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Protein Page:
TRXR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TRXR1 a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity. Note: This description may include information from UniProtKB.
Protein type: EC 1.8.1.9; Nucleotide Metabolism - pyrimidine; Oxidoreductase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 12q23-q24.1
Cellular Component: cytosol
Molecular Function: protein binding; thioredoxin-disulfide reductase activity
Biological Process: nucleobase, nucleoside and nucleotide interconversion; response to reactive oxygen species; selenium metabolic process
Reference #:  Q16881 (UniProtKB)
Alt. Names/Synonyms: Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; GRIM12; KDRF; KM-102-derived reductase-like factor; MGC9145; oxidoreductase; thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; Thioredoxin reductase TR1; TR1; TRXR1; TXNR; TXNRD1
Gene Symbols: TXNRD1
Molecular weight: 70,906 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TRXR1

Protein Structure Not Found.
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Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 S160‑p GPEDLPKsyDyDLII
0 35 Y161‑p PEDLPKsyDyDLIII
0 48 Y163‑p DLPKsyDyDLIIIGG
0 1 K179‑ub SGGLAAAkEAAQyGK
0 1 Q183 AAAkEAAQyGKKVMV
0 1 Y184‑p AAkEAAQyGKKVMVL
0 1 T195‑p VMVLDFVtPtPLGTR
0 1 T197‑p VLDFVtPtPLGTRWG
0 1 K217‑ub VNVGCIPkkLMHQAA
0 3 K218‑ub NVGCIPkkLMHQAAL
0 1 Q231 ALLGQALQDSRNYGW
0 2 K239‑ac DSRNYGWkVEETVkH
0 3 K239‑ub DSRNYGWkVEETVkH
0 1 K245‑ac WkVEETVkHDWDRMI
0 3 K245‑ub WkVEETVkHDWDRMI
0 1 K245‑sc WkVEETVkHDWDRMI
0 1 K274 RVALREKKVVyENAy
0 23 Y277‑p LREKKVVyENAyGQF
0 563 Y281‑p KVVyENAyGQFIGPH
0 1 Q283 VyENAyGQFIGPHRI
0 1 R289 GQFIGPHRIKATNNK
0 1 K296 RIKATNNKGkEKIYS
0 2 K296 RIKATNNKGkEKIYS
0 1 K298‑ac KATNNKGkEKIYSAE
0 2 K300 TNNKGkEKIYSAERF
0 4 Y302 NKGkEKIYSAERFLI
0 1 Y350 TLVVGASYVALECAG
0 1 T367 AGIGLDVTVMVRSIL
0 3 K385‑ub FDQDMANkIGEHMEE
0 1 K396‑ub HMEEHGIkFIRQFVP
0 1 K405‑ac IRQFVPIkVEQIEAG
0 4 K405‑ub IRQFVPIkVEQIEAG
0 1 K405‑sm IRQFVPIkVEQIEAG
0 1 K405‑sc IRQFVPIkVEQIEAG
0 3 T413‑p VEQIEAGtPGRLRVV
0 1 Y434‑p EEIIEGEyNTVMLAI
0 2 K449‑ub GRDACTRkIGLETVG
0 2 K458 GLETVGVKINEKTGk
0 3 K458‑ub GLETVGVkINEKTGk
0 1 K465‑ub kINEKTGkIPVtDEE
0 1 T469‑p KTGkIPVtDEEQtNV
0 1 T474‑p PVtDEEQtNVPyIYA
0 1 Y478‑p EEQtNVPyIYAIGDI
0 1 T493‑p LEDKVELtPVAIQAG
0 1 Y555‑p NIEVYHSyFWPLEWT
0 1 Y572‑p SRDNNKCyAKIICNT
0 13 K580‑ub AKIICNTkDNERVVG
0 2 K607‑ub QGFAAALkCGLTKKQ
  TRXR1 iso2  
- gap
- gap
- gap
S54 GPEDLPKSYDYDLII
Y55 PEDLPKSYDYDLIII
Y57 DLPKSYDYDLIIIGG
K73 SGGLAAAKEAAQYGK
Q77 AAAKEAAQYGKKVMV
Y78 AAKEAAQYGKKVMVL
T89 VMVLDFVTPTPLGTR
T91 VLDFVTPTPLGTRWG
K111 VNVGCIPKKLMHQAA
K112 NVGCIPKKLMHQAAL
Q125 ALLGQALQDSRNYGW
K133 DSRNYGWKVEETVKH
K133 DSRNYGWKVEETVKH
K139 WKVEETVKHDWDRMI
K139 WKVEETVKHDWDRMI
K139 WKVEETVKHDWDRMI
K168 RVALREKKVVYENAY
Y171 LREKKVVYENAYGQF
Y175 KVVYENAYGQFIGPH
Q177 VYENAYGQFIGPHRI
R183 GQFIGPHRIKATNNK
K190 RIKATNNKGKEKIYS
K190 RIKATNNKGKEKIYS
K192 KATNNKGKEKIYSAE
K194 TNNKGKEKIYSAERF
Y196 NKGKEKIYSAERFLI
Y244 TLVVGASYVALECAG
T261 AGIGLDVTVMVRSIL
K279 FDQDMANKIGEHMEE
K290 HMEEHGIKFIRQFVP
K299 IRQFVPIKVEQIEAG
K299 IRQFVPIKVEQIEAG
K299 IRQFVPIKVEQIEAG
K299 IRQFVPIKVEQIEAG
T307 VEQIEAGTPGRLRVV
Y328 EEIIEGEYNTVMLAI
K343 GRDACTRKIGLETVG
K352 GLETVGVKINEKTGK
K352 GLETVGVKINEKTGK
K359 KINEKTGKIPVTDEE
T363 KTGKIPVTDEEQTNV
T368 PVTDEEQTNVPYIYA
Y372 EEQTNVPYIYAIGDI
T387 LEDKVELTPVAIQAG
Y449 NIEVYHSYFWPLEWT
Y466 SRDNNKCYAKIICNT
K474 AKIICNTKDNERVVG
K501 QGFAAALKCGLTKKQ
  TRXR1 iso3  
- gap
S30‑p RKPRPRRssRLLAGE
S31‑p KPRPRRssRLLAGEK
S109 GPEDLPKSYDYDLII
Y110 PEDLPKSYDYDLIII
Y112 DLPKSYDYDLIIIGG
K128 SGGLAAAKEAAQYGK
Q132 AAAKEAAQYGKKVMV
Y133 AAKEAAQYGKKVMVL
T144 VMVLDFVTPTPLGTR
T146 VLDFVTPTPLGTRWG
K166 VNVGCIPKKLMHQAA
K167 NVGCIPKKLMHQAAL
Q180 ALLGQALQDSRNYGW
K188 DSRNYGWKVEETVKH
K188 DSRNYGWKVEETVKH
K194 WKVEETVKHDWDRMI
K194 WKVEETVKHDWDRMI
K194 WKVEETVKHDWDRMI
K223 RVALREKKVVYENAY
Y226 LREKKVVYENAYGQF
Y230 KVVYENAYGQFIGPH
Q232 VYENAYGQFIGPHRI
R238 GQFIGPHRIKATNNK
K245 RIKATNNKGKEKIyS
K245 RIKATNNKGKEKIyS
K247 KATNNKGKEKIySAE
K249 TNNKGKEKIySAERF
Y251‑p NKGKEKIySAERFLI
Y299 TLVVGASYVALECAG
T316 AGIGLDVTVMVRSIL
K334 FDQDMANKIGEHMEE
K345 HMEEHGIKFIRQFVP
K354 IRQFVPIKVEQIEAG
K354 IRQFVPIKVEQIEAG
K354 IRQFVPIKVEQIEAG
K354 IRQFVPIKVEQIEAG
T362 VEQIEAGTPGRLRVV
Y383 EEIIEGEYNTVMLAI
K398 GRDACTRKIGLETVG
K407 GLETVGVKINEKTGK
K407 GLETVGVKINEKTGK
K414 KINEKTGKIPVTDEE
T418 KTGKIPVTDEEQTNV
T423 PVTDEEQTNVPYIYA
Y427 EEQTNVPYIYAIGDI
T442 LEDKVELTPVAIQAG
Y504 NIEVYHSYFWPLEWT
Y521 SRDNNKCYAKIICNT
K529 AKIICNTKDNERVVG
K556 QGFAAALKCGLTKKQ
  TRXR1 iso4  
S2‑p ______MsCEDGRAL
- gap
- gap
S62 GPEDLPKSYDYDLII
Y63 PEDLPKSYDYDLIII
Y65 DLPKSYDYDLIIIGG
K81 SGGLAAAKEAAQYGK
Q85 AAAKEAAQYGKKVMV
Y86 AAKEAAQYGKKVMVL
T97 VMVLDFVTPTPLGTR
T99 VLDFVTPTPLGTRWG
K119 VNVGCIPKKLMHQAA
K120 NVGCIPKKLMHQAAL
Q133 ALLGQALQDSRNYGW
K141 DSRNYGWKVEETVKH
K141 DSRNYGWKVEETVKH
K147 WKVEETVKHDWDRMI
K147 WKVEETVKHDWDRMI
K147 WKVEETVKHDWDRMI
K176 RVALREKKVVYENAY
Y179 LREKKVVYENAYGQF
Y183 KVVYENAYGQFIGPH
Q185 VYENAYGQFIGPHRI
R191 GQFIGPHRIKATNNK
K198 RIKATNNKGKEKIYS
K198 RIKATNNKGKEKIYS
K200 KATNNKGKEKIYSAE
K202 TNNKGKEKIYSAERF
Y204 NKGKEKIYSAERFLI
Y252 TLVVGASYVALECAG
T269 AGIGLDVTVMVRSIL
K287 FDQDMANKIGEHMEE
K298 HMEEHGIKFIRQFVP
K307 IRQFVPIKVEQIEAG
K307 IRQFVPIKVEQIEAG
K307 IRQFVPIKVEQIEAG
K307 IRQFVPIKVEQIEAG
T315 VEQIEAGTPGRLRVV
Y336 EEIIEGEYNTVMLAI
K351 GRDACTRKIGLETVG
K360 GLETVGVKINEKTGK
K360 GLETVGVKINEKTGK
K367 KINEKTGKIPVTDEE
T371 KTGKIPVTDEEQTNV
T376 PVTDEEQTNVPYIYA
Y380 EEQTNVPYIYAIGDI
T395 LEDKVELTPVAIQAG
Y457 NIEVYHSYFWPLEWT
Y474 SRDNNKCYAKIICNT
K482 AKIICNTKDNERVVG
K509 QGFAAALKCGLTKKQ
  mouse

 
T27 QTVWVAPTCPNCCWF
- gap
- gap
S124 GSKDPPGSYDFDLII
Y125 SKDPPGSYDFDLIII
F127 DPPGSYDFDLIIIGG
K143 SGGLAAAKEAAKFDK
K147 AAAKEAAKFDKKVLV
F148 AAKEAAKFDKKVLVL
T159 VLVLDFVTPTPLGTR
T161 VLDFVTPTPLGTRWG
K181 VNVGCIPKKLMHQAA
K182 NVGCIPKKLMHQAAL
K195‑ub ALLGQALkDSRNYGW
K203‑ac DSRNYGWkVEDTVkH
K203‑ub DSRNYGWkVEDTVkH
K209 WkVEDTVKHDWEKMT
K209‑ub WkVEDTVkHDWEKMT
K209 WkVEDTVKHDWEKMT
K238‑ub RVALREKkVVYENAy
Y241 LREKkVVYENAyGRF
Y245‑p kVVYENAyGRFIGPH
R247 VYENAyGRFIGPHRI
R253 GRFIGPHRIVATNNk
K260‑ac RIVATNNkGKEkIYS
K260‑ub RIVATNNkGKEkIYS
K262 VATNNkGKEkIYSAE
K264‑ac TNNkGKEkIYSAERF
Y266 NkGKEkIYSAERFLI
Y314‑p TLVVGASyVALECAG
T331‑p AGIGLDVtVMVRSIL
K349‑ub FDQDMANkIGEHMEE
K360 HMEEHGIKFIRQFVP
K369 IRQFVPTKIEQIEAG
K369‑ub IRQFVPTkIEQIEAG
K369 IRQFVPTKIEQIEAG
K369 IRQFVPTKIEQIEAG
T377 IEQIEAGTPGRLRVT
F398 EETIEGEFNTVLLAV
T413 GRDSCTRTIGLETVG
K422‑ac GLETVGVkINEKTGK
K422‑ub GLETVGVkINEKTGK
K429 kINEKTGKIPVTDEE
T433 KTGKIPVTDEEQTNV
T438 PVTDEEQTNVPYIYA
Y442 EEQTNVPYIYAIGDI
T457 LEGKLELTPVAIQAG
F519 NIEVYHSFFWPLEWT
Y536 SRDNNKCYAKIICNL
K544‑ub AKIICNLkDDERVVG
K571 QGFAAALKCGLTKQQ
  rat

 
- gap
- gap
- gap
S10 DSKDAPKSYDFDLII
Y11 SKDAPKSYDFDLIII
F13 DAPKSYDFDLIIIGG
K29 SGGLAAAKEAAkFDK
K33‑ac AAAKEAAkFDKKVMV
F34 AAKEAAkFDKKVMVL
T45 VMVLDFVTPTPLGTR
T47 VLDFVTPTPLGTRWG
K67 VNVGCIPKKLMHQAA
K68 NVGCIPKKLMHQAAL
K81 ALLGQALKDSRNYGW
K89 DSRNYGWKLEDTVKH
K89 DSRNYGWKLEDTVKH
K95 WKLEDTVKHDWEKMT
K95 WKLEDTVKHDWEKMT
K95 WKLEDTVKHDWEKMT
K124 RVALREKKVVYENAY
Y127 LREKKVVYENAYGkF
Y131 KVVYENAYGkFIGPH
K133‑ac VYENAYGkFIGPHkI
K139‑ac GkFIGPHkIMATNNK
K146 kIMATNNKGKEkVYS
K146 kIMATNNKGKEkVYS
K148 MATNNKGKEkVYSAE
K150‑ac TNNKGKEkVYSAERF
Y152 NKGKEkVYSAERFLI
Y200 TLVVGASYVALECAG
T217 AGIGLDVTVMVRSIL
K235 FDQDMANKIGEHMEE
K246 HMEEHGIKFIRQFVP
K255 IRQFVPTKIEQIEAG
K255 IRQFVPTKIEQIEAG
K255 IRQFVPTKIEQIEAG
K255 IRQFVPTKIEQIEAG
T263 IEQIEAGTPGRLKVT
F284 EETIEDEFNTVLLAV
T299 GRDSCTRTIGLETVG
K308‑ac GLETVGVkINEKTGK
K308 GLETVGVKINEKTGK
K315 kINEKTGKIPVTDEE
T319 KTGKIPVTDEEQTNV
T324 PVTDEEQTNVPYIYA
Y328 EEQTNVPYIYAIGDI
T343 LEGKLELTPVAIQAG
F405 NIEVYHSFFWPLEWT
Y422 SRDNNKCYAKVICNL
K430 AKVICNLKDNERVVG
K457 QGFAAALKCGLTKQQ
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