a scaffold protein that connects plasma membrane proteins with members of the Ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized beta-2-adrenergic receptor Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Biological Process: bile acid secretion; establishment of epithelial cell polarity; establishment of Golgi localization; establishment of nucleus localization; gland morphogenesis; microvillus biogenesis; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase B signaling cascade; protein complex assembly; regulation of cell shape; regulation of cell size; regulation of protein kinase activity