPVVHFFKNIVTPRT
T122 HFFKNIVTPRTPPPS
T125 KNIVTPRTPPPSQGK
K132 TPPPSQGKGAEGQRP
- gap
- gap
- gap
- gap
R138 GKGAEGQRPGFGYGG
R138 GKGAEGQRPGFGYGG
Y143 GQRPGFGYGGRASDY
R146 PGFGYGGRASDYKSA
S148 FGYGGRASDYKSAHK
K158 KSAHKGFKGVDAQGT
K158 KSAHKGFKGVDAQGT
- gap
- gap
T165 KGVDAQGTLSKIFKL
S167 VDAQGTLSKIFKLGG
K168 DAQGTLSKIFKLGGR
K171 GTLSKIFKLGGRDSR
S177 FKLGGRDSRSGSPMA
- gap
S179 LGGRDSRSGSPMARR
S181 GRDSRSGSPMARR__
  MBP iso5  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRHG
S8 MASQKRPSQRHGSKY
S13 RPSQRHGSKYLATAS
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
K14 PSQRHGSKYLATAST
Y15 SQRHGSKYLATASTM
T18 HGSKYLATASTMDHA
S20 SKYLATASTMDHARH
T21 KYLATASTMDHARHG
T36 FLPRHRDTGILDSIG
S41 RDTGILDSIGRFFGG
S41 RDTGILDSIGRFFGG
R44 GILDSIGRFFGGDRG
G47 DSIGRFFGGDRGAPK
G48 SIGRFFGGDRGAPKR
R50 GRFFGGDRGAPKRGS
S57 RGAPKRGSGKDSHHP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K59 APKRGSGKDSHHPAR
S61 KRGSGKDSHHPARTA
A65 GKDSHHPARTAHYGS
T67 DSHHPARTAHYGSLP
A68 SHHPARTAHYGSLPQ
Y70 HPARTAHYGSLPQKS
S72 ARTAHYGSLPQKSHG
S72 ARTAHYGSLPQKSHG
K76 HYGSLPQKSHGRTQD
K76 HYGSLPQKSHGRTQD
S77 YGSLPQKSHGRTQDE
T81 PQKSHGRTQDENPVV
T81 PQKSHGRTQDENPVV
K92 NPVVHFFKNIVTPRT
K92 NPVVHFFKNIVTPRT
T96 HFFKNIVTPRTPPPS
T99 KNIVTPRTPPPSQGK
K106 TPPPSQGKGRGLSLS
R108 PPSQGKGRGLSLSRF
R108 PPSQGKGRGLSLSRF
S111 QGKGRGLSLSRFSWG
S116 GLSLSRFSWGAEGQR
R123 SWGAEGQRPGFGYGG
R123 SWGAEGQRPGFGYGG
Y128 GQRPGFGYGGRASDY
R131 PGFGYGGRASDYKSA
S133 FGYGGRASDYKSAHK
K143 KSAHKGFKGVDAQGT
K143 KSAHKGFKGVDAQGT
- gap
- gap
T150 KGVDAQGTLSKIFKL
S152 VDAQGTLSKIFKLGG
K153 DAQGTLSKIFKLGGR
K156 GTLSKIFKLGGRDsR
S162‑p FKLGGRDsRSGSPMA
- gap
S164 LGGRDsRSGSPMARR
S166 GRDsRSGSPMARR__
  mouse

► Hide Isoforms
 
S5‑p ___MGNHsGKRELSA
S16 ELSAEKASKDGEIHR
G19 AEKASKDGEIHRGEA
A26 GEIHRGEAGKKRsVG
S31‑p GEAGKKRsVGKLsQT
S36‑p KRsVGKLsQTAsEDs
T38 sVGKLsQTAsEDsDV
A39 VGKLsQTAsEDsDVF
S40‑p GKLsQTAsEDsDVFG
S43‑p sQTAsEDsDVFGEAD
N87 AHPADPGNRPHLIRL
S96‑p PHLIRLFsRDAPGRE
T106 APGREDNTFKDRPsE
S112‑p NTFKDRPsEsDELQT
S114‑p FKDRPsEsDELQTIQ
K138‑ub LDVMASQkRPSQRsk
S141 MASQkRPSQRskyLA
S144‑p QkRPSQRskyLAtAs
K145‑m1 kRPSQRskyLAtAst
K145‑ac kRPSQRskyLAtAst
K145‑ub kRPSQRskyLAtAst
Y146‑p RPSQRskyLAtAstM
T149‑p QRskyLAtAstMDHA
S151‑p skyLAtAstMDHARH
T152‑p kyLAtAstMDHARHG
T167‑p FLPRHRDtGILDsIG
S172‑p RDtGILDsIGrFFsG
S172‑gl RDtGILDsIGrFFsG
R175‑m1 GILDsIGrFFsGDrG
S178‑p DsIGrFFsGDrGAPK
G179 sIGrFFsGDrGAPKR
R181‑m1 GrFFsGDrGAPKRGs
S188‑p rGAPKRGsGKDsHtR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K190 APKRGsGKDsHtRtt
S192‑p KRGsGKDsHtRttHy
T194‑p GsGKDsHtRttHyGs
T196‑p GKDsHtRttHyGsLP
T197‑p KDsHtRttHyGsLPQ
Y199‑p sHtRttHyGsLPQks
S201‑p tRttHyGsLPQksQH
S201‑gl tRttHyGsLPQksQH
K205‑ac HyGsLPQksQHGRtQ
K205‑ub HyGsLPQksQHGRtQ
S206‑p yGsLPQksQHGRtQD
T211‑p QksQHGRtQDENPVV
T211‑gl QksQHGRtQDENPVV
K222‑ac NPVVHFFkNIVtPRt
K222‑ub NPVVHFFkNIVtPRt
T226‑p HFFkNIVtPRtPPPS
T229‑p kNIVtPRtPPPSQGK
K236 tPPPSQGKGGRDSRs
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S241 QGKGGRDSRsGsPMA
- gap
S243‑p KGGRDSRsGsPMARR
S245‑p GRDSRsGsPMARR__
  MBP iso5  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRSK
S8 MASQKRPSQRSKYLA
S11 QKRPSQRSKYLATAS
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
Y13 RPSQRSKYLATASTM
T16 QRSKYLATASTMDHA
S18 SKYLATASTMDHARH
T19 KYLATASTMDHARHG
T34 FLPRHRDTGILDSIG
S39 RDTGILDSIGRFFSG
S39 RDTGILDSIGRFFSG
R42 GILDSIGRFFSGDRG
S45 DSIGRFFSGDRGAPK
G46 SIGRFFSGDRGAPKR
R48 GRFFSGDRGAPKRGS
S55 RGAPKRGSGKDSHTR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K57 APKRGSGKDSHTRTT
S59 KRGSGKDSHTRTTHY
T61 GSGKDSHTRTTHYGS
T63 GKDSHTRTTHYGSLP
T64 KDSHTRTTHYGSLPQ
Y66 SHTRTTHYGSLPQKS
S68 TRTTHYGSLPQKSQH
S68 TRTTHYGSLPQKSQH
K72 HYGSLPQKSQHGRTQ
K72 HYGSLPQKSQHGRTQ
S73 YGSLPQKSQHGRTQD
T78 QKSQHGRTQDENPVV
T78 QKSQHGRTQDENPVV
K89 NPVVHFFKNIVtPRt
K89 NPVVHFFKNIVtPRt
T93‑p HFFKNIVtPRtPPPS
T96‑p KNIVtPRtPPPSQGK
K103 tPPPSQGKGrGLsLS
R105‑m1 PPSQGKGrGLsLSRF
R105‑m2 PPSQGKGrGLsLSRF
S108‑p QGKGrGLsLSRFsWG
S113‑p GLsLSRFsWGAEGQk
K120‑ac sWGAEGQkPGFGyGG
K120‑ub sWGAEGQkPGFGyGG
Y125‑p GQkPGFGyGGrASDY
R128‑m1 PGFGyGGrASDYKSA
S130 FGyGGrASDYKSAHK
K140 KSAHKGFKGAyDAQG
K140‑ub KSAHKGFkGAyDAQG
- gap
Y143‑p HKGFkGAyDAQGtLs
T148‑p GAyDAQGtLsKIFKL
S150‑p yDAQGtLsKIFKLGG
K151 DAQGtLsKIFKLGGR
K154 GtLsKIFKLGGRDSR
S160 FKLGGRDSRSGSPMA
- gap
S162 LGGRDSRSGSPMARR
S164 GRDSRSGSPMARR__
  MBP iso6  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRSK
S8 MASQKRPSQRSKYLA
S11 QKRPSQRSKYLATAS
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
Y13 RPSQRSKYLATASTM
T16 QRSKYLATASTMDHA
S18 SKYLATASTMDHARH
T19 KYLATASTMDHARHG
T34 FLPRHRDTGILDSIG
S39 RDTGILDSIGRFFSG
S39 RDTGILDSIGRFFSG
R42 GILDSIGRFFSGDRG
S45 DSIGRFFSGDRGAPK
G46 SIGRFFSGDRGAPKR
R48 GRFFSGDRGAPKRGs
S55‑p RGAPKRGsGKVPWLk
K62 sGKVPWLKQsRsPLP
K62‑ub sGKVPWLkQsRsPLP
S64‑p KVPWLkQsRsPLPsH
S66‑p PWLkQsRsPLPsHAr
S70‑p QsRsPLPsHArSRPG
R73‑m1 sPLPsHArSRPGLCH
Y82 RPGLCHMYkDSHTRT
K83 PGLCHMYKDSHTRTT
K83‑m1 PGLCHMYkDSHTRTT
S85 LCHMYkDSHTRTTHY
T87 HMYkDSHTRTTHYGS
T89 YkDSHTRTTHYGSLP
T90 kDSHTRTTHYGSLPQ
Y92 SHTRTTHYGSLPQKS
S94 TRTTHYGSLPQKSQH
S94 TRTTHYGSLPQKSQH
K98 HYGSLPQKSQHGRTQ
K98 HYGSLPQKSQHGRTQ
S99 YGSLPQKSQHGRTQD
T104 QKSQHGRTQDENPVV
T104 QKSQHGRTQDENPVV
K115 NPVVHFFKNIVTPRt
K115 NPVVHFFKNIVTPRt
T119 HFFKNIVTPRtPPPS
T122‑p KNIVTPRtPPPSQGK
K129 tPPPSQGKGrGLsLS
R131‑m1 PPSQGKGrGLsLSRF
R131‑m2 PPSQGKGrGLsLSRF
S134‑p QGKGrGLsLSRFsWG
S139‑p GLsLSRFsWGGRDsR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S145‑p FsWGGRDsRsGSPMA
- gap
S147‑p WGGRDsRsGSPMARR
S149 GRDsRsGSPMARR__
  MBP iso8  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRSK
S8 MASQKRPSQRSKYLA
S11 QKRPSQRSKYLATAS
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
Y13 RPSQRSKYLATASTM
T16 QRSKYLATASTMDHA
S18 SKYLATASTMDHARH
T19 KYLATASTMDHARHG
T34 FLPRHRDTGILDSIG
S39 RDTGILDSIGRFFSG
S39 RDTGILDSIGRFFSG
R42 GILDSIGRFFSGDRG
S45 DSIGRFFSGDRGAPK
G46 SIGRFFSGDRGAPKR
R48 GRFFSGDRGAPKRGS
S55 RGAPKRGSGKDSHTR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K57 APKRGSGKDSHTRTT
S59 KRGSGKDSHTRTTHY
T61 GSGKDSHTRTTHYGS
T63 GKDSHTRTTHYGSLP
T64 KDSHTRTTHYGSLPQ
Y66 SHTRTTHYGSLPQKS
S68 TRTTHYGSLPQKSQH
S68 TRTTHYGSLPQKSQH
K72 HYGSLPQKSQHGRTQ
K72 HYGSLPQKSQHGRTQ
S73 YGSLPQKSQHGRTQD
T78 QKSQHGRTQDENPVV
T78 QKSQHGRTQDENPVV
K89 NPVVHFFKNIVTPRt
K89 NPVVHFFKNIVTPRt
T93 HFFKNIVTPRtPPPS
T96‑p KNIVTPRtPPPSQGK
K103 tPPPSQGKGrGLsLS
R105‑m1 PPSQGKGrGLsLSRF
R105‑m2 PPSQGKGrGLsLSRF
S108‑p QGKGrGLsLSRFsWG
S113‑p GLsLSRFsWGGRDsR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S119‑p FsWGGRDsRsGSPMA
- gap
S121‑p WGGRDsRsGSPMARR
S123 GRDsRsGSPMARR__
  MBP iso10  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRSK
S8 MASQKRPSQRSKYLA
S11 QKRPSQRSKYLATAS
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
K12 KRPSQRSKYLATAST
Y13 RPSQRSKYLATASTM
T16 QRSKYLATASTMDHA
S18 SKYLATASTMDHARH
T19 KYLATASTMDHARHG
T34 FLPRHRDTGILDSIG
S39 RDTGILDSIGRFFSG
S39 RDTGILDSIGRFFSG
R42 GILDSIGRFFSGDRG
S45 DSIGRFFSGDRGAPK
G46 SIGRFFSGDRGAPKR
R48 GRFFSGDRGAPKRGS
S55 RGAPKRGSGKDSHTR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K57 APKRGSGKDSHTRTT
S59 KRGSGKDSHTRTTHY
T61 GSGKDSHTRTTHYGS
T63 GKDSHTRTTHYGSLP
T64 KDSHTRTTHYGSLPQ
Y66 SHTRTTHYGSLPQKS
S68 TRTTHYGSLPQKSQH
S68 TRTTHYGSLPQKSQH
K72 HYGSLPQKSQHGRTQ
K72 HYGSLPQKSQHGRTQ
S73 YGSLPQKSQHGRTQD
T78 QKSQHGRTQDENPVV
T78 QKSQHGRTQDENPVV
K89 NPVVHFFKNIVtPRt
K89 NPVVHFFKNIVtPRt
T93‑p HFFKNIVtPRtPPPS
T96‑p KNIVtPRtPPPSQGK
K103 tPPPSQGKDFVPGDH
R127‑m1 SFSSSQGrGLsLSRF
R127‑m2 SFSSSQGrGLsLSRF
S130‑p SSQGrGLsLSRFsWG
S135‑p GLsLSRFsWGAEGQk
K142‑ac sWGAEGQkPGFGyGG
K142‑ub sWGAEGQkPGFGyGG
Y147‑p GQkPGFGyGGrASDY
R150‑m1 PGFGyGGrASDYKSA
S152 FGyGGrASDYKSAHK
K162 KSAHKGFKGAyDAQG
K162‑ub KSAHKGFkGAyDAQG
- gap
Y165‑p HKGFkGAyDAQGtLs
T170‑p GAyDAQGtLsKIFKL
S172‑p yDAQGtLsKIFKLGG
K173 DAQGtLsKIFKLGGR
K176 GtLsKIFKLGGRDSR
S182 FKLGGRDSRSGSPMA
- gap
S184 LGGRDSRSGSPMARR
S186 GRDSRSGSPMARR__
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K5 ___MASQKRPSQRHG
S8 MASQKRPSQRHGSky
S13 RPSQRHGSkyLAtAs
K14 PSQRHGSKyLAtAst
K14‑ac PSQRHGSkyLAtAst
K14 PSQRHGSKyLAtAst
Y15‑p SQRHGSkyLAtAstM
T18‑p HGSkyLAtAstMDHA
S20‑p SkyLAtAstMDHARH
T21‑p kyLAtAstMDHARHG
T36‑p FLPRHRDtGILDsIG
S41‑p RDtGILDsIGRFFsG
S41 RDtGILDSIGRFFsG
R44 GILDsIGRFFsGDRG
S47‑p DsIGRFFsGDRGAPK
G48 sIGRFFsGDRGAPKR
R50 GRFFsGDRGAPKRGS
S57 RGAPKRGSGKVPWLk
K64‑ac SGKVPWLkQSRSPLP
K64 SGKVPWLKQSRSPLP
S66 KVPWLkQSRSPLPSH
S68 PWLkQSRSPLPSHAR
S72 QSRSPLPSHARSRPG
R75 SPLPSHARSRPGLCH
Y84‑p RPGLCHMykDSHTRT
K85‑ac PGLCHMykDSHTRTT
K85 PGLCHMyKDSHTRTT
S87 LCHMykDSHTRTTHy
T89 HMykDSHTRTTHyGs
T91 ykDSHTRTTHyGsLP
T92 kDSHTRTTHyGsLPQ
Y94‑p SHTRTTHyGsLPQks
S96‑p TRTTHyGsLPQksQR
S96 TRTTHyGSLPQksQR
K100‑ac HyGsLPQksQRtQDE
K100‑ub HyGsLPQksQRtQDE
S101‑p yGsLPQksQRtQDEN
T104‑p LPQksQRtQDENPVV
T104 LPQksQRTQDENPVV
K115‑ac NPVVHFFkNIVTPRt
K115‑ub NPVVHFFkNIVTPRt
T119 HFFkNIVTPRtPPPS
T122‑p kNIVTPRtPPPSQGk
K129‑m1 tPPPSQGkGrGLSLS
R131‑m1 PPSQGkGrGLSLSRF
R131 PPSQGkGRGLSLSRF
S134 QGkGrGLSLSRFSWG
S139 GLSLSRFSWGAEGQk
K146‑ac SWGAEGQkPGFGyGG
K146 SWGAEGQKPGFGyGG
Y151‑p GQkPGFGyGGRASDY
R154 PGFGyGGRASDYKSA
S156 FGyGGRASDYKSAHK
K166‑ac KSAHKGFkGAyDAQG
K166 KSAHKGFKGAyDAQG
- gap
Y169‑p HKGFkGAyDAQGTLS
T174 GAyDAQGTLSkIFkL
S176 yDAQGTLSkIFkLGG
K177‑ac DAQGTLSkIFkLGGR
K180‑ac GTLSkIFkLGGRDSR
S186 FkLGGRDSRSGSPMA
- gap
S188 LGGRDSRSGSPMARR
S190 GRDSRSGSPMARR__
  rabbit

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K4 ____ASQKRPsQRHG
S7‑p _ASQKRPsQRHGSKY
S12 RPsQRHGSKYLATAS
K13 PsQRHGSKYLATAST
K13 PsQRHGSKYLATAST
K13 PsQRHGSKYLATAST
Y14 sQRHGSKYLATASTM
T17 HGSKYLATASTMDHA
S19 SKYLATASTMDHARH
T20 KYLATASTMDHARHG
T35 FLPRHRDTGILDSIG
S40 RDTGILDSIGRFFSS
S40 RDTGILDSIGRFFSS
R43 GILDSIGRFFSSDRG
S46 DSIGRFFSSDRGAPK
S47 SIGRFFSSDRGAPKR
R49 GRFFSSDRGAPKRGs
S56‑p RGAPKRGsGKDHAAR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K58 APKRGsGKDHAARTt
- gap
A62 GsGKDHAARTtHYGS
T64 GKDHAARTtHYGSLP
T65‑p KDHAARTtHYGSLPQ
Y67 HAARTtHYGSLPQKS
S69 ARTtHYGSLPQKSGH
S69 ARTtHYGSLPQKSGH
K73 HYGSLPQKSGHRPQD
K73 HYGSLPQKSGHRPQD
S74 YGSLPQKSGHRPQDE
P78 PQKSGHRPQDENPVV
P78 PQKSGHRPQDENPVV
K89 NPVVHFFKNIVTPRt
K89 NPVVHFFKNIVTPRt
T93 HFFKNIVTPRtPPPS
T96‑p KNIVTPRtPPPSQGK
K103 tPPPSQGKGRGTVLS
R105 PPSQGKGRGTVLSRF
R105 PPSQGKGRGTVLSRF
V108 QGKGRGTVLSRFsWG
S113‑p GTVLSRFsWGAEGQK
K120 sWGAEGQKPGFGYGG
K120 sWGAEGQKPGFGYGG
Y125 GQKPGFGYGGRAADY
R128 PGFGYGGRAADYKSA
A130 FGYGGRAADYKSAHK
K140 KSAHKGLKGADAQGT
K140 KSAHKGLKGADAQGT
- gap
- gap
T147 KGADAQGTLSRLFKL
S149 ADAQGTLSRLFKLGG
R150 DAQGTLSRLFKLGGR
K153 GTLSRLFKLGGRDSR
S159 FKLGGRDSRSGsPMA
- gap
S161 LGGRDSRSGsPMARR
S163‑p GRDSRSGsPMARR__