Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. Homodimer. Heterodimer with RARA; required for ligand- dependent retinoic acid receptor transcriptional activity. Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity. Also heterodimerizes with PPARG. Interacts with NCOA3 and NCOA6 coactivators. Interacts with FAM120B. Interacts with PELP1, SENP6, SFPQ, DNTTIP2 and RNF8. Interacts (via the DNA binding domain) with HCV core protein; the interaction enhances the transcriptional activities of the RXRA/RARA and the RXRA/PPARA heterodimers. Interacts with PRMT2. Interacts with ASXL1 and NCOA1. Highly expressed in liver, also found in lung, kidney and heart. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; Motility/polarity/chemotaxis; DNA-binding
Molecular Function: chromatin DNA binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; protein binding; protein complex binding; protein domain specific binding; protein heterodimerization activity; retinoic acid receptor activity; retinoic acid receptor binding; retinoid-X receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; transcription coactivator activity; transcription factor activity; vitamin D receptor binding; zinc ion binding
Biological Process: aging; axon regeneration; bile acid and bile salt transport; bile acid metabolic process; camera-type eye development; cellular lipid metabolic process; cellular response to insulin stimulus; cholesterol metabolic process; embryo implantation; gene expression; in utero embryonic development; inflammatory response; liver development; maternal placenta development; midgut development; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translational initiation by iron; protein homotetramerization; regulation of myelination; response to ethanol; response to glucocorticoid stimulus; response to retinoic acid; response to selenium ion; response to vitamin A; response to vitamin D; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter; ventricular cardiac muscle cell differentiation; ventricular cardiac muscle morphogenesis; virus-host interaction; vitamin metabolic process
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.