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Protein Page:
Btk (human)

Overview
Btk a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of Human Ortholog: Xq21.33-q22
Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; intracellular membrane-bound organelle; lipid raft; nucleus; plasma membrane
Molecular Function: ATP binding; identical protein binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein-tyrosine kinase activity; receptor binding
Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium-mediated signaling; innate immune response; mesoderm development; MyD88-dependent toll-like receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of B cell differentiation; protein amino acid phosphorylation; regulation of B cell apoptosis; regulation of B cell cytokine production; regulation of cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Agammaglobulinemia, X-linked; Isolated Growth Hormone Deficiency, Type Iii
Reference #:  Q06187 (UniProtKB)
Alt. Names/Synonyms: Agammaglobulinaemia tyrosine kinase; AGMX1; AT; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; MGC126261; MGC126262; PSCTK1; Tyrosine-protein kinase BTK; XLA
Gene Symbols: BTK
Molecular weight: 76,281 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Btk

Protein Structure Not Found.
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