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Protein Page:
PSMD14 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSMD14 a component of the 26S proteasome. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Note: This description may include information from UniProtKB.
Protein type: Proteasome complex; Protease; EC 3.4.19.-
Chromosomal Location of Human Ortholog: 2q24.2
Cellular Component: cytosol; nucleoplasm; nucleus; proteasome complex
Molecular Function: metal ion binding; metallopeptidase activity; protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; response to ethanol; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  O00487 (UniProtKB)
Gene Symbols: PSMD14
Molecular weight: 34,577 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSMD14

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 57 Y32‑p VDTAEQVyIsSLALL
0 1 S34‑p TAEQVyIsSLALLKM
0 4 K43‑ub LALLKMLkHGRAGVP
0 1 K94‑ub VDPVFQAkMLDMLKQ
0 1 S150‑p VVVDPIQsVkGkVVI
0 24 K152‑ub VDPIQsVkGkVVIDA
0 21 K154‑ub PIQsVkGkVVIDAFR
0 5 K186‑ub SNLGHLNkPSIQALI
0 2 K209‑ub SITINYRkNELEQkM
0 1 K215‑ub RkNELEQkMLLNLHk
0 3 K222‑ub kMLLNLHkksWMEGL
0 1 K223‑ub MLLNLHkksWMEGLT
0 4 S224‑p LLNLHkksWMEGLTL
0 1 Y234‑p EGLTLQDySEHCKHN
0 4 K246‑ub KHNESVVkEMLELAk
0 5 K253‑ub kEMLELAkNYNkAVE
0 11 K257‑ub ELAkNYNkAVEEEDk
0 2 K264 kAVEEEDKMtPEQLA
0 2 K264‑ub kAVEEEDkMtPEQLA
0 12 T266‑p VEEEDkMtPEQLAIk
0 3 K273‑ub tPEQLAIkNVGkQDP
0 2 K277‑ub LAIkNVGkQDPKRHL
  mouse

 
Y32‑p VDTAEQVyISSLALL
S34 TAEQVyISSLALLKM
K43 LALLKMLKHGRAGVP
K94 VDPVFQAKMLDMLKQ
S150 VVVDPIQSVkGKVVI
K152‑ub VDPIQSVkGKVVIDA
K154 PIQSVkGKVVIDAFR
K186 SNLGHLNKPSIQALI
K209 SITINYRKNELEQKM
K215 RKNELEQKMLLNLHK
K222 KMLLNLHKKsWMEGL
K223 MLLNLHKKsWMEGLT
S224‑p LLNLHKKsWMEGLTL
Y234 EGLTLQDYSEHCKHN
K246‑ub KHNESVVkEMLELAK
K253 kEMLELAKNYNkAVE
K257‑ub ELAKNYNkAVEEEDk
K264‑ac kAVEEEDkMTPEQLA
K264 kAVEEEDKMTPEQLA
T266 VEEEDkMTPEQLAIk
K273‑ub TPEQLAIkNVGKQDP
K277 LAIkNVGKQDPKRHL
  rat

 
Y32‑p VDTAEQVyISSLALL
S34 TAEQVyISSLALLKM
K43 LALLKMLKHGRAGVP
K94 VDPVFQAKMLDMLKQ
S150 VVVDPIQSVKGKVVI
K152 VDPIQSVKGKVVIDA
K154 PIQSVKGKVVIDAFR
K186 SNLGHLNKPSIQALI
K209 SITINYRKNELEQKM
K215 RKNELEQKMLLNLHK
K222 KMLLNLHKKSWMEGL
K223 MLLNLHKKSWMEGLT
S224 LLNLHKKSWMEGLTL
Y234 EGLTLQDYSEHCKHN
K246 KHNESVVKEMLELAK
K253 KEMLELAKNYNKAVE
K257 ELAKNYNKAVEEEDk
K264‑ac KAVEEEDkMTPEQLA
K264 KAVEEEDKMTPEQLA
T266 VEEEDkMTPEQLAIK
K273 TPEQLAIKNVGKQDP
K277 LAIKNVGKQDPKRHL
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