a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis
Cellular Component: cell surface; external side of plasma membrane; focal adhesion; integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: heparan sulfate proteoglycan binding; heparin binding; hydrolase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity
Biological Process: activation of MAPK activity; B cell differentiation; B cell proliferation; B cell receptor signaling pathway; bone marrow development; defense response to virus; dephosphorylation; hemopoietic progenitor cell differentiation; heterotypic cell-cell adhesion; immunoglobulin biosynthetic process; leukocyte adhesion; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein amino acid autophosphorylation; negative regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of antigen receptor-mediated signaling pathway; positive regulation of B cell proliferation; positive regulation of gamma-delta T cell differentiation; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of isotype switching to IgG isotypes; positive regulation of MAPKKK cascade; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive thymic T cell selection; protein amino acid dephosphorylation; regulation of B cell differentiation; regulation of B cell receptor signaling pathway; regulation of cell cycle; regulation of humoral immune response mediated by circulating immunoglobulin; release of sequestered calcium ion into cytosol; response to gamma radiation; stem cell development; substrate-bound cell migration, cell release from substrate; T cell differentiation; T cell proliferation; T cell receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.