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Protein Page:
Arp3 (human)

Overview
Arp3 Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Belongs to the actin family. ARP3 subfamily. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q14.1
Cellular Component: actin cytoskeleton; Arp2/3 protein complex; cytosol; focal adhesion; membrane
Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton
Biological Process: cell motility; ephrin receptor signaling pathway
Reference #:  P61158 (UniProtKB)
Alt. Names/Synonyms: Actin-like protein 3; Actin-related protein 3; ACTR3; ARP3; ARP3 actin-related protein 3 homolog (yeast)
Gene Symbols: ACTR3
Molecular weight: 47,371 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Arp3

Protein Structure Not Found.
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