Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family. Note: This description may include information from UniProtKB.
Molecular Function: ATP binding; ATPase activity; chaperone binding; DNA replication origin binding; double-stranded RNA binding; insulin binding; lipopolysaccharide binding; misfolded protein binding; p53 binding; protease binding; protein binding; protein complex binding; protein heterodimerization activity; single-stranded DNA binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process: 'de novo' protein folding; B cell activation; B cell cytokine production; B cell proliferation; caspase activation; chaperone cofactor-dependent protein folding; chaperone-mediated protein complex assembly; detection of misfolded protein; isotype switching to IgG isotypes; MyD88-dependent toll-like receptor signaling pathway; negative regulation of apoptosis; negative regulation of neuron apoptosis; positive regulation of apoptosis; positive regulation of inflammatory response; positive regulation of interferon-alpha production; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of macrophage activation; positive regulation of T cell activation; positive regulation of T cell mediated immune response to tumor cell; protein maturation; protein refolding; protein stabilization; response to ATP; response to cocaine; response to cold; response to drug; response to estrogen stimulus; response to heat; response to hydrogen peroxide; response to hypoxia; response to lipopolysaccharide; response to unfolded protein; T cell activation; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.