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Protein Page:
GCN5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GCN5 an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 2.3.1.48
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: extracellular space; nuclear chromatin; nucleoplasm
Molecular Function: chromatin binding; H3 histone acetyltransferase activity; histone acetyltransferase activity; histone deacetylase binding; protein binding; protein phosphatase binding; transcription coactivator activity; transcription factor binding
Biological Process: cardiac muscle cell differentiation; cell proliferation; chromatin remodeling; histone deubiquitination; in utero embryonic development; intracellular distribution of mitochondria; metencephalon development; midbrain development; multicellular organism growth; neural tube closure; positive regulation of cell projection organization and biogenesis; positive regulation of gene expression, epigenetic; positive regulation of histone acetylation; regulation of protein stability; regulation of transcription from RNA polymerase II promoter; response to nutrient levels; response to organic cyclic substance; somitogenesis; telencephalon development; transcription from RNA polymerase II promoter; viral reproduction
Reference #:  Q92830 (UniProtKB)
Gene Symbols: KAT2A
Molecular weight: 93,926 Da
Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GCN5

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T272‑p LNYWKLEtPAQFRQR
0 1 K289‑ub AEDVATYkVNYTRWL
1 0 S307‑p HVPQSCDsLPRYETT
1 0 S372‑p EEIYGANsPIWESGF
0 1 T441 RTLPENLTLEDAkRL
0 1 K446‑ub NLTLEDAkRLRVMGD
1 0 K549‑ac LVFDPKHkTLALIKD
0 8 K721‑ac TGWKPLGkEKGKELK
0 34 Y734‑p LKDPDQLyttLKNLL
1 1 T735‑p KDPDQLyttLKNLLA
0 6 T736‑p DPDQLyttLKNLLAQ
0 1 K776‑ub IRFPIDLkTMTERLR
0 1 Y787‑p ERLRSRYyVTRkLFV
0 1 K791‑ub SRYyVTRkLFVADLQ
  mouse

 
T267 LNYWKLETPAQFRQR
K284 SEDVATYKVNYTRWL
S302 HVPQSCDSLPRYETT
S367 EEIYGANSPIWESGF
T434‑p RKLPENLtLEDAKRL
K439 NLtLEDAKRLRVMGD
K542 LVFDPKHKTLALIKD
K714‑ac TGWKPLGkEKGKELK
Y727‑p LKDPDQLyTtLKNLL
T728 KDPDQLyTtLKNLLA
T729‑p DPDQLyTtLKNLLAQ
K769 IRFPIDLKTMTERLR
Y780 ERLRSRYYVTRKLFV
K784 SRYYVTRKLFVADLQ
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