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Protein Page:
ITGB4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGB4 integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: cell junction; cell surface; hemidesmosome; leading edge; nucleus; plasma membrane; receptor complex
Molecular Function: G-protein-coupled receptor binding; insulin-like growth factor I binding; protein binding
Biological Process: autophagy; cell motility involved in cell locomotion; cell-matrix adhesion; extracellular matrix organization and biogenesis; gut development; hemidesmosome assembly; mesodermal cell differentiation; response to wounding; skin development
Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa, Junctional, Non-herlitz Type
Reference #:  P16144 (UniProtKB)
Alt. Names/Synonyms: CD104; CD104 antigen; GP150; Integrin beta-4; integrin beta-4 subunit; integrin, beta 4; ITB4; ITGB4
Gene Symbols: ITGB4
Molecular weight: 202,167 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGB4

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cell motility, altered: S1356‑p, S1364‑p
cytoskeletal reorganization: S1356‑p, S1364‑p
intracellular localization: S1494‑p
molecular association, regulation: S1325‑p, S1356‑p, S1360‑p, S1364‑p, Y1492‑p, Y1510‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S7‑p _MAGPRPsPWARLLL
0 1 S21‑p LAALISVsLSGTLAN
0 1 Y50‑p RVDKDCAyCTDEMFR
0 2 S102‑p TLRRSQMsPQGLRVR
0 1 T164‑p ARVLSQLtsDyTIGF
0 1 S165‑p RVLSQLtsDyTIGFG
0 1 Y167‑p LSQLtsDyTIGFGkF
0 1 K173‑ub DyTIGFGkFVDkVSV
0 1 K177‑ub GFGkFVDkVSVPQTD
0 1 K191‑ub DMRPEKLkEPWPNSD
0 1 T210‑p FKNVISLtEDVDEFR
0 1 K219‑ub DVDEFRNkLQGERIS
0 1 S368‑p EAFNRIRsNLDIRAL
0 1 S377‑p LDIRALDsPRGLRtE
0 1 T383‑p DsPRGLRtEVTskMF
0 1 S387‑p GLRtEVTskMFQKTR
0 1 K388‑ub LRtEVTskMFQKTRT
0 1 S397‑p FQKTRTGsFHIRRGE
0 1 Y408‑p RRGEVGIyQVQLRAL
0 1 K437‑ub QKGNIHLkPSFSDGL
0 1 K437‑sm QKGNIHLkPSFSDGL
0 1 K654 TCEECNFKVKMVDEL
0 1 K656 EECNFKVKMVDELkR
0 1 K662‑ub VKMVDELkRAEEVVV
0 1 T681‑p RDEDDDCtYSYTMEG
0 1 K758‑ub RGHMVGFkEDHyMLR
0 1 Y762‑p VGFkEDHyMLRENLM
0 1 S771 LRENLMASDHLDtPM
0 1 T776‑p MASDHLDtPMLRSGN
0 1 K785‑ub MLRSGNLkGRDVVRW
0 1 S809‑p GFATHAAsINPTELV
0 1 S821‑p ELVPYGLsLRLARLC
0 1 T829‑p LRLARLCtENLLkPD
0 2 K834‑ub LCtENLLkPDtRECA
0 1 T837‑p ENLLkPDtRECAQLR
0 33 Y855‑p EENLNEVyRQISGVH
0 1 T886‑p QDHTIVDtVLMAPRS
0 1 K895‑ub LMAPRSAkPALLKLT
0 1 K904‑ub ALLKLTEkQVEQRAF
0 3 K915‑ub QRAFHDLkVAPGyyt
0 66 Y920‑p DLkVAPGyytLTADQ
0 11 Y921‑p LkVAPGyytLTADQD
0 2 T922‑p kVAPGyytLTADQDA
0 1 K958‑ub RPEDDDEkQLLVEAI
0 2 T973‑p DVPAGTAtLGRRLVN
0 1 T982‑p GRRLVNItIIKEQAR
0 1 S1000‑p SFEQPEFsVSRGDQV
0 1 K1021‑ub RRVLDGGkSQVSYRT
0 2 Y1039‑p TAQGNRDyIPVEGEL
0 1 K1060‑ub AWKELQVkLLELQEV
1 9 S1069‑p LELQEVDsLLRGRQV
0 2 S1084‑p RRFHVQLsNPKFGAH
0 1 S1097‑p AHLGQPHsttIIIRD
0 1 T1098‑p HLGQPHsttIIIRDP
0 1 T1099‑p LGQPHsttIIIRDPD
0 1 S1119 FTSQMLSSQPPPHGD
0 1 S1140‑p PNAKAAGsRKIHFNW
0 1 S1167‑p KYWIQGDsESEAHLL
0 24 Y1187‑p SVELTNLyPyCDYEM
0 54 Y1189‑p ELTNLyPyCDYEMKV
0 599 Y1207‑p GAQGEGPyssLVSCR
0 41 S1208‑p AQGEGPyssLVSCRT
0 87 S1209‑p QGEGPyssLVSCRTH
0 2 T1246‑p SWAEPAEtNGEITAY
1 0 Y1257‑p ITAYEVCyGLVNDDN
0 1 Y1294 NLRESQPYRYtVKAR
0 1 T1297‑p ESQPYRYtVKARNGA
0 1 T1318‑p EAIINLAtQPKRPMs
1 0 S1325‑p tQPKRPMsIPIIPDI
0 15 Y1343‑p DAQSGEDyDsFLMys
0 4 S1345‑p QSGEDyDsFLMysDD
0 7 Y1349‑p DyDsFLMysDDVLRs
0 1 S1350‑p yDsFLMysDDVLRsP
6 4 S1356‑p ysDDVLRsPSGsQRP
4 4 S1360‑p VLRsPSGsQRPsVSD
5 4 S1364‑p PSGsQRPsVSDDTGC
0 1 S1403‑p LIPRLSAsSGRSSDA
0 1 S1428‑p GAGGKGGsLPRSAtP
0 1 T1434‑p GsLPRSAtPGPPGEH
0 6 S1454‑p MDFAFPGstNsLHRM
1 1 T1455‑p DFAFPGstNsLHRMT
1 11 S1457‑p AFPGstNsLHRMTTT
0 1 S1465‑p LHRMTTTsAAAyGtH
0 67 Y1469‑p TTTsAAAyGtHLsPH
0 25 T1471‑p TsAAAyGtHLsPHVP
0 72 S1474‑p AAyGtHLsPHVPHRV
0 24 S1483‑p HVPHRVLstsstLtR
0 4 T1484‑p VPHRVLstsstLtRD
0 10 S1485‑p PHRVLstsstLtRDy
0 10 S1486‑p HRVLstsstLtRDyN
0 10 T1487‑p RVLstsstLtRDyNs
0 3 T1489‑p LstsstLtRDyNsLt
2 61 Y1492‑p sstLtRDyNsLtRsE
2 39 S1494‑p tLtRDyNsLtRsEHs
0 8 T1496‑p tRDyNsLtRsEHsHs
0 10 S1498‑p DyNsLtRsEHsHstt
0 3 S1501‑p sLtRsEHsHsttLPR
0 1 S1503‑p tRsEHsHsttLPRDy
0 6 T1504‑p RsEHsHsttLPRDys
0 4 T1505‑p sEHsHsttLPRDyst
4 161 Y1510‑p sttLPRDystLtsVs
0 6 S1511‑p ttLPRDystLtsVss
0 9 T1512‑p tLPRDystLtsVssH
0 4 T1514‑p PRDystLtsVssHDs
0 9 S1515‑p RDystLtsVssHDsR
0 7 S1517‑p ystLtsVssHDsRLt
1 28 S1518‑p stLtsVssHDsRLtA
0 1 - gap
0 1 S1521‑p tsVssHDsRLtAGVP
0 1 T1524‑p ssHDsRLtAGVPDtP
0 12 T1530‑p LtAGVPDtPTRLVFs
0 1 S1537‑p tPTRLVFsALGPTSL
5 1 Y1564‑p LQGYSVEyQLLNGGE
0 5 S1595‑p EDLLPNHsyVFRVRA
1 8 Y1596‑p DLLPNHsyVFRVRAQ
0 13 S1604‑p VFRVRAQsQEGWGRE
0 1 S1653‑p PLVFTALsPDSLQLS
0 2 Y1674‑p PNGDIVGyLVTCEMA
0 1 T1688‑p AQGGGPAtAFRVDGD
0 3 S1696‑p AFRVDGDsPESRLTV
0 1 S1707‑p RLTVPGLsENVPYKF
1 0 Y1712 GLsENVPYKFKVQAR
0 1 T1720‑p KFKVQARttEGFGPE
0 1 T1721‑p FKVQARttEGFGPER
0 8 S1758‑p LFQHPLQsEyssItt
0 40 Y1760‑p QHPLQsEyssItttH
0 3 S1761‑p HPLQsEyssItttHT
0 2 S1762‑p PLQsEyssItttHTS
0 1 T1764‑p QsEyssItttHTSAt
0 2 T1765‑p sEyssItttHTSAtE
0 2 T1766‑p EyssItttHTSAtEP
0 1 T1771‑p tttHTSAtEPFLVDG
0 9 S1791‑p QHLEAGGsLtRHVtQ
0 4 T1793‑p LEAGGsLtRHVtQEF
1 17 T1797‑p GsLtRHVtQEFVSRt
0 1 T1804‑p tQEFVSRtLttSGTL
2 5 T1806‑p EFVSRtLttSGTLST
0 3 T1807‑p FVSRtLttSGTLSTH
  ITGB4 iso2  
S7 _MAGPRPSPWARLLL
S21 LAALISVSLSGTLAN
Y50 RVDKDCAYCTDEMFR
S102 TLRRSQMSPQGLRVR
T164 ARVLSQLTSDYTIGF
S165 RVLSQLTSDYTIGFG
Y167 LSQLTSDYTIGFGKF
K173 DYTIGFGKFVDKVSV
K177 GFGKFVDKVSVPQTD
K191 DMRPEKLKEPWPNSD
T210 FKNVISLTEDVDEFR
K219 DVDEFRNKLQGERIS
S368 EAFNRIRSNLDIRAL
S377 LDIRALDSPRGLRTE
T383 DSPRGLRTEVTSKMF
S387 GLRTEVTSKMFQKTR
K388 LRTEVTSKMFQKTRT
S397 FQKTRTGSFHIRRGE
Y408 RRGEVGIYQVQLRAL
K437 QKGNIHLKPSFSDGL
K437 QKGNIHLKPSFSDGL
K654 TCEECNFKVKMVDEL
K656 EECNFKVKMVDELKR
K662 VKMVDELKRAEEVVV
T681 RDEDDDCTYSYTMEG
K758 RGHMVGFKEDHYMLR
Y762 VGFKEDHYMLRENLM
S771 LRENLMASDHLDTPM
T776 MASDHLDTPMLRSGN
K785 MLRSGNLKGRDVVRW
S809 GFATHAASINPTELV
S821 ELVPYGLSLRLARLC
T829 LRLARLCTENLLKPD
K834 LCTENLLKPDTRECA
T837 ENLLKPDTRECAQLR
Y855‑p EENLNEVyRQISGVH
T886 QDHTIVDTVLMAPRS
K895 LMAPRSAKPALLKLT
K904 ALLKLTEKQVEQRAF
K915 QRAFHDLKVAPGyYT
Y920‑p DLKVAPGyYTLTADQ
Y921 LKVAPGyYTLTADQD
T922 KVAPGyYTLTADQDA
K958 RPEDDDEKQLLVEAI
T973 DVPAGTATLGRRLVN
T982 GRRLVNITIIKEQAR
S1000 SFEQPEFSVSRGDQV
K1021 RRVLDGGKSQVSYRT
Y1039 TAQGNRDYIPVEGEL
K1060 AWKELQVKLLELQEV
S1069‑p LELQEVDsLLRGRQV
S1084 RRFHVQLSNPKFGAH
S1097 AHLGQPHSTTIIIRD
T1098 HLGQPHSTTIIIRDP
T1099 LGQPHSTTIIIRDPD
S1119 FTSQMLSSQPPPHGD
S1140 PNAKAAGSRKIHFNW
S1167 KYWIQGDSESEAHLL
Y1187 SVELTNLYPyCDYEM
Y1189‑p ELTNLYPyCDYEMKV
Y1207‑p GAQGEGPySSLVSCR
S1208 AQGEGPySSLVSCRT
S1209 QGEGPySSLVSCRTH
T1246 SWAEPAETNGEITAY
Y1257 ITAYEVCYGLVNDDN
Y1294 NLRESQPYRYTVKAR
T1297 ESQPYRYTVKARNGA
T1318 EAIINLATQPKRPMS
S1325 TQPKRPMSIPIIPDI
Y1343‑p DAQSGEDyDSFLMyS
S1345 QSGEDyDSFLMySDD
Y1349‑p DyDSFLMySDDVLRs
S1350 yDSFLMySDDVLRsP
S1356‑p ySDDVLRsPSGsQRP
S1360‑p VLRsPSGsQRPsVSD
S1364‑p PSGsQRPsVSDDTEH
- gap
- gap
- gap
S1384 MDFAFPGStNsLHRM
T1385‑p DFAFPGStNsLHRMT
S1387‑p AFPGStNsLHRMTTT
S1395 LHRMTTTSAAAyGTH
Y1399‑p TTTSAAAyGTHLsPH
T1401 TSAAAyGTHLsPHVP
S1404‑p AAyGTHLsPHVPHRV
S1413‑p HVPHRVLsTsstLTR
T1414 VPHRVLsTsstLTRD
S1415‑p PHRVLsTsstLTRDy
S1416‑p HRVLsTsstLTRDyN
T1417‑p RVLsTsstLTRDyNs
T1419 LsTsstLTRDyNsLT
Y1422‑p sstLTRDyNsLTRSE
S1424‑p tLTRDyNsLTRSEHS
T1426 TRDyNsLTRSEHSHS
S1428 DyNsLTRSEHSHSTT
S1431 sLTRSEHSHSTTLPR
S1433 TRSEHSHSTTLPRDy
T1434 RSEHSHSTTLPRDyS
T1435 SEHSHSTTLPRDyST
Y1440‑p STTLPRDySTLTSVS
S1441 TTLPRDySTLTSVSs
T1442 TLPRDySTLTSVSsH
T1444 PRDySTLTSVSsHDS
S1445 RDySTLTSVSsHDSR
S1447 ySTLTSVSsHDSRLT
S1448‑p STLTSVSsHDSRLTA
- gap
S1451 TSVSsHDSRLTAGVP
T1454 SsHDSRLTAGVPDTP
T1460 LTAGVPDTPTRLVFS
S1467 TPTRLVFSALGPTSL
Y1494‑p LQGYSVEyQLLNGGE
S1525 EDLLPNHSyVFRVRA
Y1526‑p DLLPNHSyVFRVRAQ
S1534‑p VFRVRAQsQEGWGRE
S1583 PLVFTALSPDSLQLS
Y1604 PNGDIVGYLVTCEMA
T1618 AQGGGPATAFRVDGD
S1626 AFRVDGDSPESRLTV
S1637 RLTVPGLSENVPyKF
Y1642‑p GLSENVPyKFKVQAR
T1650 KFKVQARTTEGFGPE
T1651 FKVQARTTEGFGPER
S1688 LFQHPLQSEySSITT
Y1690‑p QHPLQSEySSITTTH
S1691 HPLQSEySSITTTHT
S1692 PLQSEySSITTTHTS
T1694 QSEySSITTTHTSAT
T1695 SEySSITTTHTSATE
T1696 EySSITTTHTSATEP
T1701 TTTHTSATEPFLVDG
S1721 QHLEAGGSLTRHVtQ
T1723 LEAGGSLTRHVtQEF
T1727‑p GSLTRHVtQEFVSRT
T1734 tQEFVSRTLttSGTL
T1736‑p EFVSRTLttSGTLST
T1737‑p FVSRTLttSGTLSTH
  ITGB4 iso3  
S7 _MAGPRPSPWARLLL
S21 LAALISVSLSGTLAN
Y50 RVDKDCAYCTDEMFR
S102 TLRRSQMSPQGLRVR
T164 ARVLSQLTSDYTIGF
S165 RVLSQLTSDYTIGFG
Y167 LSQLTSDYTIGFGKF
K173 DYTIGFGKFVDKVSV
K177 GFGKFVDKVSVPQTD
K191 DMRPEKLKEPWPNSD
T210 FKNVISLTEDVDEFR
K219 DVDEFRNKLQGERIS
S368 EAFNRIRSNLDIRAL
S377 LDIRALDSPRGLRTE
T383 DSPRGLRTEVTSKMF
S387 GLRTEVTSKMFQKTR
K388 LRTEVTSKMFQKTRT
S397 FQKTRTGSFHIRRGE
Y408 RRGEVGIYQVQLRAL
K437 QKGNIHLKPSFSDGL
K437 QKGNIHLKPSFSDGL
K654 TCEECNFKVKMVDEL
K656 EECNFKVKMVDELKR
K662 VKMVDELKRAEEVVV
T681 RDEDDDCTYSYTMEG
K758 RGHMVGFKEDHYMLR
Y762 VGFKEDHYMLRENLM
S771 LRENLMASDHLDTPM
T776 MASDHLDTPMLRSGN
K785 MLRSGNLKGRDVVRW
S809 GFATHAASINPTELV
S821 ELVPYGLSLRLARLC
T829 LRLARLCTENLLKPD
K834 LCTENLLKPDTRECA
T837 ENLLKPDTRECAQLR
Y855 EENLNEVYRQISGVH
T886 QDHTIVDTVLMAPRS
K895 LMAPRSAKPALLKLT
K904 ALLKLTEKQVEQRAF
K915 QRAFHDLKVAPGYYT
Y920 DLKVAPGYYTLTADQ
Y921 LKVAPGYYTLTADQD
T922 KVAPGYYTLTADQDA
K958 RPEDDDEKQLLVEAI
T973 DVPAGTATLGRRLVN
T982 GRRLVNITIIKEQAR
S1000 SFEQPEFSVSRGDQV
K1021 RRVLDGGKSQVSYRT
Y1039 TAQGNRDYIPVEGEL
K1060 AWKELQVKLLELQEV
S1069 LELQEVDSLLRGRQV
S1084 RRFHVQLSNPKFGAH
S1097 AHLGQPHSTTIIIRD
T1098 HLGQPHSTTIIIRDP
T1099 LGQPHSTTIIIRDPD
S1119 FTSQMLSSQPPPHGD
S1140 PNAKAAGSRKIHFNW
S1167 KYWIQGDSESEAHLL
Y1187 SVELTNLYPYCDYEM
Y1189 ELTNLYPYCDYEMKV
Y1207 GAQGEGPYSSLVSCR
S1208 AQGEGPYSSLVSCRT
S1209 QGEGPYSSLVSCRTH
T1246 SWAEPAETNGEITAY
Y1257 ITAYEVCYGLVNDDN
Y1294 NLRESQPYRYTVKAR
T1297 ESQPYRYTVKARNGA
T1318 EAIINLATQPKRPMS
S1325 TQPKRPMSIPIIPDI
Y1343 DAQSGEDYDSFLMYS
S1345 QSGEDYDSFLMYSDD
Y1349 DYDSFLMYSDDVLRs
S1350 YDSFLMYSDDVLRsP
S1356‑p YSDDVLRsPSGsQRP
S1360‑p VLRsPSGsQRPsVSD
S1364‑p PSGsQRPsVSDDTEH
- gap
- gap
- gap
S1384 MDFAFPGSTNSLHRM
T1385 DFAFPGSTNSLHRMT
S1387 AFPGSTNSLHRMTTT
S1395 LHRMTTTSAAAYGTH
Y1399 TTTSAAAYGTHLSPH
T1401 TSAAAYGTHLSPHVP
S1404 AAYGTHLSPHVPHRV
S1413 HVPHRVLSTSSTLTR
T1414 VPHRVLSTSSTLTRD
S1415 PHRVLSTSSTLTRDY
S1416 HRVLSTSSTLTRDYN
T1417 RVLSTSSTLTRDYNS
T1419 LSTSSTLTRDYNSLT
Y1422 SSTLTRDYNSLTRSE
S1424 TLTRDYNSLTRSEHS
T1426 TRDYNSLTRSEHSHS
S1428 DYNSLTRSEHSHSTT
S1431 SLTRSEHSHSTTLPR
S1433 TRSEHSHSTTLPRDy
T1434 RSEHSHSTTLPRDys
T1435 SEHSHSTTLPRDysT
Y1440‑p STTLPRDysTLTSVS
S1441‑p TTLPRDysTLTSVSS
T1442 TLPRDysTLTSVSSH
T1444 PRDysTLTSVSSHGL
S1445 RDysTLTSVSSHGLP
S1447 ysTLTSVSSHGLPPI
S1448 sTLTSVSSHGLPPIW
S1482 QMKGFPPSRGPRDSI
S1504 APSWGPDSRLTAGVP
T1507 WGPDSRLTAGVPDTP
T1513 LTAGVPDTPTRLVFS
S1520 TPTRLVFSALGPTSL
Y1547 LQGYSVEYQLLNGGE
S1578 EDLLPNHSYVFRVRA
Y1579 DLLPNHSYVFRVRAQ
S1587 VFRVRAQSQEGWGRE
S1636 PLVFTALSPDSLQLS
Y1657 PNGDIVGYLVTCEMA
T1671 AQGGGPATAFRVDGD
S1679 AFRVDGDSPESRLTV
S1690 RLTVPGLSENVPYKF
Y1695 GLSENVPYKFKVQAR
T1703 KFKVQARTTEGFGPE
T1704 FKVQARTTEGFGPER
S1741 LFQHPLQSEYSSITT
Y1743 QHPLQSEYSSITTTH
S1744 HPLQSEYSSITTTHT
S1745 PLQSEYSSITTTHTS
T1747 QSEYSSITTTHTSAT
T1748 SEYSSITTTHTSATE
T1749 EYSSITTTHTSATEP
T1754 TTTHTSATEPFLVDG
S1774 QHLEAGGSLTRHVTQ
T1776 LEAGGSLTRHVTQEF
T1780 GSLTRHVTQEFVSRT
T1787 TQEFVSRTLTTSGTL
T1789 EFVSRTLTTSGTLST
T1790 FVSRTLTTSGTLSTH
  mouse

► Hide Isoforms
 
S7 _MAGPCCSPWVKLLL
S22 LAAMLSASLPGDLAN
Y51 RVDKSCAYCTDELFK
S103 SLHRSQVSPQGLQVR
T165 AKILRQLTSDYTIGF
S166 KILRQLTSDYTIGFG
Y168 LRQLTSDYTIGFGKF
K174 DYTIGFGKFVDKVSV
K178 GFGKFVDKVSVPQTD
K192 DMRPEKLKEPWPNSD
T211 FKNVISLTENVEEFW
K220 NVEEFWNKLQGERIS
S369 EAFYRIRSNLDIRAL
S378 LDIRALDSPRGLRTE
T384 DSPRGLRTEVTSDTL
S388 GLRTEVTSDTLQKTE
D389 LRTEVTSDTLQKTET
S398 LQKTETGSFHIKRGE
Y409 KRGEVGTYNVHLRAV
K439 QGGNIHLKPSFSDGL
K439 QGGNIHLKPSFSDGL
K656 ACDDCPFKVKMVDEL
K658 DDCPFKVKMVDELKK
K664 VKMVDELKKAEEVVE
T683 RDEDDDCTYSYNVEG
K760 RGHMVGFKEDHYMLR
Y764 VGFKEDHYMLRENLM
S773 LRENLMASDHLDTPM
T778 MASDHLDTPMLRSGN
K787 MLRSGNLKGRDTVRW
S811 GFATHAASTSPTELV
S823 ELVPYGLSLRLGRLC
T831 LRLGRLCTENLMKPG
K836 LCTENLMKPGTRECD
T839 ENLMKPGTRECDQLR
Y857 EENLNEVYRQVSGAH
T888 QDHTIVDTVLLAPRS
K897 LLAPRSAKQMLLKLT
K906 MLLKLTEKQVEQGSF
K917 QGSFHELKVAPGYYT
Y922 ELKVAPGYYTVTAEQ
Y923 LKVAPGYYTVTAEQD
T924 KVAPGYYTVTAEQDA
K960 RPEDDDEKQLLVEAI
T975 DVPVGTATLGRRLVN
T984 GRRLVNITIIKEQAS
S1002 SFEQPEYSVSRGDQV
K1023 RHILDNGKSQVSYST
Y1041 TAHGHRDYVPVEGEL
K1062 TWKELQVKLLELQEV
S1071‑p LELQEVDsLLRGRQV
S1086 RRFQVQLSNPKFGAR
T1099 ARLGQPSTTTVILGE
T1100 RLGQPSTTTVILGEH
T1101 LGQPSTTTVILGEHD
S1121 LINQTLSSPPPPHGD
S1142 PNAKAAGSRKIHFNW
S1169 KYWIQGDSESEAHLL
Y1189 SVELTNLYPYCDYEM
Y1191 ELTNLYPYCDYEMKV
Y1209‑p GAQGEGPySsLVSCR
S1210 AQGEGPySsLVSCRT
S1211‑p QGEGPySsLVSCRTH
T1248‑p SWAEPAEtNGEITAY
Y1259 ITAYEVCYGLVNEDN
Y1296 NLRESQPYRYTVKAR
T1299 ESQPYRYTVKARNGA
T1320 EAIINLATQPKRPMS
S1327 TQPKRPMSIPIIPDI
Y1345 DAQGGEDYENFLMYS
N1347 QGGEDYENFLMYSDD
Y1351 DYENFLMYSDDVLRS
S1352 YENFLMYSDDVLRSP
S1358 YSDDVLRSPASSQRP
S1362 VLRSPASSQRPSVSD
S1366 PASSQRPSVSDDTGC
S1405 LIPRLSASSGRSDED
S1424 GGVEGEGSGWIRGAT
T1431 SGWIRGATPRPPGEH
S1451 MDFAYPGSANSLHRM
A1452 DFAYPGSANSLHRMT
S1454 AYPGSANSLHRMTAA
N1462 LHRMTAANVAYGTHL
Y1465 MTAANVAYGTHLSPH
T1467 AANVAYGTHLSPHLS
S1470 VAYGTHLSPHLSHRV
S1479‑p HLSHRVLsTSSTLTR
T1480 LSHRVLsTSSTLTRD
S1481 SHRVLsTSSTLTRDY
S1482 HRVLsTSSTLTRDYH
T1483 RVLsTSSTLTRDYHS
T1485 LsTSSTLTRDYHSLT
Y1488 SSTLTRDYHSLTRTE
S1490 TLTRDYHSLTRTEHS
T1492 TRDYHSLTRTEHSHS
T1494 DYHSLTRTEHSHSGT
S1497 SLTRTEHSHSGTLPR
S1499 TRTEHSHSGTLPRDY
G1500 RTEHSHSGTLPRDYs
T1501 TEHSHSGTLPRDYsT
Y1506 SGTLPRDYsTLTSLS
S1507‑p GTLPRDYsTLTSLSS
T1508 TLPRDYsTLTSLSSQ
T1510 PRDYsTLTSLSSQDS
S1511 RDYsTLTSLSSQDSR
S1513 YsTLTSLSSQDSRGA
S1514 sTLTSLSSQDSRGAV
- gap
S1517 TSLSSQDSRGAVGVP
A1520 SSQDSRGAVGVPDTP
T1526 GAVGVPDTPTRLVFS
S1533 TPTRLVFSALGPTSL
Y1560 LLGYSVEYQLLNGGE
S1591 EDLLPNHSYVFRVRA
Y1592 DLLPNHSYVFRVRAQ
S1600‑p VFRVRAQsQEGWGRE
S1649 PLVFTALSPDSLQLS
Y1670 PNGDILGYLVTCEMA
R1684 AQGGAPARTFRVDGD
N1692 TFRVDGDNPESRLTV
S1703 RLTVPGLSENVPYKF
Y1708 GLSENVPYKFKVQAR
T1716 KFKVQARTTEGFGPE
T1717 FKVQARTTEGFGPER
S1754 LFQNPVQSEFSSVTS
F1756 QNPVQSEFSSVTSTH
S1757 NPVQSEFSSVTSTHS
S1758 PVQSEFSSVTSTHST
T1760 QSEFSSVTSTHSTTT
S1761 SEFSSVTSTHSTTTE
T1762 EFSSVTSTHSTTTEP
T1767 TSTHSTTTEPFLMDG
S1787 QRLEAGGSLTRHVTQ
T1789 LEAGGSLTRHVTQEF
T1793 GSLTRHVTQEFVTRT
T1800 TQEFVTRTLTASGSL
T1802 EFVTRTLTASGSLST
A1803 FVTRTLTASGSLSTH
  ITGB4 iso2  
S7 _MAGPCCSPWVKLLL
S22 LAAMLSASLPGDLAN
Y51 RVDKSCAYCTDELFK
S103 SLHRSQVSPQGLQVR
T165 AKILRQLTSDYTIGF
S166 KILRQLTSDYTIGFG
Y168 LRQLTSDYTIGFGKF
K174 DYTIGFGKFVDKVSV
K178 GFGKFVDKVSVPQTD
K192 DMRPEKLKEPWPNSD
T211 FKNVISLTENVEEFW
K220 NVEEFWNKLQGERIS
S369 EAFYRIRSNLDIRAL
S378 LDIRALDSPRGLRTE
T384 DSPRGLRTEVTSDTL
S388 GLRTEVTSDTLQKTE
D389 LRTEVTSDTLQKTET
S398 LQKTETGSFHIKRGE
Y409 KRGEVGTYNVHLRAV
K439 QGGNIHLKPSFSDGL
K439 QGGNIHLKPSFSDGL
K656‑ac ACDDCPFkVkMVDEL
K658‑ac DDCPFkVkMVDELKK
K664 VkMVDELKKAEEVVE
T683 RDEDDDCTYSYNVEG
K760 RGHMVGFKEDHYMLR
Y764 VGFKEDHYMLRENLM
S773 LRENLMASDHLDTPM
T778 MASDHLDTPMLRSGN
K787 MLRSGNLKGRDTVRW
S811 GFATHAASTSPTELV
S823 ELVPYGLSLRLGRLC
T831 LRLGRLCTENLMKPG
K836 LCTENLMKPGTRECD
T839 ENLMKPGTRECDQLR
Y857 EENLNEVYRQVSGAH
T888 QDHTIVDTVLLAPRS
K897 LLAPRSAKQMLLKLT
K906 MLLKLTEKQVEQGSF
K917 QGSFHELKVAPGYYT
Y922 ELKVAPGYYTVTAEQ
Y923 LKVAPGYYTVTAEQD
T924 KVAPGYYTVTAEQDA
K960 RPEDDDEKQLLVEAI
T975 DVPVGTATLGRRLVN
T984 GRRLVNITIIKEQAS
S1002 SFEQPEYSVSRGDQV
K1023 RHILDNGKSQVSYST
Y1041 TAHGHRDYVPVEGEL
K1062 TWKELQVKLLELQEV
S1071‑p LELQEVDsLLRGRQV
S1086 RRFQVQLSNPKFGAR
T1099 ARLGQPSTTTVILGE
T1100 RLGQPSTTTVILGEH
T1101 LGQPSTTTVILGEHD
S1121 LINQTLSSPPPPHGD
S1142 PNAKAAGSRKIHFNW
S1169 KYWIQGDSESEAHLL
Y1189 SVELTNLYPYCDYEM
Y1191 ELTNLYPYCDYEMKV
Y1209 GAQGEGPYSSLVSCR
S1210 AQGEGPYSSLVSCRT
S1211 QGEGPYSSLVSCRTH
T1248 SWAEPAETNGEITAY
Y1259 ITAYEVCYGLVNEDN
Y1296‑p NLRESQPyRYTVKAR
T1299 ESQPyRYTVKARNGA
T1320 EAIINLATQPKRPMS
S1327 TQPKRPMSIPIIPDI
Y1345 DAQGGEDYENFLMYS
N1347 QGGEDYENFLMYSDD
Y1351 DYENFLMYSDDVLRS
S1352 YENFLMYSDDVLRSP
S1358 YSDDVLRSPASSQRP
S1362 VLRSPASSQRPsVSD
S1366‑p PASSQRPsVSDDTEH
- gap
- gap
- gap
S1386‑p MDFAYPGsANsLHRM
A1387 DFAYPGsANsLHRMT
S1389‑p AYPGsANsLHRMTAA
N1397 LHRMTAANVAYGTHL
Y1400 MTAANVAYGTHLsPH
T1402 AANVAYGTHLsPHLS
S1405‑p VAYGTHLsPHLSHRV
S1414 HLSHRVLSTSSTLTR
T1415 LSHRVLSTSSTLTRD
S1416 SHRVLSTSSTLTRDY
S1417 HRVLSTSSTLTRDYH
T1418 RVLSTSSTLTRDYHS
T1420 LSTSSTLTRDYHSLT
Y1423 SSTLTRDYHSLTRTE
S1425 TLTRDYHSLTRTEHS
T1427 TRDYHSLTRTEHSHS
T1429 DYHSLTRTEHSHSGT
S1432 SLTRTEHSHSGTLPR
S1434 TRTEHSHSGTLPRDY
G1435 RTEHSHSGTLPRDYS
T1436 TEHSHSGTLPRDYST
Y1441 SGTLPRDYSTLTSLS
S1442 GTLPRDYSTLTSLSS
T1443 TLPRDYSTLTSLSSQ
T1445 PRDYSTLTSLSSQDS
S1446 RDYSTLTSLSSQDSR
S1448 YSTLTSLSSQDSRGA
S1449 STLTSLSSQDSRGAV
- gap
S1452 TSLSSQDSRGAVGVP
A1455 SSQDSRGAVGVPDTP
T1461 GAVGVPDTPTRLVFS
S1468 TPTRLVFSALGPTSL
Y1495 LLGYSVEYQLLNGGE
S1526 EDLLPNHSYVFRVRA
Y1527 DLLPNHSYVFRVRAQ
S1535 VFRVRAQSQEGWGRE
S1584 PLVFTALSPDSLQLS
Y1605 PNGDILGYLVTCEMA
R1619 AQGGAPARTFRVDGD
N1627 TFRVDGDNPESRLTV
S1638 RLTVPGLSENVPYKF
Y1643 GLSENVPYKFKVQAR
T1651 KFKVQARTTEGFGPE
T1652 FKVQARTTEGFGPER
S1689 LFQNPVQSEFSSVTS
F1691 QNPVQSEFSSVTSTH
S1692 NPVQSEFSSVTSTHS
S1693 PVQSEFSSVTSTHST
T1695 QSEFSSVTSTHSTTT
S1696 SEFSSVTSTHSTTTE
T1697 EFSSVTSTHSTTTEP
T1702 TSTHSTTTEPFLMDG
S1722‑p QRLEAGGsLTRHVTQ
T1724 LEAGGsLTRHVTQEF
T1728 GsLTRHVTQEFVTRT
T1735 TQEFVTRTLTASGSL
T1737 EFVTRTLTASGSLST
A1738 FVTRTLTASGSLSTH
  ITGB4 iso3  
S7 _MAGPCCSPWVKLLL
S22 LAAMLSASLPGDLAN
Y51 RVDKSCAYCTDELFK
S103 SLHRSQVSPQGLQVR
T165 AKILRQLTSDYTIGF
S166 KILRQLTSDYTIGFG
Y168 LRQLTSDYTIGFGKF
K174