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Protein Page:
PSMA2 (human)

PSMA2 a proteasomal protein of the T1A peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The component C3 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Proteasome complex
Chromosomal Location of Human Ortholog: 7p13
Cellular Component: cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex
Molecular Function: protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; response to virus; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P25787 (UniProtKB)
Alt. Names/Synonyms: HC3; Macropain subunit C3; MU; Multicatalytic endopeptidase complex subunit C3; PMSA2; proteasome (prosome, macropain) subunit, alpha type, 2; Proteasome component C3; Proteasome subunit alpha type-2; proteasome subunit HC3; PSA2; PSC2; PSC3; PSMA2
Gene Symbols: PSMA2
Molecular weight: 25,899 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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