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Protein Page:
ACTA1 (human)

Overview
ACTA1 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: actin cytoskeleton; actin filament; cytosol; extracellular space; filopodium; lamellipodium; sarcomere; stress fiber; striated muscle thin filament
Molecular Function: ADP binding; ATP binding; myosin binding; protein binding; structural constituent of cytoskeleton
Biological Process: muscle contraction; muscle filament sliding; muscle thin filament assembly; skeletal muscle fiber development
Disease: Myopathy, Congenital, With Fiber-type Disproportion; Myopathy, Scapulohumeroperoneal; Nemaline Myopathy 3
Reference #:  P68133 (UniProtKB)
Alt. Names/Synonyms: ACTA; ACTA1; actin, alpha 1, skeletal muscle; Actin, alpha skeletal muscle; ACTS; alpha skeletal muscle actin; Alpha-actin-1; ASMA; CFTD; CFTD1; CFTDM; MPFD; NEM1; NEM2; NEM3
Gene Symbols: ACTA1
Molecular weight: 42,051 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ACTA1

Protein Structure Not Found.
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