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Protein Page:
NOTCH3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NOTCH3 Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Heterodimer of a C-terminal fragment N(TM) and a N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN. Ubiquitously expressed in fetal and adult tissues. Belongs to the NOTCH family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.2-p13.1
Cellular Component: actin cytoskeleton; cytoplasm; cytosol; endoplasmic reticulum membrane; extracellular region; Golgi membrane; nucleoplasm; plasma membrane; receptor complex
Molecular Function: protein binding
Biological Process: Notch receptor processing; Notch signaling pathway; transcription initiation from RNA polymerase II promoter
Disease: Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy; Lateral Meningocele Syndrome; Myofibromatosis, Infantile, 2
Reference #:  Q9UM47 (UniProtKB)
Alt. Names/Synonyms: CADASIL; CASIL; Neurogenic locus notch homolog protein 3; NOTC3; Notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch homolog 3 (Drosophila); NOTCH3
Gene Symbols: NOTCH3
Molecular weight: 243,631 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NOTCH3

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S84‑p QLEDPCHsGPCAGRG
0 1 S118‑p GFRGPDCsLPDPCLs
0 1 S125‑p sLPDPCLssPCAHGA
0 1 S126‑p LPDPCLssPCAHGAR
0 1 S135‑p CAHGARCsVGPDGRF
0 1 T211‑p SPCRNGGtCRQSGDL
0 1 Y529‑p CVDQPDGyECRCAEG
0 1 S1079 CPEGRTGSHCEQEVD
0 1 T1098 QPCQHGGTCRGYMGG
0 1 Y1197‑p RCTCPPGyTGLRCEA
0 2 S1672‑p ARRKREHstLWFPEG
0 1 T1673‑p RRKREHstLWFPEGF
0 2 S1681‑p LWFPEGFsLHkDVAS
0 1 K1684‑ub PEGFsLHkDVASGHK
1 0 K1691 kDVASGHKGRREPVG
1 0 K1730 DTECPEAKRLKVEEP
0 1 Y1849‑p ALHLAARyARADAAK
0 1 T1908‑p ARMADGStALILAAR
0 2 S2032‑p DQPSGPRsPPGPHGL
0 1 R2174‑m1 AVPLDWArLPPPAPP
  mouse

 
S85 QLEDPCHSGPCAGRG
S119 GFQGPDCSQPDPCVS
S126 SQPDPCVSRPCVHGA
R127 QPDPCVSRPCVHGAP
S136 CVHGAPCSVGPDGRF
T212 SPCRNGGTCRQSSDV
Y530 CVDQPDGYECRCAEG
S1080‑p CPEGRTGsHCEHEVD
T1099‑p QPCQHGGtCRGYMGG
Y1198 RCNCPPGYTGLHCEA
S1673 ARRKREHSTLWFPEG
T1674 RRKREHSTLWFPEGF
A1682 LWFPEGFALHKDIAA
K1685 PEGFALHKDIAAGHk
K1692‑ac KDIAAGHkGRREPVG
K1731‑ac DSECPEAkRLKVEEP
Y1850 ALHLAARYARADAAK
T1909 ARMADGSTALILAAR
S2033 DQPSGPRSPSGPHGL
R2174 AVPLDWARLPPPAPP
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