a small G protein of the Ras family with tumor suppressor activity. Induces morphological reversion of a cell line transformed by a Ras oncogene. Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Interacts with SGSM1, SGSM2 and SGSM3. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Ras; G protein; Motility/polarity/chemotaxis; Tumor suppressor
Cellular Component: cell junction; cytoplasm; cytosol; early endosome; late endosome; myelin sheath; neuron projection; perinuclear region of cytoplasm; plasma membrane
Molecular Function: GTP binding; GTPase activity; protein binding; protein complex binding; protein transporter activity; Rap guanyl-nucleotide exchange factor activity; Ras GTPase binding
Biological Process: activation of MAPKK activity; intracellular protein transport; metabolic process; microvillus biogenesis; negative regulation of collagen biosynthetic process; nucleocytoplasmic transport; positive regulation of glucose import; positive regulation of GTPase activity; positive regulation of phagocytosis; positive regulation of protein kinase activity; protein transport; Rap protein signal transduction; regulation of insulin secretion; signal transduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.