Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Methyltransferase; Methyltransferase, protein lysine; EC 18.104.22.168
Molecular Function: histone-lysine N-methyltransferase activity; metal ion binding
Biological Process: establishment of protein localization; myotube cell development; negative regulation of protein kinase activity; nucleosome assembly; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.