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Protein Page:
TH iso3 (human)

Overview
TH iso3 an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Oxidoreductase; Vesicle; Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; dendrite; internal side of plasma membrane; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum; synaptic vesicle; terminal button
Molecular Function: amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; oxygen binding; protein binding; protein domain specific binding; tyrosine 3-monooxygenase activity
Biological Process: anatomical structure morphogenesis; catecholamine biosynthetic process; cerebral cortex development; circadian sleep/wake cycle; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; heart morphogenesis; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; multicellular organismal aging; neurotransmitter biosynthetic process; norepinephrine biosynthetic process; organ morphogenesis; phthalate metabolic process; phytoalexin metabolic process; pigmentation; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone stimulus; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to light stimulus; response to lipopolysaccharide; response to nutrient levels; response to peptide hormone stimulus; response to pyrethroid; response to salt stress; response to water deprivation; response to zinc ion; sensory perception of sound; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; synaptic vesicle amine transport; terpene metabolic process; visual perception
Reference #:  P07101-3 (UniProtKB)
Alt. Names/Synonyms: dystonia 14; DYT14; DYT5b; TH; TY3H; TYH; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols: TH
Molecular weight: 55,612 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease
Select Structure to View Below

TH iso3

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
enzymatic activity, induced: S31‑p, S40‑p
molecular association, regulation: S19‑p
phosphorylation: S31‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T3‑p _____MPtPDATTPQ
5 1 T8 MPtPDATTPQAKGFR
38 11 S19‑p KGFRRAVsELDAKQA
0 1 A23 RAVsELDAKQAEAIM
0 1 M30 AKQAEAIMVRGQGAP
35 7 S62‑p SYTPTPRsPRFIGRR
52 14 S71‑p RFIGRRQsLIEDARK
0 1 S118‑p AVLNLLFsPRATKPS
1 0 S183 LSGVRQVSEDVRSPA
0 1 Y230‑p PGFSDQVyRQRRKLI
0 1 Y419‑p QNGEVKAyGAGLLSS
1 0 S435 GELLHCLSEEPEIRA
0 4 S502‑p LAIDVLDsPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso2  
T3 _____MPTPDATTPQ
T8 MPTPDATTPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMGAPGPSL
S58‑p SYTPTPRsPRFIGRR
S67‑p RFIGRRQsLIEDARK
S114 AVLNLLFSPRATKPS
S179 LSGVRQVSEDVRSPA
Y226 PGFSDQVYRQRRKLI
Y415 QNGEVKAYGAGLLSS
S431 GELLHCLSEEPEIRA
S498 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso3  
T3 _____MPTPDATTPQ
T8 MPTPDATTPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMsPRFIGR
S31‑p KQAEAIMsPRFIGRR
S40‑p RFIGRRQsLIEDARK
S87 AVLNLLFSPRATKPS
S152 LSGVRQVSEDVRSPA
Y199 PGFSDQVYRQRRKLI
Y388 QNGEVKAYGAGLLSS
S404‑p GELLHCLsEEPEIRA
S471 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso4  
T3 _____MPTPDATTPQ
T8 MPTPDATTPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMVRGQsPR
S35‑p AIMVRGQsPRFIGRR
S44‑p RFIGRRQsLIEDARK
S91 AVLNLLFSPRATKPS
S156 LSGVRQVSEDVRSPA
Y203 PGFSDQVYRQRRKLI
Y392 QNGEVKAYGAGLLSS
S408 GELLHCLSEEPEIRA
S475 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  mouse

 
T3 _____MPTPSASSPQ
S8 MPTPSASSPQPKGFR
S19‑p KGFRRAVsEQDtKQA
T23‑p RAVsEQDtKQAEAVt
T30‑p tKQAEAVtsPRFIGR
S31‑p KQAEAVtsPRFIGRR
S40‑p RFIGRRQsLIEDARK
S88 AVLNLLFSLRGTKPS
S153 LSSVRRVSDDVRSAR
Y200 PGFSDQAYRQRRKLI
Y389 QNGELKAYGAGLLSS
S405 GELLHSLSEEPEVRA
S472‑p LAIDVLDsPHTIRRS
3370 : Phospho-Tyrosine Hydroxylase (Ser31) Antibody
13041 : Phospho-Tyrosine Hydroxylase (Ser31) (D6I9V) Rabbit mAb
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  rat

 
T3 _____MPTPSAPsPQ
S8‑p MPTPSAPsPQPKGFR
S19‑p KGFRRAVsEQDAKQA
A23 RAVsEQDAKQAEAVT
T30 AKQAEAVTsPRFIGR
S31‑p KQAEAVTsPRFIGRR
S40‑p RFIGRRQsLIEDARK
S88 AVLNLLFSLRGTKPS
S153‑p LSSVRRVsDDVRSAR
Y200 PGFSDQVYRQRRKLI
Y389 QNGELKAYGAGLLSS
S405 GELLHSLSEEPEVRA
S472‑p LAIDVLDsPHTIQRS
3370 : Phospho-Tyrosine Hydroxylase (Ser31) Antibody
13041 : Phospho-Tyrosine Hydroxylase (Ser31) (D6I9V) Rabbit mAb
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  cow

 
T3 _____MPTPNAASPQ
S8 MPTPNAASPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMsPRFVGR
S31‑p KQAEAIMsPRFVGRR
S40‑p RFVGRRQsLIQDARK
A81 AVLTLLFALPPTRPP
A146 LSALRRVAEDVRAAG
Y193 PGFSDQAYRQRRKLI
Y382 QNGEVKAYGAGLLSS
S398 GELLHSLSEEPEIRA
S465 LAIDVLDSPHAIRHA
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