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Protein Page:
DICER1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DICER1 a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Helicase; RNA processing; Ribonuclease; RNA-binding; EC 3.1.26.3
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: deoxyribonuclease I activity; double-stranded RNA binding; endoribonuclease activity; protein binding; protein domain specific binding; ribonuclease III activity; siRNA binding
Biological Process: DNA fragmentation during apoptosis; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; negative regulation of transcription from RNA polymerase II promoter; nerve development; neurite morphogenesis; positive regulation of myelination; positive regulation of Schwann cell differentiation; pre-microRNA processing; RNA interference, conversion of ds siRNA to ss siRNA; RNA interference, production of siRNA; RNA interference, siRNA loading onto RISC; RNA interference, targeting of mRNA for destruction; RNA-mediated gene silencing
Disease: Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Pleuropulmonary Blastoma; Rhabdomyosarcoma, Embryonal, 2
Reference #:  Q9UPY3 (UniProtKB)
Alt. Names/Synonyms: DCR1; DICER; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; DICER1; Dicer1, Dcr-1 homolog; Endoribonuclease Dicer; Helicase MOI; Helicase with RNase motif; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928
Gene Symbols: DICER1
Molecular weight: 218,682 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DICER1

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S82‑p VLLTKELsYQIRGDF
0 1 T238‑p KSNAETAtDLVVLDR
0 11 S397‑p YERQQFEsVEWYNNR
0 2 S413‑p QDNYVSWsDsEDDDE
0 2 S415‑p NYVSWsDsEDDDEDE
0 1 Y452‑p IIFVERRyTAVVLNR
0 1 Y546 LPTEYRSYVQSKGRA
0 2 S643‑p RYCARLPsDPFTHLA
0 2 K652‑ub PFTHLAPkCRTRELP
0 5 Y664‑p ELPDGTFySTLyLPI
0 2 Y668‑p GTFySTLyLPINSPL
0 1 Y819‑p QIPHFPVytRSGEVT
0 1 T820‑p IPHFPVytRSGEVTI
0 1 S828‑p RSGEVTIsIELKKSG
0 1 Y946 FDQPHRFYVADVYTD
0 1 Y951 RFYVADVYTDLTPLS
0 1 S962‑p TPLSKFPsPEYEtFA
0 1 T967‑p FPsPEYEtFAEYYKT
0 1 T974 tFAEYYKTKYNLDLT
0 1 Y976 AEYYKTKYNLDLTNL
0 1 T981 TKYNLDLTNLNQPLL
0 1 T993 PLLDVDHTSSRLNLL
0 1 S994 LLDVDHTSSRLNLLT
0 1 S995 LDVDHTSSRLNLLTP
0 5 S1016‑p GKALPLSsAEKRKAK
0 1 Y1091‑p SLPADFRyPNLDFGW
0 2 Y1121‑p SSAENDNyCKHSTIV
0 3 S1142‑p QGANRTSsLENHDQM
0 6 S1160‑p CRTLLSEsPGKLHVE
0 8 Y1204‑p CQGNQLNyYKQEIPV
0 1 S1252‑p GNANKSTsDGsPVMA
0 1 S1255‑p NKSTsDGsPVMAVMP
0 2 S1280‑p GRMDSEQsPSIGYSS
0 1 T1329‑p FLKHAITtyLFCTYP
0 5 Y1330‑p LKHAITtyLFCTYPD
0 1 K1391‑ac GYVVNQDkSNTDKWE
0 179 Y1438‑p APKEEADyEDDFLEy
0 119 Y1445‑p yEDDFLEyDQEHIRF
0 1 S1460‑p IDNMLMGsGAFVKKI
0 1 K1466 GsGAFVKKIsLsPFS
0 6 S1468‑p GAFVKKIsLsPFSTT
0 13 S1470‑p FVKKIsLsPFSTTDS
0 9 Y1479‑p FSTTDSAyEWKMPKK
0 1 S1612‑p PTRENFNsQQKNLSV
0 1 S1628 CAAASVASSRSSVLK
0 1 S1814 AMGDIFESLAGAIYM
0 1 Y1820 ESLAGAIYMDSGMSL
0 1 S1823 AGAIYMDSGMSLETV
0 3 S1852‑p FSANVPRsPVRELLE
0 2 S1868‑p EPETAKFsPAERTYD
0 2 S1922‑p NQPQVPNs_______
  DICER1 iso3  
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Y19 ILAENDNYCKHSTIV
S40 QGANRTSSLENHDQM
S58 CRTLLSESPGKLHVE
Y102 CQGNQLNYYKQEIPV
S150 GNANKSTSDGSPVMA
S153 NKSTSDGSPVMAVMP
S178 GRMDSEQSPSIGYSS
T227 FLKHAITTYLFCTYP
Y228 LKHAITTYLFCTYPD
K289 GYVVNQDKSNTDKWE
Y336 APKEEADYEDDFLEY
Y343 YEDDFLEYDQEHIRF
S358 IDNMLMGSGAFVKKI
K364 GSGAFVKKISLSPFS
S366 GAFVKKISLSPFSTT
S368 FVKKISLSPFSTTDS
Y377 FSTTDSAYEWKMPKK
S510 PTRENFNSQQKNLSV
S526 CAAASVASSRSSVLK
S712 AMGDIFESLAGAIYM
Y718 ESLAGAIYMDSGMSL
S721 AGAIYMDSGMSLETV
S750 FSANVPRSPVRELLE
S766 EPETAKFSPAERTYD
S820 NQPQVPNS_______
  mouse

 
A82 VLLTKELAHQIRGDL
T238 RSDAETATDLVVLDR
S397 YERQQFESVEWYNNR
S413 QDNYVSWSDSEDDDD
S415 NYVSWSDSEDDDDDE
Y452 IIFVERRYTAVVLNR
Y546 LPTEYRSYVQSKGRA
S643‑p RYCARLPsDPFTHLA
K652‑ub PFTHLAPkCRTRELP
Y664 ELPDGTFYSTLYLPI
Y668 GTFYSTLYLPINSPL
Y819 QIPHFPVYTRSGEVT
T820 IPHFPVYTRSGEVTI
S828 RSGEVTISIELKKSG
Y946 FDQPHRFYVADVYTD
Y951 RFYVADVYTDLTPLS
S962 TPLSKFPSPEYETFA
T967 FPSPEYETFAEYYKT
T974 TFAEYYKTKYNLDLT
Y976 AEYYKTKYNLDLTNL
T981 TKYNLDLTNLNQPLL
T993 PLLDVDHTSSRLNLL
S994 LLDVDHTSSRLNLLT
S995 LDVDHTSSRLNLLTP
S1016 GKALPLSSAEKRKAK
Y1091 SLPVDFRYPNLDFGW
Y1121 SLAESDNYCKHSTTV
S1142 HQGATRPSLENHDQM
S1160 CKRLPAESPAKLQSE
Y1204 CQGNQLNYFKQEIPV
S1252 GNANTSTSDGSPAVS
S1255 NTSTSDGSPAVSTMP
S1280 DRMDSEQSPSVGYSS
T1329 FLKHAITTYLFCTYP
Y1330 LKHAITTYLFCTYPD
K1391 GYVVNQDKSNSEKWE
D1434 APKEEAEDEDDFLEY
Y1441 DEDDFLEYDQEHIQF
S1456 IDSMLMGSGAFVRkI
K1462‑ub GSGAFVRkIsLsPFS
S1464‑p GAFVRkIsLsPFSAS
S1466‑p FVRkIsLsPFSASDS
Y1475 FSASDSAYEWKMPKK
S1608 PAQENGSSQQKSLSG
G1622 GSCAAPVGPRSSAGK
S1808‑p AMGDIFEsLAGAIyM
Y1814‑p EsLAGAIyMDsGMSL
S1817‑p AGAIyMDsGMSLEVV
S1846‑p FSANVPRsPVRELLE
S1862 EPETAKFSPAERTYD
S1916‑p NQPQVPNs_______
  rat

 
A82 VLLTKELAHQIRGDL
T238 KSGAETATDLVVLDR
S397 YERQQFESVEWYNNR
S413 QDNYVSWSDSEDDDD
S415 NYVSWSDSEDDDDDE
Y452 IIFVERRYTAVVLNR
Y546‑p LPTEYRSyVQSKGRA
S643 RYCARLPSDPFTHLA
K652 PFTHLAPKCRTRELP
Y664 ELPDGTFYSTLYLPI
Y668 GTFYSTLYLPINSPL
Y819 QIPHFPVYTRSGEVT
T820 IPHFPVYTRSGEVTI
S828 RSGEVTISIELKKSG
Y946‑p FDQPHRFyVADVyTD
Y951‑p RFyVADVyTDLTPLS
S962 TPLSKFPSPEYETFA
T967 FPSPEYETFAEYYKt
T974‑p TFAEYYKtKyNLDLt
Y976‑p AEYYKtKyNLDLtNL
T981‑p tKyNLDLtNLNQPLL
T993‑p PLLDVDHtssRLNLL
S994‑p LLDVDHtssRLNLLT
S995‑p LDVDHtssRLNLLTP
S1016 GKALPLSSAEKRKAK
Y1091 SLPADFRYPNLDFGW
Y1121 SLAESDNYCKHSTTV
S1142 HQGATRPSLENHDQM
S1160 CKRLPAESPAKLQSE
Y1204 CQGNQLTYFKQEIPV
S1252 GNANTSTSDGSPAGS
S1255 NTSTSDGSPAGSPRP
S1280 GRTDSEQSPSVGHSS
T1329 FLKHAITTYLFCTYP
Y1330 LKHAITTYLFCTYPD
K1391 GYVVNQDKSNSEKWE
Y1436 APKEEAEYEDDLLEY
Y1443 YEDDLLEYDQEHIQF
S1458 IDSMLMGSGAFVKKI
K1464 GSGAFVKKIPLSPFS
P1466 GAFVKKIPLSPFSTS
S1468 FVKKIPLSPFSTSDS
Y1477 FSTSDSAYEWKMPKK
S1610 PAQENSSSQQKSPSG
S1624‑p GSCAAAVsPRSSAGK
S1810 AMGDIFESLAGAIYM
Y1816 ESLAGAIYMDSGMSL
S1819 AGAIYMDSGMSLEVV
S1848 FSANVPRSPVRELLE
S1864 EPETAKFSPAERTYD
S1918 NQPLVPNS_______
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