Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
TH iso3 (human)

Overview
TH iso3 an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; internal side of plasma membrane; melanosome membrane; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum
Molecular Function: enzyme binding; protein binding; tyrosine 3-monooxygenase activity
Biological Process: anatomical structure morphogenesis; catecholamine biosynthetic process; dopamine biosynthetic process; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; heart development; learning; locomotory behavior; memory; norepinephrine biosynthetic process; organ morphogenesis; pigmentation; regulation of heart contraction; response to ethanol; response to hypoxia; synaptic transmission, dopaminergic; visual perception
Reference #:  P07101-3 (UniProtKB)
Alt. Names/Synonyms: dystonia 14; DYT14; DYT5b; TH; TY3H; TYH; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols: TH
Molecular weight: 55,612 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease
Select Structure to View Below

TH iso3

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


cBioPortal  |  Wikipedia  |  Scansite  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein