a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.. Note: This description may include information from UniProtKB.
Molecular Function: acid-amino acid ligase activity; protein binding; transcription factor activity; zinc ion binding
Biological Process: activation of NF-kappaB transcription factor; bypass DNA synthesis; cytokine and chemokine mediated signaling pathway; defense response to virus; DNA repair; innate immune response; negative regulation of interferon type I production; negative regulation of virion penetration into host cell; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; protein monoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of virion penetration into host cell; response to estrogen stimulus; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.