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Protein Page:
PSMB7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMB7 a proteasomal protein of the T1B peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. Not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). Note: This description may include information from UniProtKB.
Protein type: EC 3.4.25.1; Proteasome complex; Protease
Chromosomal Location of Human Ortholog: 9q34.11-q34.12
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex
Molecular Function: protein binding; threonine endopeptidase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; viral reproduction; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  Q99436 (UniProtKB)
Gene Symbols: PSMB7
Molecular weight: 29,965 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PSMB7

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S5‑p ___MAAVsVyAPPVG
0 1 Y7‑p _MAAVsVyAPPVGGF
0 20 K31‑ub VLEADFAkRGYKLPK
0 1 K41‑ub YKLPKVRkTGtTIAG
0 1 T44‑p PKVRkTGtTIAGVVy
0 1 Y51‑p tTIAGVVykDGIVLG
0 2 K52‑ub TIAGVVykDGIVLGA
0 13 K72‑ub EGMVVADkNCSKIHF
0 1 T121 GRLPRVVTANRMLkQ
0 7 K127‑ub VTANRMLkQMLFRYQ
0 3 Y154‑p DVTGPHLySIYPHGS
0 1 K195 DMEEEEAKNLVSEAI
0 2 K195 DMEEEEAKNLVSEAI
0 1 N196 MEEEEAKNLVSEAIA
0 1 N224 DLCVISKNkLDFLRP
0 4 K225‑ub LCVISKNkLDFLRPY
0 1 T233 LDFLRPYTVPNkKGT
0 3 K237 RPYTVPNKKGTRLGR
0 2 K237‑ub RPYTVPNkKGTRLGR
0 7 K249‑ub LGRYRCEkGTTAVLT
  mouse

 
S5 ___MAAVSVFQPPVG
F7 _MAAVSVFQPPVGGF
K31 VLEADFAKKGFKLPK
K41 FKLPKARKTGTTIAG
T44 PKARKTGTTIAGVVY
Y51 TTIAGVVYkDGIVLG
K52‑ub TIAGVVYkDGIVLGA
K72‑ub EGMVVADkNCSKIHF
T121‑p GRLPRVVtANRMLKQ
K127 VtANRMLKQMLFRYQ
Y154‑p DVTGPHLySIYPHGS
K195‑ac DMEEEEAkkLVSEAI
K195‑ub DMEEEEAkkLVSEAI
K196‑ub MEEEEAkkLVSEAIA
S224‑p DLCVISKskLDFLRP
K225‑ub LCVISKskLDFLRPF
S233‑p LDFLRPFsVPNkKGT
K237‑ac RPFsVPNkKGTRLGR
K237‑ub RPFsVPNkKGTRLGR
K249 LGRYRCEKGTTAVLT
  rat

 
S5 ___MAAVSVFQAPVG
F7 _MAAVSVFQAPVGGF
K31 VLEADFAKKGFKLPK
K41 FKLPKARKTGTTIAG
T44 PKARKTGTTIAGVVY
Y51 TTIAGVVYKDGIVLG
K52 TIAGVVYKDGIVLGA
K72 EGMVVADKNCSKIHF
T121 GRLPRVVTANRMLKQ
K127 VTANRMLKQMLFRYQ
Y154 DVTGPHLYSIYPHGS
K195 DMEEEEAKKLVSEAI
K195 DMEEEEAKKLVSEAI
K196 MEEEEAKKLVSEAIA
S224 DLCVISKSKLDFLRP
K225 LCVISKSKLDFLRPY
S233 LDFLRPYSVPNkKGT
K237‑ac RPYSVPNkKGTRFGR
K237 RPYSVPNKKGTRFGR
K249 FGRYRCEKGTTAVLT
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