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Protein Page:
TIAL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TIAL1 a member of a family of RNA-binding proteins that possesses nucleolytic activity. A cytotoxic T cell granule-associated protein that has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. Members of this protein family may be involved in the induction of apoptosis. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA-binding
Chromosomal Location of Human Ortholog: 10q
Cellular Component: cytoplasm; lysosome; nucleoplasm; nucleus; stress granule
Molecular Function: AU-rich element binding; nucleotide binding; RNA binding
Biological Process: apoptosis; defense response; fibroblast growth factor receptor signaling pathway; germ cell development; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; stem cell division
Reference #:  Q01085 (UniProtKB)
Gene Symbols: TIAL1
Molecular weight: 41,591 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TIAL1

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S30 VLILQLFSQIGPCKS
0 16 - gap
0 1 - gap
0 7 - gap
0 20 Y50‑p EHTSNDPyCFVEFYE
0 3 T85‑p VKVNWATtPSSQKKD
0 3 S105‑p HVFVGDLsPEITTED
0 1 K122‑ac SAFAPFGkISDARVV
0 5 K122‑ub SAFAPFGkISDARVV
0 2 K130 ISDARVVKDMATGKS
0 7 Y140‑p ATGKSKGyGFVSFyN
0 3 Y146‑p GyGFVSFyNKLDAEN
0 7 S201‑p EDVVNQSsPKNCTVY
0 2 S226‑p QLMRQTFsPFGQIME
0 2 S278‑p KCYWGKEsPDMtKNF
0 1 T282‑p GKEsPDMtKNFQQVD
  TIAL1 iso2  
S30 VLILQLFSQIGPCKS
S52‑p PDSRRVNssVGFsVL
S53‑p DSRRVNssVGFsVLQ
S57‑p VNssVGFsVLQHTSN
Y67‑p QHTSNDPyCFVEFYE
T102 VKVNWATTPSSQKKD
S122 HVFVGDLSPEITTED
K139 SAFAPFGKISDARVV
K139 SAFAPFGKISDARVV
K147 ISDARVVKDMATGKS
Y157 ATGKSKGYGFVSFYN
Y163 GYGFVSFYNKLDAEN
S218 EDVVNQSSPKNCTVY
S243 QLMRQTFSPFGQIME
S295 KCYWGKESPDMTKNF
T299 GKESPDMTKNFQQVD
  mouse

 
S30‑p VLILQLFsQIGPCKS
S52 PDSRRVNSSVGFSVL
S53 DSRRVNSSVGFSVLQ
S57 VNSSVGFSVLQHTSN
Y67 QHTSNDPYCFVEFYE
T102 VKVNWATTPSSQKKD
S122 HVFVGDLSPEITTED
K139 SAFAPFGKISDARVV
K139‑ub SAFAPFGkISDARVV
K147‑ac ISDARVVkDMATGKS
Y157 ATGKSKGYGFVSFYN
Y163 GYGFVSFYNKLDAEN
S218 EDVVNQSSPKNCTVY
S243‑p QLMRQTFsPFGQIME
S295 KCYWGKESPDMTKNF
T299 GKESPDMTKNFQQVD
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