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Protein Page:
ICAM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ICAM1 a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.3-p13.2
Cellular Component: cell surface; extracellular space; focal adhesion; integral to plasma membrane; membrane; plasma membrane
Molecular Function: integrin binding; protein binding; receptor activity; transmembrane receptor activity
Biological Process: adhesion to host; cell adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; leukocyte adhesion; leukocyte migration; membrane to membrane docking; positive regulation of cellular extravasation; regulation of immune response; regulation of leukocyte mediated cytotoxicity; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; virion attachment, binding of host cell surface receptor
Disease: Malaria, Susceptibility To
Reference #:  P05362 (UniProtKB)
Alt. Names/Synonyms: BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; ICAM-1; ICAM1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Major group rhinovirus receptor; P3.58
Gene Symbols: ICAM1
Molecular weight: 57,825 Da
Basal Isoelectric point: 8.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ICAM1

Protein Structure Not Found.
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Sites Implicated In
cell adhesion, altered: Y512‑p
cell motility, altered: Y512‑p
molecular association, regulation: Y512‑p
protein processing: Y501‑p, Y512‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S43‑p VILPRGGsVLVTCST
0 1 T62‑ga PKLLGIEtPLPKKEL
0 1 T62‑p PKLLGIEtPLPKKEL
0 1 K158 LRGEKELKREPAVGE
0 1 Y207‑p FENTSAPyQLQtFVL
0 1 T211‑p SAPyQLQtFVLPAtP
0 1 T217‑p QtFVLPAtPPQLVsP
0 1 S223‑p AtPPQLVsPRVLEVD
0 1 S275‑p DSFSAKAsVSVTAED
0 2 K359‑ub PRAQLLLkATPEDNG
1 0 Y501‑p GTAGLSTyLYNRQRK
5 2 Y512‑p RQRKIKKyRLQQAQk
0 1 Q516 IKKyRLQQAQkGtPM
0 3 K519‑ub yRLQQAQkGtPMkPN
0 11 T521‑p LQQAQkGtPMkPNtQ
0 28 K524‑ub AQkGtPMkPNtQAtP
0 3 T527‑p GtPMkPNtQAtPP__
0 13 T530‑p MkPNtQAtPP_____
  mouse

 
S43 AFLPQGGSVQVNCSS
T62 DLSLGLETQWLKDEL
T62 DLSLGLETQWLKDEL
S157‑p LRGEEILsRQPVGGH
R209 FSNVSEARSLRTFDL
T213 SEARSLRTFDLPATI
T219 RTFDLPATIPKLDTP
T225 ATIPKLDTPDLLEVG
L277 DSVSATALVEVTEEF
- gap
Y507 GLVMAASYVYNRQRK
Y518‑p RQRKIRIyKLQkAQE
K522‑ub IRIyKLQkAQEEAIk
- gap
- gap
K529‑ub kAQEEAIkLKGQAPP
- gap
- gap
  rat

 
S43 AFLPRGGSVQVNCSS
T63 NLGLGLETNWMKDEL
T63 NLGLGLETNWMKDEL
S158 LRGNETLSRQAVDGD
R207 FKNVSEVRQLRTFDL
T211 SEVRQLRTFDLPTRV
- gap
T223 TRVLKLDTPDLLEVG
S275 DFVSATASVEVTEKL
- gap
Y515 FVIVASIYTYYRQRK
Y526 RQRKIRIYKLQKAQE
K530 IRIYKLQKAQEEALK
- gap
- gap
K537 KAQEEALKLKVQAPP
- gap
- gap
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