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Protein Page:
CDC6 (human)

Overview
CDC6 Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.3
Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; spindle midzone; spindle pole
Molecular Function: kinase binding; nucleotide binding; protein binding
Biological Process: DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; positive regulation of chromosome segregation; positive regulation of cytokinesis; regulation of cyclin-dependent protein kinase activity; regulation of mitotic metaphase/anaphase transition; traversing start control point of mitotic cell cycle
Disease: Meier-gorlin Syndrome 5
Reference #:  Q99741 (UniProtKB)
Alt. Names/Synonyms: CDC18 (cell division cycle 18, S.pombe, homolog)-like; Cdc18-related protein; CDC18L; CDC6; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6 homolog (S. cerevisiae); cell division cycle 6 protein; HsCdc18; HsCDC6; p62(cdc6)
Gene Symbols: CDC6
Molecular weight: 62,720 Da
Basal Isoelectric point: 9.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDC6

Protein Structure Not Found.
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