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Protein Page:
XIAP (human)

Overview
XIAP an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; spindle microtubule
Molecular Function: caspase inhibitor activity; identical protein binding; protein binding; ubiquitin-protein ligase activity
Biological Process: copper ion homeostasis; negative regulation of apoptosis; negative regulation of caspase activity; positive regulation of protein ubiquitination; regulation of BMP signaling pathway; regulation of cell proliferation; regulation of inflammatory response; regulation of innate immune response; response to DNA damage stimulus
Disease: Lymphoproliferative Syndrome, X-linked, 1; Lymphoproliferative Syndrome, X-linked, 2
Reference #:  P98170 (UniProtKB)
Alt. Names/Synonyms: API3; apoptosis inhibitor 3; baculoviral IAP repeat-containing 4; Baculoviral IAP repeat-containing protein 4; BIRC4; E3 ubiquitin-protein ligase XIAP; hIAP-3; hIAP3; hILP; IAP-3; IAP-like protein; IAP3; ILP; ILP1; Inhibitor of apoptosis protein 3; MIHA; X-linked IAP; X-linked inhibitor of apoptosis; X-linked inhibitor of apoptosis protein; XIAP; XLP2
Gene Symbols: XIAP
Molecular weight: 56,685 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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XIAP

Protein Structure Not Found.
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