a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral
Cellular Component: cell surface; external side of plasma membrane; extracellular space; focal adhesion; immunological synapse; integral to membrane; integral to plasma membrane; lipid raft; membrane; plasma membrane
Molecular Function: integrin binding; protein complex binding
Biological Process: activation of NF-kappaB transcription factor; acute inflammatory response to antigenic stimulus; adhesion to host; cell adhesion; cell adhesion mediated by integrin; cell-cell adhesion; leukocyte adhesion; negative regulation of calcium ion transport; positive regulation of actin filament polymerization; positive regulation of cellular extravasation; positive regulation of GTPase activity; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vasoconstriction; regulation of cell adhesion; regulation of cell shape; sensory perception of sound; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; T cell antigen processing and presentation; virion attachment, binding of host cell surface receptor
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.