an AGC kinase of the PKC family. An atypical PKC: its activity is not regulated by Ca2+, PS, DAG or phorbol esters. Constitutively active. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 184.108.40.206; Kinase, protein; AGC group; PKC family; Iota subfamily
Molecular Function: ATP binding; insulin receptor substrate binding; metal ion binding; phospholipase binding; potassium channel regulator activity; protein binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: actin cytoskeleton reorganization; activation of NF-kappaB transcription factor; activation of protein kinase B; cell migration; establishment of cell polarity; inflammatory response; insulin receptor signaling pathway; long-term memory; membrane depolarization; membrane hyperpolarization; microtubule cytoskeleton organization and biogenesis; negative regulation of apoptosis; negative regulation of hydrolase activity; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein complex assembly; peptidyl-serine phosphorylation; phospholipase D activation; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of glucose import; positive regulation of insulin receptor signaling pathway; positive regulation of interleukin-4 production; positive regulation of T-helper 2 cell differentiation; protein amino acid phosphorylation; protein heterooligomerization; signal transduction; transforming growth factor beta receptor signaling pathway; vesicle transport along microtubule
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.