a scaffold protein that connects plasma membrane proteins with members of the Ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized beta-2-adrenergic receptor Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Molecular Function: beta-2 adrenergic receptor binding; beta-catenin binding; chloride channel regulator activity; dopamine receptor binding; PDZ domain binding; phosphatase binding; protein binding; protein complex binding; protein complex scaffold; protein self-association; receptor binding
Biological Process: actin cytoskeleton organization and biogenesis; auditory receptor cell stereocilium organization and biogenesis; bile acid secretion; cellular phosphate ion homeostasis; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; establishment of epithelial cell polarity; establishment of Golgi localization; establishment of nucleus localization; gland morphogenesis; microvillus biogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase B signaling cascade; negative regulation of sodium:hydrogen antiporter activity; protein complex assembly; regulation of cell shape; regulation of cell size; regulation of protein kinase activity; regulation of sodium:hydrogen antiporter activity; renal sodium ion transport; sensory perception of sound; Wnt receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.