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Protein Page:
BATF (human)

Overview
BATF a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13- acetate response element (TRE) and weaker at the cAMP responsive region (CRE), but are transcriptionally inert. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: cytokine production; defense response to protozoan; DNA damage response, signal transduction by p53 class mediator; isotype switching; lymphoid progenitor cell differentiation; myeloid dendritic cell differentiation; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; T-helper 2 cell differentiation; transcription from RNA polymerase II promoter
Reference #:  Q16520 (UniProtKB)
Alt. Names/Synonyms: activating transcription factor B; B-ATF; B-cell-activating transcription factor; basic leucine zipper transcription factor, ATF-like; Basic leucine zipper transcriptional factor ATF-like; BATF; BATF1; SF-HT-activated gene 2 protein; SFA-2; SFA2
Gene Symbols: BATF
Molecular weight: 14,120 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BATF

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: S43‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S13 DSSDSSFSRSPPPGK
0 1 S15 SDSSFSRSPPPGKQD
1 0 S43‑p NRIAAQKsRQRQtQK
1 0 T48‑p QKsRQRQtQKADTLH
0 1 T76‑p RKEIKQLtEELKYFT
  mouse

 
S13‑p DSSDSSFsRsPPPGK
S15‑p SDSSFsRsPPPGKQD
S43 NRIAAQKSRQRQTQK
T48 QKSRQRQTQKADTLH
T76 RKEIKQLTEELKYFT
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