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Protein Page:
Ikaros (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ikaros a transcription factor of the ikaros C2H2-type zinc-finger protein family. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Deletions in Ikaros have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Seven alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 7p12.2
Cellular Component: centric heterochromatin; cytoplasm; nucleus; protein complex
Molecular Function: DNA binding; metal ion binding; poly-pyrimidine tract binding; protein binding; protein heterodimerization activity; transcription factor activity
Biological Process: B cell differentiation; cell cycle; chromatin modification; erythrocyte differentiation; establishment of protein localization; forebrain development; lymph node development; lymphocyte differentiation; mesoderm development; natural killer cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Peyer's patch development; positive regulation of B cell differentiation; positive regulation of multicellular organism growth; positive regulation of neutrophil differentiation; positive regulation of NK T cell differentiation; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcriptional preinitiation complex assembly; retinal bipolar neuron differentiation; T cell differentiation; thymus development; transcription, DNA-dependent
Reference #:  Q13422 (UniProtKB)
Alt. Names/Synonyms: CLL-associated antigen KW-6; DNA-binding protein Ikaros; hIk-1; Hs.54452; IK1; IKAROS; Ikaros (zinc finger protein); IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; IKZF1; LYF1; Lymphoid transcription factor LyF-1; PRO0758; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1
Gene Symbols: IKZF1
Molecular weight: 57,528 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ikaros

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, induced: S361‑p, S364‑p
transcription, induced: S361‑p, S364‑p
intracellular localization: S361‑p, S364‑p
molecular association, regulation: S361‑p, S364‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 S13 GQDMSQVSGKESPPV
1 0 T23 ESPPVSDTPDEGDEP
0 2 - gap
1 0 K58 RVVASNVKVEtQsDE
0 1 T61‑p ASNVKVEtQsDEENG
2 13 S63‑p NVKVEtQsDEENGRA
0 1 S88‑p DLRMLDAsGEkMNGs
0 1 K91‑ub MLDAsGEkMNGsHRD
0 1 S95‑p sGEkMNGsHRDQGSS
1 0 S101 GsHRDQGSSALsGVG
0 1 S105‑p DQGSSALsGVGGIRL
1 1 T140‑p MVHKRSHtGERPFQC
2 1 S168‑p LRHIKLHsGEKPFKC
1 1 S196 TGHLRTHSVGKPHKC
1 0 S214‑p GRSYKQRssLEEHKE
1 0 S215‑p RSYKQRssLEEHKER
1 0 K241 GTLYPVIKEETNHSE
0 1 S258‑p EDLCKIGsERsLVLD
0 3 S261‑p CKIGsERsLVLDRLA
0 26 S269‑p LVLDRLAsNVAkRKS
0 1 K273‑ub RLAsNVAkRKSSMPQ
0 1 K281‑ub RKSSMPQkFLGDkGL
0 1 K286‑ub PQkFLGDkGLsDtPy
0 3 S289‑p FLGDkGLsDtPyDss
0 2 T291‑p GDkGLsDtPyDssAs
0 3 Y293‑p kGLsDtPyDssAsyE
1 5 S295‑p LsDtPyDssAsyEkE
0 2 S296‑p sDtPyDssAsyEkEN
0 3 S298‑p tPyDssAsyEkENEM
0 1 Y299‑p PyDssAsyEkENEMM
0 1 K301‑ub DssAsyEkENEMMKS
0 3 Y321‑p AINNAINyLGAESLR
0 1 S326 INyLGAESLRPLVQt
0 4 T333‑p SLRPLVQtPPGGSEV
0 1 G337 LVQtPPGGSEVVPVI
0 1 S338 VQtPPGGSEVVPVIs
0 3 S345‑p SEVVPVIsPMyQLHK
0 1 P346 EVVPVIsPMyQLHKP
0 7 Y348‑p VPVIsPMyQLHKPLA
0 1 A355 yQLHKPLAEGtPRsN
0 1 T358‑p HKPLAEGtPRsNHsA
1 4 S361‑p LAEGtPRsNHsAQDs
1 6 S364‑p GtPRsNHsAQDsAVE
0 2 S368‑p sNHsAQDsAVENLLL
0 3 S377‑p VENLLLLsKAkLVPS
0 1 K380‑ub LLLLsKAkLVPSERE
1 5 S389‑p VPSEREAsPsNsCQD
2 3 S391‑p SEREAsPsNsCQDst
2 4 S393‑p REAsPsNsCQDstDT
1 2 S397‑p PsNsCQDstDTEsNN
1 5 T398‑p sNsCQDstDTEsNNE
0 1 T400 sCQDstDTEsNNEEQ
0 5 S402‑p QDstDTEsNNEEQRs
0 3 S409‑p sNNEEQRsGLIyLtN
0 92 Y413‑p EQRsGLIyLtNHIAP
0 3 T415‑p RsGLIyLtNHIAPHA
0 1 S427‑p PHARNGLsLkEEHRA
0 2 K429‑ub ARNGLsLkEEHRAyD
0 20 Y435‑p LkEEHRAyDLLRAAs
0 38 S442‑p yDLLRAAsENsQDAL
0 27 S445‑p LRAAsENsQDALRVV
0 1 K460‑ub STSGEQMkVYKCEHC
  Ikaros iso2  
S13 GQDMSQVSGKESPPV
T23 ESPPVSDTPDEGDEP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S81 LRHIKLHSGEKPFKC
S109 TGHLRTHSVGKPHKC
S127 GRSYKQRSSLEEHKE
S128 RSYKQRSSLEEHKER
K154 GTLYPVIKEETNHSE
S171 EDLCKIGSERSLVLD
S174 CKIGSERSLVLDRLA
S182 LVLDRLASNVAKRKS
K186 RLASNVAKRKSSMPQ
K194 RKSSMPQKFLGDKGL
K199 PQKFLGDKGLSDTPY
S202 FLGDKGLSDTPYDSS
T204 GDKGLSDTPYDSSAS
Y206 KGLSDTPYDSSASYE
S208 LSDTPYDSSASYEKE
S209 SDTPYDSSASYEKEN
S211 TPYDSSASYEKENEM
Y212 PYDSSASYEKENEMM
K214 DSSASYEKENEMMKS
Y234 AINNAINYLGAESLR
S239 INYLGAESLRPLVQT
T246 SLRPLVQTPPGGSEV
G250 LVQTPPGGSEVVPVI
S251 VQTPPGGSEVVPVIS
S258 SEVVPVISPMYQLHK
P259 EVVPVISPMYQLHKP
Y261 VPVISPMYQLHKPLA
A268 YQLHKPLAEGTPRSN
T271 HKPLAEGTPRSNHSA
S274 LAEGTPRSNHSAQDS
S277 GTPRSNHSAQDSAVE
S281 SNHSAQDSAVENLLL
S290 VENLLLLSKAKLVPS
K293 LLLLSKAKLVPSERE
S302 VPSEREASPSNSCQD
S304 SEREASPSNSCQDST
S306 REASPSNSCQDSTDT
S310 PSNSCQDSTDTESNN
T311 SNSCQDSTDTESNNE
T313 SCQDSTDTESNNEEQ
S315 QDSTDTESNNEEQRS
S322 SNNEEQRSGLIYLTN
Y326 EQRSGLIYLTNHIAP
T328 RSGLIYLTNHIAPHA
S340 PHARNGLSLKEEHRA
K342 ARNGLSLKEEHRAYD
Y348 LKEEHRAYDLLRAAS
S355 YDLLRAASENSQDAL
S358 LRAASENSQDALRVV
K373 STSGEQMKVYKCEHC
  Ikaros iso3  
S13 GQDMSQVSGKESPPV
T23 ESPPVSDTPDEGDEP
- gap
K58 RVVASNVKVETQSDE
T61 ASNVKVETQSDEENG
S63 NVKVETQSDEENGRA
S88 DLRMLDASGEKMNGS
K91 MLDASGEKMNGSHRD
S95 SGEKMNGSHRDQGSS
S101 GSHRDQGSSALSGVG
S105 DQGSSALSGVGGIRL
T140 MVHKRSHTGERPFQC
S168 LRHIKLHSGEKPFKC
S196 TGHLRTHSGDKGLSD
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K199 LRTHSGDKGLSDTPY
S202 HSGDKGLSDTPYDSS
T204 GDKGLSDTPYDSSAS
Y206 KGLSDTPYDSSASYE
S208 LSDTPYDSSASYEKE
S209 SDTPYDSSASYEKEN
S211 TPYDSSASYEKENEM
Y212 PYDSSASYEKENEMM
K214 DSSASYEKENEMMKS
Y234 AINNAINYLGAESLR
S239 INYLGAESLRPLVQT
T246 SLRPLVQTPPGGSEV
G250 LVQTPPGGSEVVPVI
S251 VQTPPGGSEVVPVIS
S258 SEVVPVISPMYQLHK
P259 EVVPVISPMYQLHKP
Y261 VPVISPMYQLHKPLA
A268 YQLHKPLAEGTPRSN
T271 HKPLAEGTPRSNHSA
S274 LAEGTPRSNHSAQDS
S277 GTPRSNHSAQDSAVE
S281 SNHSAQDSAVENLLL
S290 VENLLLLSKAKLVPS
K293 LLLLSKAKLVPSERE
S302 VPSEREASPSNSCQD
S304 SEREASPSNSCQDST
S306 REASPSNSCQDSTDT
S310 PSNSCQDSTDTESNN
T311 SNSCQDSTDTESNNE
T313 SCQDSTDTESNNEEQ
S315 QDSTDTESNNEEQRS
S322 SNNEEQRSGLIYLTN
Y326 EQRSGLIYLTNHIAP
T328 RSGLIYLTNHIAPHA
S340 PHARNGLSLKEEHRA
K342 ARNGLSLKEEHRAYD
Y348 LKEEHRAYDLLRAAS
S355 YDLLRAASENSQDAL
S358 LRAASENSQDALRVV
K373 STSGEQMKVYKCEHC
  Ikaros iso7  
S13 GQDMSQVSGKESPPV
T23 ESPPVSDTPDEGDEP
- gap
K58 RVVASNVKVETQSDE
T61 ASNVKVETQSDEENG
S63 NVKVETQSDEENGRA
S88 DLRMLDASGEKMNGS
K91 MLDASGEKMNGSHRD
S95 SGEKMNGSHRDQGSS
S101 GSHRDQGSSALSGVG
S105 DQGSSALSGVGGIRL
T140 MVHKRSHTGERPFQC
S168 LRHIKLHSGEKPFKC
S196‑p TGHLRTHsVIKEETN
- gap
- gap
K199 LRTHsVIKEETNHSE
S216 EDLCKIGSERSLVLD
S219 CKIGSERSLVLDRLA
S227 LVLDRLASNVAKRKS
K231 RLASNVAKRKSSMPQ
K239 RKSSMPQKFLGDKGL
K244 PQKFLGDKGLSDTPY
S247 FLGDKGLSDTPYDSS
T249 GDKGLSDTPYDSSAS
Y251 KGLSDTPYDSSASYE
S253 LSDTPYDSSASYEKE
S254 SDTPYDSSASYEKEN
S256 TPYDSSASYEKENEM
Y257 PYDSSASYEKENEMM
K259 DSSASYEKENEMMKS
Y279 AINNAINYLGAESLR
S284 INYLGAESLRPLVQT
T291 SLRPLVQTPPGGSEV
G295 LVQTPPGGSEVVPVI
S296 VQTPPGGSEVVPVIS
S303 SEVVPVISPMYQLHK
P304 EVVPVISPMYQLHKP
Y306 VPVISPMYQLHKPLA
A313 YQLHKPLAEGTPRSN
T316 HKPLAEGTPRSNHSA
S319 LAEGTPRSNHSAQDS
S322 GTPRSNHSAQDSAVE
S326 SNHSAQDSAVENLLL
S335 VENLLLLSKAKLVPS
K338 LLLLSKAKLVPSERE
S347 VPSEREASPSNSCQD
S349 SEREASPSNSCQDST
S351 REASPSNSCQDSTDT
S355 PSNSCQDSTDTESNN
T356 SNSCQDSTDTESNNE
T358 SCQDSTDTESNNEEQ
S360 QDSTDTESNNEEQRS
S367 SNNEEQRSGLIYLTN
Y371 EQRSGLIYLTNHIAP
T373 RSGLIYLTNHIAPHA
S385 PHARNGLSLKEEHRA
K387 ARNGLSLKEEHRAYD
Y393 LKEEHRAYDLLRAAS
S400 YDLLRAASENSQDAL
S403 LRAASENSQDALRVV
K418 STSGEQMKVYKCEHC
  mouse

► Hide Isoforms
 
S13‑p GQDMSQVsGKESPPV
T23‑p ESPPVSDtPDEGDEP
- gap
K58‑sm RGMGSNVkVETQsDE
T61 GSNVkVETQsDEENG
S63‑p NVkVETQsDEENGRA
S88 DLRMLDASGEKMNGS
K91 MLDASGEKMNGSHRD
S95 SGEKMNGSHRDQGsS
S101‑p GSHRDQGsSALSGVG
S105 DQGsSALSGVGGIRL
T140‑p MVHKRSHtERPFQCN
S167‑p LRHIKLHsGEKPFKC
S195‑p TGHLRTHsVGKPHKC
S213‑p GRSYKQRssLEEHKE
S214‑p RSYKQRssLEEHKER
K239‑sm PGVCPVIkEETNHNE
A256 EDLCKIGAERSLVLD
S259 CKIGAERSLVLDRLA
S267‑p LVLDRLAsNVAKRKS
K271 RLAsNVAKRKSSMPQ
K279 RKSSMPQKFLGDKCL
K284 PQKFLGDKCLSDMPY
S287 FLGDKCLSDMPYDsA
M289 GDKCLSDMPYDsANY
Y291 KCLSDMPYDsANYEK
S293‑p LSDMPYDsANYEKED
- gap
N295 DMPYDsANYEKEDMM
Y296 MPYDsANYEKEDMMT
K298 YDsANYEKEDMMTSH
Y317‑p AINNAINyLGAEsLR
S322‑p INyLGAEsLRPLVQt
T329‑p sLRPLVQtPPGssEV
S333‑p LVQtPPGssEVVPVI
S334‑p VQtPPGssEVVPVIs
S341‑p sEVVPVIssMyQLHK
S342‑p EVVPVIssMyQLHKP
Y344‑p VPVIssMyQLHKPPs
S351‑p yQLHKPPsDGPPRsN
P354 HKPPsDGPPRsNHsA
S357‑p PsDGPPRsNHsAQDA
S360‑p GPPRsNHsAQDAVDN
- gap
S372‑p VDNLLLLsKAKSVSS
K375 LLLLsKAKSVSSERE
S384‑p VSSEREAsPsNsCQD
S386‑p SEREAsPsNsCQDst
S388‑p REAsPsNsCQDstDt
S392‑p PsNsCQDstDtEsNA
T393‑p sNsCQDstDtEsNAE
T395‑p sCQDstDtEsNAEEQ
S397‑p QDstDtEsNAEEQRs
S404‑p sNAEEQRsGLIYLTN
Y408 EQRsGLIYLTNHINP
T410 RsGLIYLTNHINPHA
A422 PHARNGLALKEEQRA
K424 ARNGLALKEEQRAYE
Y430 LKEEQRAYEVLRAAs
S437‑p YEVLRAAsENsQDAF
S440‑p LRAAsENsQDAFRVV
K455 STSGEQLKVYKCEHC
  Ikaros iso9  
S13 GQDMSQVSGKESPPV
T23 ESPPVSDTPDEGDEP
S73‑p AIIPKSFsPSNVKVE
K78 SFsPSNVKVETQsDE
T81 PSNVKVETQsDEENG
S83‑p NVKVETQsDEENGRA
S108 DLRMLDASGEKMNGS
K111 MLDASGEKMNGSHRD
S115 SGEKMNGSHRDQGSS
S121 GSHRDQGSSALSGVG
S125 DQGSSALSGVGGIRL
T160 MVHKRSHTGERPFQC
S188 LRHIKLHSGEKPFKC
S216 TGHLRTHSVGKPHKC
S234 GRSYKQRSSLEEHKE
S235 RSYKQRSSLEEHKER
K260 PGMYPVIKEETNHNE
A277 EDLCKIGAERSLVLD
S280 CKIGAERSLVLDRLA
S288 LVLDRLASNVAKRKS
K292 RLASNVAKRKSSMPQ
K300 RKSSMPQKFLGDKCL
K305 PQKFLGDKCLSDMPY
S308 FLGDKCLSDMPYDSA
M310 GDKCLSDMPYDSANY
Y312 KCLSDMPYDSANYEK
S314 LSDMPYDSANYEKED
- gap
N316 DMPYDSANYEKEDMM
Y317 MPYDSANYEKEDMMT
K319 YDSANYEKEDMMTSH
Y338 AINNAINYLGAESLR
S343 INYLGAESLRPLVQT
T350 SLRPLVQTPPGSSEV
S354 LVQTPPGSSEVVPVI
S355 VQTPPGSSEVVPVIS
S362 SEVVPVISSMYQLHK
S363 EVVPVISSMYQLHKP
Y365 VPVISSMYQLHKPPS
S372 YQLHKPPSDGPPRSN
P375 HKPPSDGPPRSNHSA
S378 PSDGPPRSNHSAQDA
S381 GPPRSNHSAQDAVDN
- gap
S393 VDNLLLLSKAKSVSS
K396 LLLLSKAKSVSSERE
S405 VSSEREASPSNSCQD
S407 SEREASPSNSCQDST
S409 REASPSNSCQDSTDT
S413 PSNSCQDSTDTESNA
T414 SNSCQDSTDTESNAE
T416 SCQDSTDTESNAEEQ
S418 QDSTDTESNAEEQRS
S425 SNAEEQRSGLIYLTN
Y429 EQRSGLIYLTNHINP
T431 RSGLIYLTNHINPHA
A443 PHARNGLALKEEQRA
K445 ARNGLALKEEQRAYE
Y451 LKEEQRAYEVLRAAS
S458 YEVLRAASENSQDAF
S461 LRAASENSQDAFRVV
K476 STSGEQLKVYKCEHC
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