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Protein Page:
EIF6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EIF6 eukaryotic translation initiation factor 6. Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex. Note: This description may include information from UniProtKB.
Protein type: Translation; Nucleolus; Translation initiation
Chromosomal Location of Human Ortholog: 20q12
Cellular Component: cytoplasm; cytosol; nucleolus; nucleoplasm; nucleus
Molecular Function: protein binding; ribosomal large subunit binding; ribosome binding
Biological Process: maturation of 5.8S rRNA; maturation of LSU-rRNA; mature ribosome assembly; miRNA-mediated gene silencing; miRNA-mediated gene silencing, negative regulation of translation; positive regulation of translation; regulation of fatty acid biosynthetic process; regulation of glycolysis; regulation of megakaryocyte differentiation; response to insulin stimulus; ribosome export from nucleus
Reference #:  P56537 (UniProtKB)
Alt. Names/Synonyms: 2; b; b(2)gcn; B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; EIF3A; EIF6; eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; gcn; IF6; integrin beta 4 binding protein; ITGB4BP; p27 beta-4 integrin-binding protein; p27(BBP); p27BBP
Gene Symbols: EIF6
Molecular weight: 26,599 Da
Basal Isoelectric point: 4.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EIF6

Protein Structure Not Found.


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Sites Implicated In
translation, altered: S235‑p
intracellular localization: S174‑p, S175‑p
molecular association, regulation: S235‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S6‑p __MAVRAsFENNCEI
0 1 I53 IPVVHASIAGCRIIG
0 11 Y113‑p NVTTCNDyVALVHPD
0 1 S150‑p ADQVLVGsYCVFSNQ
1 0 S174‑p IEDQDELssLLQVPL
1 1 S175‑p EDQDELssLLQVPLV
0 1 T185‑p QVPLVAGtVNRGSEV
0 1 K223‑ac SVVESVFkLNEAQPs
0 1 Q228 VFkLNEAQPstIAts
0 1 Q228 VFkLNEAQPstIAts
0 1 S230‑p kLNEAQPstIAtsMR
0 1 T231‑p LNEAQPstIAtsMRD
0 1 T234‑p AQPstIAtsMRDsLI
3 5 S235‑p QPstIAtsMRDsLID
0 8 S239‑p IAtsMRDsLIDsLt_
0 11 S243‑p MRDsLIDsLt_____
0 5 T245‑p DsLIDsLt_______
  EIF6 iso2  
S6 __MAVRASFENNCEI
S40‑p NFYRCGGsPGAYGGG
- gap
S131 ADQVLVGSYCVFSNQ
S155 IEDQDELSSLLQVPL
S156 EDQDELSSLLQVPLV
T166 QVPLVAGTVNRGSEV
K204 SVVESVFKLNEAQPS
Q209 VFKLNEAQPSTIATS
Q209 VFKLNEAQPSTIATS
S211 KLNEAQPSTIATSMR
T212 LNEAQPSTIATSMRD
T215 AQPSTIATSMRDSLI
S216 QPSTIATSMRDSLID
S220 IATSMRDSLIDSLT_
S224 MRDSLIDSLT_____
T226 DSLIDSLT_______
  mouse

 
S6 __MAVRASFENNCEV
I53 IPVVHASIAGCRIIG
Y113 NVTTCNDYVALVHPD
S150‑p ADQVLVGsYCVFSNQ
S174 IEDQDELSSLLQVPL
S175 EDQDELSSLLQVPLV
T185 QVPLVAGTVNRGSEV
K223 SVVESVFKLNEAkPS
K228‑ac VFKLNEAkPSTIATS
K228‑ub VFKLNEAkPSTIATS
S230 KLNEAkPSTIATSMR
T231 LNEAkPSTIATSMRD
T234 AkPSTIATSMRDsLI
S235 kPSTIATSMRDsLID
S239‑p IATSMRDsLIDsLt_
S243‑p MRDsLIDsLt_____
T245‑p DsLIDsLt_______
  rat

 
S6 __MAVRASFENNCEV
I53 IPVVHASIAGCRIIG
Y113 NVTTCNDYVALVHPD
S150 ADQVLVGSYCVFSNQ
S174 IEDQDELSSLLQVPL
S175 EDQDELSSLLQVPLV
T185 QVPLVAGTVNRGSEV
K223 SVVESVFKLNEAKPS
K228 VFKLNEAKPSTIATS
K228 VFKLNEAKPSTIATS
S230 KLNEAKPSTIATSMR
T231 LNEAKPSTIATSMRD
T234 AKPSTIATSMRDSLI
S235 KPSTIATSMRDSLID
S239 IATSMRDSLIDsLt_
S243‑p MRDSLIDsLt_____
T245‑p DSLIDsLt_______
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