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Protein Page:
Caveolin-2 (human)

Overview
Caveolin-2 a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component: acrosomal membrane; caveola; cytoplasmic vesicle; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; Golgi membrane; integral to plasma membrane; intracellular; lipid raft; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; transport vesicle
Molecular Function: D1 dopamine receptor binding; protein binding; protein binding, bridging; protein complex scaffold; protein heterodimerization activity; protein homodimerization activity; protein kinase binding
Biological Process: endoplasmic reticulum organization and biogenesis; insulin receptor signaling pathway; mitochondrion organization and biogenesis; negative regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAPKKK cascade; protein oligomerization; receptor mediated endocytosis of virus by host; regulation of mitosis; skeletal muscle fiber development; vesicle docking; vesicle fusion; vesicle organization and biogenesis
Reference #:  P51636 (UniProtKB)
Alt. Names/Synonyms: CAV; CAV2; caveolae protein, 20-kD; caveolin 2; caveolin 2 isoform a and b; Caveolin-2; MGC12294
Gene Symbols: CAV2
Molecular weight: 18,291 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Caveolin-2

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S23‑p, S36‑p, S135‑p
intracellular localization: Y19‑p, Y27‑p
molecular association, regulation: Y19‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 44 S18‑p QLFMDDDsysHHsGL
9 33 Y19‑p LFMDDDsysHHsGLE
1 49 S20‑p FMDDDsysHHsGLEy
4 101 S23‑p DDsysHHsGLEyADP
6 39 Y27‑p sHHsGLEyADPEKFA
0 2 F33 EyADPEKFADsDQDR
3 7 S36‑p DPEKFADsDQDRDPH
0 1 S47 RDPHRLNSHLKLGFE
0 1 T121‑p ILMPFVKtCLMVLPs
0 1 S128‑p tCLMVLPsVQtIWKs
0 1 T131‑p MVLPsVQtIWKsVTD
1 0 S135‑p sVQtIWKsVTDVIIA
0 4 S153 TSVGRCFSSVSLQLS
0 2 S154 SVGRCFSSVSLQLSQ
0 3 S156 GRCFSSVSLQLSQD_
0 1 S160 SSVSLQLSQD_____
  Caveolin-2 iso2  
S5 ___MDDDSYSHHSGL
Y6 __MDDDSYSHHSGLE
S7 _MDDDSYSHHSGLEY
S10 DDSYSHHSGLEYADP
Y14 SHHSGLEYADPEKFA
F20 EYADPEKFADSDQDR
S23 DPEKFADSDQDRDPH
S34 RDPHRLNSHLKLGFE
T108 ILMPFVKTCLMVLPS
S115 TCLMVLPSVQTIWKS
T118 MVLPSVQTIWKSVTD
S122 SVQTIWKSVTDVIIA
S140 TSVGRCFSSVSLQLS
S141 SVGRCFSSVSLQLSQ
S143 GRCFSSVSLQLSQD_
S147 SSVSLQLSQD_____
  Caveolin-2 iso3  
S18 QLFMDDDSYSHHSGL
Y19 LFMDDDSYSHHSGLE
S20 FMDDDSYSHHSGLEY
S23 DDSYSHHSGLEYADP
Y27 SHHSGLEYADPEKFA
F33 EYADPEKFADSDQDR
S36 DPEKFADSDQDRDPH
S47 RDPHRLNSHLKDFNA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
A18 QLFMADDAysHHsGV
Y19‑p LFMADDAysHHsGVD
S20‑p FMADDAysHHsGVDy
S23‑p DDAysHHsGVDyADP
Y27‑p sHHsGVDyADPEKyV
Y33‑p DyADPEKyVDSSHDR
S36 DPEKyVDSSHDRDPH
S47‑p RDPHQLNsHLKLGFE
T121 ILMPFVKTCLMVLPS
S128 TCLMVLPSVQTIWKS
T131 MVLPSVQTIWKSVTD
S135 SVQTIWKSVTDVVIG
S153‑p TSVGRSFssVsMQLs
S154‑p SVGRSFssVsMQLsH
S156‑p GRSFssVsMQLsHD_
S160‑p ssVsMQLsHD_____
  rat

 
A18 QLFMADDAysHHSVV
Y19‑p LFMADDAysHHSVVD
S20‑p FMADDAysHHSVVDy
S23 DDAysHHSVVDyTDP
Y27‑p sHHSVVDyTDPEKYV
Y33 DyTDPEKYVDSSQDR
S36 DPEKYVDSSQDRDPH
S47 RDPHQLNSHLKLGFE
T121 ILMPFVKTCLMVLPS
S128 TCLMVLPSVQTIWKS
T131 MVLPSVQTIWKSVTD
S135 SVQTIWKSVTDVVIG
S153 TSVGRIFSSVSMQLS
S154 SVGRIFSSVSMQLSH
S156 GRIFSSVSMQLSHD_
S160 SSVSMQLSHD_____
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