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Protein Page:
CTNNB1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTNNB1 a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor; Oncoprotein; Cell adhesion; Nuclear receptor co-regulator; Actin-binding
Cellular Component: adherens junction; apical junction complex; apical part of cell; basolateral plasma membrane; beta-catenin destruction complex; catenin complex; cell cortex; cell junction; cell projection membrane; cell-cell adherens junction; centrosome; cytoplasm; cytosol; dendritic shaft; fascia adherens; flotillin complex; focal adhesion; intercellular junction; lamellipodium; lateral plasma membrane; membrane; microvillus membrane; neuron projection; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; synapse; tight junction; transcription factor complex; Z disc
Molecular Function: alpha-catenin binding; cadherin binding; chromatin binding; DNA binding; double-stranded DNA binding; enzyme binding; estrogen receptor binding; ionotropic glutamate receptor binding; kinase binding; nitric-oxide synthase binding; nuclear hormone receptor binding; protein binding; protein C-terminus binding; protein complex binding; protein heterodimerization activity; protein kinase binding; protein phosphatase binding; SMAD binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: anterior/posterior axis specification; bone resorption; cardiac muscle cell proliferation; cell adhesion; cell differentiation; cell fate determination; cell fate specification; cell maturation; cell proliferation; cell-cell adhesion; cell-matrix adhesion; cellular morphogenesis during differentiation; cellular process; central nervous system vasculogenesis; chromatin-mediated maintenance of transcription; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; endoderm formation; endodermal cell fate commitment; fallopian tube development; forebrain development; gastrulation with mouth forming second; genitalia morphogenesis; glial cell fate determination; hair cycle process; hair follicle morphogenesis; heart development; hemopoiesis; hindbrain development; in utero embryonic development; kidney development; layer formation in the cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung development; male genitalia development; midbrain development; morphogenesis of embryonic epithelium; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of mitotic cell cycle, embryonic; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of protein sumoylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural plate development; neuron differentiation; neuron migration; odontogenesis of dentine-containing teeth; oocyte development; organ development; osteoclast differentiation; pancreas development; patterning of blood vessels; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptosis; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle development; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein heterooligomerization; proximal/distal pattern formation; regulation of apoptosis; regulation of cell differentiation; regulation of cell proliferation; regulation of centriole-centriole cohesion; regulation of epithelial cell differentiation; regulation of gene expression; regulation of histone H3-K4 methylation; regulation of myelination; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of smooth muscle cell proliferation; regulation of T cell proliferation; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to cytokine stimulus; response to estradiol stimulus; response to estrogen stimulus; Schwann cell proliferation; skeletal development; skin development; smooth muscle cell differentiation; stem cell maintenance; synapse organization and biogenesis; synaptic transmission; synaptic vesicle transport; T cell differentiation; T cell differentiation in the thymus; thymus development; ureteric bud branching; vasculature development; vasculogenesis; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Reference #:  Q02248 (UniProtKB)
Alt. Names/Synonyms: Beta-catenin; catenin (cadherin associated protein), beta 1; Catenin beta-1; Catnb; CTNB1; Ctnnb1; Mesc; OTTMUSP00000017750
Gene Symbols: Ctnnb1
Molecular weight: 85,471 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTNNB1

Protein Structure Not Found.
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STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA


Sites Implicated In
cell adhesion, altered: Y142‑p, Y654‑p
cell motility, altered: Y654‑p
cytoskeletal reorganization: Y654‑p
transcription, altered: S33‑p, S552‑p, Y654‑p
activity, induced: S33‑p
intracellular localization: S191‑p, S552‑p, S605‑p, Y654‑p
molecular association, regulation: Y142‑p, Y654‑p
protein degradation: S29‑p, S33‑p, S37‑p, T41‑p, S45‑p
protein stabilization: S675‑p
ubiquitination: S29‑p, S33‑p, S37‑p, T41‑p, S45‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 K19 MAMEPDRKAAVsHWQ
1 3 K19‑ub MAMEPDRkAAVsHWQ
2 0 S23‑p PDRkAAVsHWQQQsY
0 1 S23‑gl PDRkAAVsHWQQQsY
3 4 S29‑p VsHWQQQsYLDsGIH
0 38 Y30 sHWQQQsYLDsGIHs
64 5 S33‑p QQQsYLDsGIHsGAT
66 14 S37‑p YLDsGIHsGATtTAP
56 2 T41‑p GIHsGATtTAPsLSG
27 4 S45‑p GATtTAPsLSGkGNP
0 1 S47 TtTAPsLSGkGNPEE
6 0 K49‑ac TAPsLSGkGNPEEED
1 0 K49 TAPsLSGKGNPEEED
1 0 Y64 VDTSQVLYEWEQGFS
1 0 S73 WEQGFSQSFTQEQVA
6 23 Y86‑p VADIDGQyAMTRAQR
2 0 T102 RAAMFPETLDEGMQI
2 0 T112 EGMQIPSTQFDAAHP
0 1 D115 QIPSTQFDAAHPTNV
3 0 T120 QFDAAHPTNVQRLAE
0 7 K133‑ub AEPSQMLkHAVVNLI
11 1 Y142‑p AVVNLINyQDDAELA
0 3 K158‑ub RAIPELTkLLNDEDQ
0 9 K170‑ub EDQVVVNkAAVMVHQ
0 2 S179 AVMVHQLSKKEASRH
0 6 K180 VMVHQLSKKEASRHA
4 46 S191‑p SRHAIMRsPQMVSAI
0 2 S196 MRsPQMVSAIVRTMQ
0 1 S222 AGTLHNLSHHREGLL
0 13 K233‑ub EGLLAIFkSGGIPAL
3 0 S246 ALVKMLGSPVDSVLF
1 1 Y331 LVNIMRTYTYEKLLW
1 0 T332 VNIMRTYTYEKLLWT
2 1 Y333 NIMRTYTYEKLLWTT
0 3 K335 MRTYTYEKLLWTTSR
2 0 K345 WTTSRVLKVLSVCSS
0 1 K345 WTTSRVLKVLSVCSS
1 0 K354 LSVCSSNKPAIVEAG
0 6 K354 LSVCSSNKPAIVEAG
2 0 T393‑p RNLSDAAtKQEGMEG
1 0 K394 NLSDAAtKQEGMEGL
0 1 K435 TCNNYKNKMMVCQVG
0 6 K435 TCNNYKNKMMVCQVG
1 1 T472 ICALRHLTSRHQEAE
0 1 S473 CALRHLTSRHQEAEM
1 90 Y489‑p QNAVRLHyGLPVVVK
0 31 K508 PSHWPLIKATVGLIR
0 1 T510 HWPLIKATVGLIRNL
0 1 T547 LVRAHQDTQRRtsMG
0 16 T551‑p HQDTQRRtsMGGtQQ
15 54 S552‑p QDTQRRtsMGGtQQQ
0 21 T556‑p RRtsMGGtQQQFVEG
0 2 T574 EEIVEGCTGALHILA
3 0 S605‑p LFVQLLYsPIENIQR
0 6 K625‑ub LCELAQDkEAAEAIE
1 0 S646 PLTELLHSRNEGVAT
0 1 T653 SRNEGVATyAAAVLF
16 21 Y654‑p RNEGVATyAAAVLFR
2 15 Y670 SEDKPQDYkKRLsVE
0 4 K671‑ub EDKPQDYkKRLsVEL
16 51 S675‑p QDYkKRLsVELtSsL
0 3 T679‑p KRLsVELtSsLFRtE
0 1 S680 RLsVELtSsLFRtEP
0 1 S681‑p LsVELtSsLFRtEPM
0 1 T685‑p LtSsLFRtEPMAWNE
0 1 T693‑p EPMAWNEtADLGLDI
1 1 S715 GYRQDDPSYRSFHSG
0 36 Y716 YRQDDPSYRSFHSGG
1 4 S718 QDDPSYRSFHSGGYG
0 2 S721 PSYRSFHSGGYGQDA
0 1 Y724 RSFHSGGYGQDALGM
0 1 Y748 GHHPGADYPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9564 : Phospho-beta-Catenin (Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
19807 : Non-phospho (Active) beta-Catenin (Ser45) (D2U8Y) XP(R) Rabbit mAb
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
  human

 
K19‑ac MAMEPDRkAAVsHWQ
K19‑ub MAMEPDRkAAVsHWQ
S23‑p PDRkAAVsHWQQQsy
S23 PDRkAAVSHWQQQsy
S29‑p VsHWQQQsyLDsGIH
Y30‑p sHWQQQsyLDsGIHs
S33‑p QQQsyLDsGIHsGAT
S37‑p yLDsGIHsGATtTAP
T41‑p GIHsGATtTAPsLsG
S45‑p GATtTAPsLsGkGNP
S47‑p TtTAPsLsGkGNPEE
K49‑ac TAPsLsGkGNPEEED
K49‑ub TAPsLsGkGNPEEED
Y64‑p VDTSQVLyEWEQGFS
S73‑p WEQGFSQsFTQEQVA
Y86‑p VADIDGQyAMTRAQR
T102‑p RAAMFPEtLDEGMQI
T112‑p EGMQIPStQFdAAHP
D115‑ca QIPStQFdAAHPtNV
T120‑p QFdAAHPtNVQRLAE
K133‑ub AEPSQMLkHAVVNLI
Y142‑p AVVNLINyQDDAELA
K158‑ub RAIPELTkLLNDEDQ
K170‑ub EDQVVVNkAAVMVHQ
S179‑p AVMVHQLskKEASRH
K180‑ub VMVHQLskKEASRHA
S191‑p SRHAIMRsPQMVsAI
S196‑p MRsPQMVsAIVRTMQ
S222‑p AGTLHNLsHHREGLL
K233‑ub EGLLAIFkSGGIPAL
S246‑p ALVKMLGsPVDSVLF
Y331‑p LVNIMRTytyEkLLW
T332‑p VNIMRTytyEkLLWT
Y333‑p NIMRTytyEkLLWTT
K335‑ub MRTytyEkLLWTTSR
K345‑ac WTTSRVLkVLSVCSS
K345‑ub WTTSRVLkVLSVCSS
K354‑ac LSVCSSNkPAIVEAG
K354‑ub LSVCSSNkPAIVEAG
T393‑p RNLSDAAtkQEGMEG
K394‑ub NLSDAAtkQEGMEGL
K435‑ac TCNNYKNkMMVCQVG
K435‑ub TCNNYKNkMMVCQVG
T472‑p ICALRHLtsRHQEAE
S473‑p CALRHLtsRHQEAEM
Y489‑p QNAVRLHyGLPVVVK
K508‑ub PSHWPLIkAtVGLIR
T510‑p HWPLIkAtVGLIRNL
T547‑p LVRAHQDtQRRtsMG
T551‑p HQDtQRRtsMGGtQQ
S552‑p QDtQRRtsMGGtQQQ
T556‑p RRtsMGGtQQQFVEG
T574‑p EEIVEGCtGALHILA
S605‑p LFVQLLYsPIENIQR
K625‑ub LCELAQDkEAAEAIE
S646‑p PLTELLHsRNEGVAt
T653‑p sRNEGVAtyAAAVLF
Y654‑p RNEGVAtyAAAVLFR
Y670‑p SEDKPQDykKRLsVE
K671‑ub EDKPQDykKRLsVEL
S675‑p QDykKRLsVELtsSL
T679‑p KRLsVELtsSLFRTE
S680‑p RLsVELtsSLFRTEP
S681 LsVELtsSLFRTEPM
T685 LtsSLFRTEPMAWNE
T693 EPMAWNETADLGLDI
S715‑p GYRQDDPsyRsFHsG
Y716‑p YRQDDPsyRsFHsGG
S718‑p QDDPsyRsFHsGGyG
S721‑p PsyRsFHsGGyGQDA
Y724‑p RsFHsGGyGQDALGM
Y748‑p GHHPGADyPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9564 : Phospho-beta-Catenin (Ser45) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
19807 : Non-phospho (Active) beta-Catenin (Ser45) (D2U8Y) XP(R) Rabbit mAb
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
  rat

 
K19 MAMEPDRKAAVSHWQ
K19 MAMEPDRKAAVSHWQ
S23 PDRKAAVSHWQQQSY
S23 PDRKAAVSHWQQQSY
S29 VSHWQQQSYLDsGIH
Y30 SHWQQQSYLDsGIHs
S33‑p QQQSYLDsGIHsGAT
S37‑p YLDsGIHsGATtTAP
T41‑p GIHsGATtTAPsLSG
S45‑p GATtTAPsLSGKGNP
S47 TtTAPsLSGKGNPEE
K49 TAPsLSGKGNPEEED
K49 TAPsLSGKGNPEEED
Y64 VDTSQVLYEWEQGFS
S73 WEQGFSQSFTQEQVA
Y86 VADIDGQYAMTRAQR
T102 RAAMFPETLDEGMQI
T112 EGMQIPSTQFDAAHP
D115 QIPSTQFDAAHPTNV
T120 QFDAAHPTNVQRLAE
K133 AEPSQMLKHAVVNLI
Y142‑p AVVNLINyQDDAELA
K158 RAIPELTKLLNDEDQ
K170 EDQVVVNKAAVMVHQ
S179 AVMVHQLSKKEASRH
K180 VMVHQLSKKEASRHA
S191‑p SRHAIMRsPQMVSAI
S196 MRsPQMVSAIVRTMQ
S222 AGTLHNLSHHREGLL
K233 EGLLAIFKSGGIPAL
S246 ALVKMLGSPVDSVLF
Y331 LVNIMRTYTYEKLLW
T332 VNIMRTYTYEKLLWT
Y333 NIMRTYTYEKLLWTT
K335 MRTYTYEKLLWTTSR
K345 WTTSRVLKVLSVCSS
K345 WTTSRVLKVLSVCSS
K354 LSVCSSNKPAIVEAG
K354 LSVCSSNKPAIVEAG
T393 RNLSDAATKQEGMEG
K394 NLSDAATKQEGMEGL
K435 TCNNYKNKMMVCQVG
K435 TCNNYKNKMMVCQVG
T472 ICALRHLTSRHQEAE
S473 CALRHLTSRHQEAEM
Y489‑p QNAVRLHyGLPVVVK
K508 PSHWPLIKATVGLIR
T510 HWPLIKATVGLIRNL
T547 LVRAHQDTQRRtsMG
T551‑p HQDTQRRtsMGGTQQ
S552‑p QDTQRRtsMGGTQQQ
T556 RRtsMGGTQQQFVEG
T574 EEIVEGCTGALHILA
S605 LFVQLLYSPIENIQR
K625 LCELAQDKEAAEAIE
S646 PLTELLHSRNEGVAT
T653 SRNEGVATyAAAVLF
Y654‑p RNEGVATyAAAVLFR
Y670 SEDKPQDYKKRLsVE
K671 EDKPQDYKKRLsVEL
S675‑p QDYKKRLsVELTSSL
T679 KRLsVELTSSLFRTE
S680 RLsVELTSSLFRTEP
S681 LsVELTSSLFRTEPM
T685 LTSSLFRTEPMAWNE
T693 EPMAWNETADLGLDI
S715 GYRQDDPSYRSFHSG
Y716 YRQDDPSYRSFHSGG
S718 QDDPSYRSFHSGGYG
S721 PSYRSFHSGGYGQDA
Y724 RSFHSGGYGQDALGM
Y748 GHHPGADYPVDGLPD
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
2009 : Phospho-beta-Catenin (Ser33/37) Antibody
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
4270 : Non-phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9561 : Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
13537 : Non-phospho (Active) beta-Catenin (Ser33/37/Thr41) (D13A1) Rabbit mAb (PE Conjugate)
9565 : Phospho-beta-Catenin (Thr41/Ser45) Antibody
19807 : Non-phospho (Active) beta-Catenin (Ser45) (D2U8Y) XP(R) Rabbit mAb
9030 : Acetyl-beta-Catenin (Lys49) (D7C2) Rabbit mAb
9534 : Acetyl-beta-Catenin (Lys49) Antibody
5651 : Phospho-beta-Catenin (Ser552) (D8E11) Rabbit mAb
9566 : Phospho-beta-Catenin (Ser552) Antibody
4176 : Phospho-beta-Catenin (Ser675) (D2F1) XP(TM) Rabbit mAb
9567 : Phospho-beta-Catenin (Ser675) Antibody
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