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Protein Page:
mGluR1 (human)

mGluR1 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6q24.3
Cellular Component: integral to plasma membrane; plasma membrane; postsynaptic density; presynaptic membrane
Molecular Function: G-protein coupled receptor activity; glutamate receptor activity; protein binding
Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; metabotropic glutamate receptor signaling pathway; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; regulation of synaptic transmission, glutamatergic; synaptic transmission
Disease: Spinocerebellar Ataxia, Autosomal Recessive 13
Reference #:  Q13255 (UniProtKB)
Alt. Names/Synonyms: glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A
Gene Symbols: GRM1
Molecular weight: 132,357 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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