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Protein Page:
hnRNP P2 (human)

Overview
hnRNP P2 Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP. Ubiquitous. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; RNA binding; transcription coactivator activity
Biological Process: nuclear mRNA splicing, via spliceosome
Disease: Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia; Tremor, Hereditary Essential, 4
Reference #:  P35637 (UniProtKB)
Alt. Names/Synonyms: 75 kDa DNA-pairing protein; ALS6; FUS; fus-like protein; FUS1; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; HNRNPP2; Oncogene FUS; Oncogene TLS; POMp75; RNA-binding protein FUS; TLS; Translocated in liposarcoma protein
Gene Symbols: FUS
Molecular weight: 53,426 Da
Basal Isoelectric point: 9.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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hnRNP P2

Protein Structure Not Found.
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