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Protein Page:
Caveolin-2 (human)

Caveolin-2 a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component: caveola; cytoplasmic vesicle; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; integral to plasma membrane; intracellular; lipid raft; perinuclear region of cytoplasm; plasma membrane; protein complex; transport vesicle
Molecular Function: protein binding; protein homodimerization activity
Biological Process: endoplasmic reticulum organization and biogenesis; insulin receptor signaling pathway; mitochondrion organization and biogenesis; negative regulation of endothelial cell proliferation; positive regulation of dopamine receptor signaling pathway; positive regulation of GTPase activity; positive regulation of MAPKKK cascade; receptor mediated endocytosis of virus by host; regulation of mitosis; skeletal muscle fiber development; vesicle docking; vesicle fusion; vesicle organization and biogenesis
Reference #:  P51636 (UniProtKB)
Alt. Names/Synonyms: CAV; CAV2; caveolae protein, 20-kD; caveolin 2; caveolin 2 isoform a and b; Caveolin-2; MGC12294
Gene Symbols: CAV2
Molecular weight: 18,291 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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