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Protein Page:
TGM2 (human)

Overview
TGM2 an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.3.2.13; Transferase
Chromosomal Location of Human Ortholog: 20q12
Cellular Component: cytosol; extracellular matrix; focal adhesion; intrinsic to plasma membrane; mitochondrion
Molecular Function: protein binding; protein-glutamine gamma-glutamyltransferase activity
Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration
Reference #:  P21980 (UniProtKB)
Alt. Names/Synonyms: C polypeptide; G-ALPHA-h; GNAH; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG(C); TG2; TGase C; TGase H; TGase-2; TGase-H; TGC; TGM2; Tissue transglutaminase; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase C; Transglutaminase H; Transglutaminase-2
Gene Symbols: TGM2
Molecular weight: 77,329 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TGM2

Protein Structure Not Found.
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