a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; transcription factor activity; ubiquitin-protein ligase activity
Biological Process: activation of NF-kappaB transcription factor; bypass DNA synthesis; innate immune response; negative regulation of interferon type I production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; protein monoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of virion penetration into host cell; response to estrogen stimulus