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Protein Page:
CD45 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD45 a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis
Cellular Component: cell surface; external side of plasma membrane; focal adhesion; integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: heparan sulfate proteoglycan binding; heparin binding; hydrolase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity
Biological Process: activation of MAPK activity; B cell differentiation; B cell proliferation; B cell receptor signaling pathway; bone marrow development; defense response to virus; dephosphorylation; hemopoietic progenitor cell differentiation; heterotypic cell-cell adhesion; immunoglobulin biosynthetic process; leukocyte adhesion; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein amino acid autophosphorylation; negative regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of antigen receptor-mediated signaling pathway; positive regulation of B cell proliferation; positive regulation of gamma-delta T cell differentiation; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of isotype switching to IgG isotypes; positive regulation of MAPKKK cascade; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive thymic T cell selection; protein amino acid dephosphorylation; regulation of B cell differentiation; regulation of B cell receptor signaling pathway; regulation of cell cycle; regulation of humoral immune response mediated by circulating immunoglobulin; release of sequestered calcium ion into cytosol; response to gamma radiation; stem cell development; substrate-bound cell migration, cell release from substrate; T cell differentiation; T cell proliferation; T cell receptor signaling pathway
Reference #:  P06800 (UniProtKB)
Alt. Names/Synonyms: B220; Cd45; CD45R; L-CA; Leukocyte common antigen; loc; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200
Gene Symbols: Ptprc
Molecular weight: 144,604 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Select Structure to View Below

CD45

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S988‑p, S991‑p, S992‑p, S996‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 N253 EECSQIKNISVSNDS
0 1 N426 EKCKSLPNNVTSFEV
0 1 Y442 SLKPYKYYEVSLLAY
0 1 S445 PYKYYEVSLLAYVNG
0 1 Y533 FYVDNLYYSTDYEFL
0 1 Y537 NLYYSTDYEFLVSFH
0 1 Y548 VSFHNGVYEGDSVIR
0 1 K630 DILLETYKRKIADEG
0 1 K630 DILLETYKRKIADEG
0 7 S646 LFLAEFQSIPRVFsK
0 4 S652‑p QSIPRVFsKFPIKDA
0 4 K653 SIPRVFsKFPIKDAR
0 1 K657 VFsKFPIKDARKPHN
0 1 K657 VFsKFPIKDARKPHN
0 19 Y670‑p HNQNKNRyVDILPYD
0 2 Y676 RyVDILPYDYNRVEL
0 1 Y678 VDILPYDYNRVELSE
0 4 Y694 NGDAGSTYINASYID
0 5 Y699 STYINASYIDGFkEP
0 9 K704‑ub ASYIDGFkEPRKYIA
0 11 Y752 NRNKCAEYWPSMEEG
0 1 T769 AFKDIVVTINDHkRC
0 4 K774‑ub VVTINDHkRCPDYII
0 6 Y779 DHkRCPDYIIQKLNV
0 1 K789 QKLNVAHKKEKATGR
0 1 T847 CSAGVGRTGTYIGID
0 1 T849 AGVGRTGTYIGIDAM
0 1 Y850 GVGRTGTYIGIDAML
0 1 Y869 AEGKVDVYGYVVKLR
0 1 Y889 MVQVEAQYILIHQAL
0 1 C915 NLSELHSCLHNMKKR
0 1 K921 SCLHNMKKRDPPSDP
0 1 S926 MKKRDPPSDPSPLEA
0 3 Y935‑p PSPLEAEyQRLPSYR
0 3 S940 AEyQRLPSYRSWRTQ
0 2 K956 IGNQEENKkkNRNsN
0 2 K957‑ub GNQEENKkkNRNsNV
0 2 K958‑ub NQEENKkkNRNsNVV
0 117 S962‑p NKkkNRNsNVVPYDF
0 14 Y967 RNsNVVPYDFNRVPL
0 114 F969 sNVVPYDFNRVPLKH
0 5 S981 LKHELEMSKESEPEs
0 3 S984 ELEMSKESEPEsDEs
1 3 S988‑p SKESEPEsDEssDDD
1 4 S991‑p SEPEsDEssDDDsDS
1 5 S992‑p EPEsDEssDDDsDSE
1 3 S996‑p DEssDDDsDSEETSK
0 1 K1078 GDMEVEMKDTNRASA
0 1 R1082 VEMKDTNRASAYTLR
0 2 R1082 VEMKDTNRASAYTLR
0 1 K1113‑ub QYQCTTWkGEELPAE
0 1 S1139‑p KQKLPKAsPEGMKYH
1 1 Y1204 VVCSYEQYQFLYDII
0 1 Y1208 YEQYQFLYDIIASIY
0 4 T1225‑p QNGQVKKtNsQDKIE
0 8 S1227‑p GQVKKtNsQDKIEFH
0 1 K1230 KKtNsQDKIEFHNEV
0 1 K1255 RPDGPLNKAQEDSRG
0 4 T1265‑p EDSRGVGtPEPtNsA
0 1 P1266 DSRGVGtPEPtNsAE
0 1 T1269‑p GVGtPEPtNsAEEPE
0 1 S1271‑p GtPEPtNsAEEPEHA
0 1 A1272 tPEPtNsAEEPEHAA
0 1 A1278 sAEEPEHAANGsAsP
0 1 S1282‑p PEHAANGsAsPAPTQ
0 15 S1284‑p HAANGsAsPAPTQSS
  human

 
S278‑p LTECKNAsVSISHNS
K437‑ac KDCLNLDkNLIKYDL
Y453‑p NLKPYTKyVLsLHAY
S456‑p PYTKyVLsLHAYIIA
Y544‑p FRVKDLQySTDyTFK
Y548‑p DLQySTDyTFKAYFH
Y559‑p AYFHNGDyPGEPFIL
K641 DILLETYKRKIADEG
K641‑ub DILLETYkRKIADEG
S657‑p LFLAEFQsIPRVFsk
S663‑p QsIPRVFskFPIkEA
K664‑ub sIPRVFskFPIkEAR
K668 VFskFPIKEARKPFN
K668‑ub VFskFPIkEARKPFN
Y681‑p FNQNKNRyVDILPyD
Y687‑p RyVDILPyDyNRVEL
Y689‑p VDILPyDyNRVELSE
Y705‑p NGDAGSNyINASyID
Y710‑p SNyINASyIDGFkEP
K715‑ub ASyIDGFkEPRKYIA
Y763‑p NRNKCAEyWPSMEEG
K780‑ub AFGDVVVkINQHKRC
K785 VVkINQHKRCPDyII
Y790‑p QHKRCPDyIIQKLNI
K800‑ub QKLNIVNkKEKATGR
T858‑p CSAGVGRtGtyIGID
T860‑p AGVGRtGtyIGIDAM
Y861‑p GVGRtGtyIGIDAML
Y880‑p AENKVDVyGYVVKLR
Y900‑p MVQVEAQyILIHQAL
Y926‑p NLSELHPyLHNMKkR
K932‑ub PyLHNMKkRDPPsEP
S937‑p MKkRDPPsEPSPLEA
F946 PSPLEAEFQRLPsYR
S951‑p AEFQRLPsYRSWRTQ
K967‑ub IGNQEENkSKNRNsN
S968 GNQEENkSKNRNsNV
K969 NQEENkSKNRNsNVI
S973‑p NkSKNRNsNVIPyDy
Y978‑p RNsNVIPyDyNRVPL
Y980‑p sNVIPyDyNRVPLKH
S992‑p LKHELEMsKEsEHDs
S995‑p ELEMsKEsEHDsDEs
S999‑p sKEsEHDsDEssDDD
S1002‑p sEHDsDEssDDDsDS
S1003‑p EHDsDEssDDDsDSE
S1007‑p DEssDDDsDSEEPSK
K1089 GDIEVDLKDTDkSST
K1093‑ac VDLKDTDkSSTYTLR
K1093‑ub VDLKDTDkSSTYTLR
S1124 QYQYTNWSVEQLPAE
S1151 QKLPQKNSSEGNKHH
Y1216‑p MVSTFEQyQFLyDVI
Y1220‑p FEQyQFLyDVIASTY
N1237 QNGQVKKNNHQEDkI
H1239 GQVKKNNHQEDkIEF
K1243‑ub KNNHQEDkIEFDNEV
K1268‑ub NPLGAPEkLPEAKEQ
G1278 EAKEQAEGsEPTSGt
S1279‑p AKEQAEGsEPTSGtE
T1282 QAEGsEPTSGtEGPE
G1284 EGsEPTSGtEGPEHs
T1285‑p GsEPTSGtEGPEHsV
S1291‑p GtEGPEHsVNGPAsP
P1295 PEHsVNGPAsPALNQ
S1297‑p HsVNGPAsPALNQGS
  rat

 
N245 LPECSQKNVTLSNGS
N408 EKCENLANDVNSFEV
Y424 NLRPYTEYTVSLFAY
S427 PYTEYTVSLFAYVIG
Y515 FVVDNLYYSTDYEFL
Y519 NLYYSTDYEFLVYFY
Y530 VYFYNGEYLGDPEIK
K612‑ac DLLLETYkRKIADEG
K612 DLLLETYKRKIADEG
S628 LFLAEFQSIPRVFSK
S634 QSIPRVFSKFPIkDA
K635 SIPRVFSKFPIkDAR
K639‑ac VFSKFPIkDARKSQN
K639 VFSKFPIKDARKSQN
Y652‑p QNQNKNRyVDILPYD
Y658 RyVDILPYDYNRVEL
Y660 VDILPYDYNRVELSE
Y676 NGDAGSTYINASYID
Y681 STYINASYIDGFKEP
K686 ASYIDGFKEPRKYIA
Y734 NRNKCAEYWPCMEEG
T751 TFRDVVVTINDHKRC
K756 VVTINDHKRCPDYII
Y761 DHKRCPDYIIQKLSI
K771 QKLSIAHKKEKATGR
T829 CSAGVGRTGTYIGID
T831 AGVGRTGTYIGIDAM
Y832 GVGRTGTYIGIDAML
Y851 AEGKVDVYGYVVNLR
Y871 MVQVEAQYILIHQAL
C897 NLSELHSCLQNLKKR
K903 SCLQNLKKRDPPSDP
S908 LKKRDPPSDPSPLEA
Y917 PSPLEAEYQRLPSYR
S922 AEYQRLPSYRSWRTQ
K938 IGNQEENKKKNRSsN
K939 GNQEENKKKNRSsNV
K940 NQEENKKKNRSsNVV
S944‑p NKKKNRSsNVVPYDF
Y949 RSsNVVPYDFNRVPL
F951 sNVVPYDFNRVPLKH
S963‑p LKHELEMsKEsEAEs
S966‑p ELEMsKEsEAEsDEs
S970‑p sKEsEAEsDEssDED
S973‑p sEAEsDEssDEDsDS
S974‑p EAEsDEssDEDsDSE
S978‑p DEssDEDsDSEETSK
K1060‑ac GDMEVMLkDTNKSSA
K1064 VMLkDTNKSSAYILR
K1064 VMLkDTNKSSAYILR
K1095 QYQCTTWKGEELPAE
G1121 KQKLPKSGSEGMKYH
Y1186 MVGSFEQYQFLYDIM
Y1190 FEQYQFLYDIMASIY
A1207 QNGQVKKANsQDKIE
S1209‑p GQVKKANsQDKIEFH
K1212 KKANsQDKIEFHNEV
K1237 QPADPLNKAQEDSKE
A1247 EDSKEVGASEPASGS
S1248 DSKEVGASEPASGSE
A1251 EVGASEPASGSEEPE
G1253 GASEPASGSEEPEHS
S1254 ASEPASGSEEPEHSA
S1260 GSEEPEHSANGPMSP
P1264 PEHSANGPMSPALTP
S1266 HSANGPMSPALTPSS
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