a protein of the band 7 family. This family includes the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. A repressor of estrogen receptor (ER) activity. Reverses steroid receptor coactivator 1 enhancement of ER activity. May play a role in determining the sensitivity of estrogen target cells to antiestrogen and estrogen therapy. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Molecular Function: amide binding; protein binding; protein C-terminus binding; protein N-terminus binding
Biological Process: mitochondrial calcium ion transport; mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of exit from mitosis; positive regulation of transcription factor activity; protein import into nucleus, translocation; protein stabilization; regulation of complement activation; sister chromatid cohesion