a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2. Note: This description may include information from UniProtKB.
Molecular Function: DNA binding; protein binding; protein domain specific binding; transcription factor activity
Biological Process: cell redox homeostasis; cellular response to glucose starvation; inflammatory response; positive regulation of blood coagulation; positive regulation of glucose import; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; regulation of embryonic development; transcription from RNA polymerase II promoter; unfolded protein response
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.