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Protein Page:
RAP1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RAP1A a small G protein of the Ras family with tumor suppressor activity. Induces morphological reversion of a cell line transformed by a Ras oncogene. Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Interacts with SGSM1, SGSM2 and SGSM3. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; G protein, monomeric; Motility/polarity/chemotaxis; G protein; G protein, monomeric, Ras
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component: cell junction; cytoplasm; cytosol; early endosome; late endosome; perinuclear region of cytoplasm; plasma membrane
Molecular Function: protein binding; protein complex binding; protein transporter activity; Rap guanyl-nucleotide exchange factor activity
Biological Process: activation of MAPKK activity; microvillus biogenesis; positive regulation of GTPase activity; positive regulation of protein kinase activity; protein transport; Rap protein signal transduction; regulation of insulin secretion; signal transduction
Reference #:  P62834 (UniProtKB)
Alt. Names/Synonyms: C21KG; G-22K; GTP-binding protein smg p21A; KREV-1; KREV1; RAP1; RAP1A; RAP1A, member of RAS oncogene family; Ras-related protein Krev-1; Ras-related protein Rap-1A; RAS-related protein RAP1A; SMGP21
Gene Symbols: RAP1A
Molecular weight: 20,987 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RAP1A

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 K5‑ub ___MREYkLVVLGsG
0 7 S11‑p YkLVVLGsGGVGKSA
0 57 K31‑ub VQGIFVEkYDPTIED
0 10 S39‑p YDPTIEDsyRKQVEV
0 3 Y40‑p DPTIEDsyRKQVEVD
0 1 K117 PMILVGNKCDLEDER
0 2 K128‑ub EDERVVGkEQGQNLA
0 1 K149 AFLESSAKSKINVNE
0 1 K151 LESSAKSKINVNEIF
0 77 Y159‑p INVNEIFyDLVRQIN
1 0 S180‑p KKKPKKKsCLLL___
  mouse

 
K5‑ub ___MREYkLVVLGSG
S11 YkLVVLGSGGVGKSA
K31‑ub VQGIFVEkYDPTIED
S39‑p YDPTIEDsYRKQVEV
Y40 DPTIEDsYRKQVEVD
K117‑ub PMILVGNkCDLEDER
K128‑ub EDERVVGkEQGQNLA
K149‑ub AFLESSAkSKINVNE
K151 LESSAkSKINVNEIF
Y159‑p INVNEIFyDLVRQIN
S180 KKKPKKKSCLLL___
  rat

 
K5 ___MREYKLVVLGSG
S11 YKLVVLGSGGVGKSA
K31‑ub VQGIFVEkYDPTIED
S39 YDPTIEDSYRKQVEV
Y40 DPTIEDSYRKQVEVD
K117 PMILVGNKCDLEDER
K128 EDERVVGKEQGQNLA
K149 AFLESSAKSkINVNE
K151‑ac LESSAKSkINVNEIF
Y159‑p INVNEIFyDLVRQIN
S180 KKKPKKKSCLLL___
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