a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral
Biological Process: adhesion to host; cell adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; leukocyte adhesion; leukocyte migration; membrane to membrane docking; positive regulation of cellular extravasation; regulation of immune response; regulation of leukocyte mediated cytotoxicity; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; virion attachment, binding of host cell surface receptor
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.