a small G protein of the Ras family with tumor suppressor activity. Induces morphological reversion of a cell line transformed by a Ras oncogene. Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Interacts with SGSM1, SGSM2 and SGSM3. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Tumor suppressor
Cellular Component: cell junction; cytoplasm; cytosol; early endosome; late endosome; perinuclear region of cytoplasm; plasma membrane
Molecular Function: protein binding; protein complex binding; protein transporter activity; Rap guanyl-nucleotide exchange factor activity
Biological Process: activation of MAPKK activity; microvillus biogenesis; neutrophil degranulation; positive regulation of GTPase activity; positive regulation of protein kinase activity; protein transport; Rap protein signal transduction; regulation of insulin secretion; signal transduction
Alt. Names/Synonyms: C21KG; G-22K; GTP-binding protein smg p21A; KREV-1; KREV1; RAP1; RAP1A; RAP1A, member of RAS oncogene family; Ras-related protein Krev-1; Ras-related protein Rap-1A; RAS-related protein RAP1A; SMGP21