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Protein Page:
CD34 (mouse)

CD34 Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1 H6|1 98.38 cM
Cellular Component: apical plasma membrane; basal plasma membrane; cell surface; cytoplasm; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular bridge; lysosome; membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: carbohydrate binding; sulfate binding; transcription factor binding
Biological Process: cell-cell adhesion; cell-matrix adhesion; endothelial cell proliferation; hemopoiesis; leukocyte migration; negative regulation of blood coagulation; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of interleukin-10 production; positive regulation of odontogenesis; regulation of blood pressure; tissue homeostasis
Reference #:  Q64314 (UniProtKB)
Alt. Names/Synonyms: AU040960; Cd34; CD34 antigen; cluster designation 34; Hematopoietic progenitor cell antigen CD34
Gene Symbols: Cd34
Molecular weight: 40,983 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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