a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 18.104.22.168; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Molecular Function: chromatin binding; deacetylase activity; enzyme binding; histone deacetylase activity; NF-kappaB binding; nucleosomal DNA binding; protein binding; protein deacetylase activity; RNA binding; sequence-specific DNA binding; transcription factor binding
Biological Process: ATP-dependent chromatin remodeling; blood coagulation; chromatin remodeling; circadian regulation of gene expression; dendrite development; embryonic digit morphogenesis; epidermal cell differentiation; histone deacetylation; maintenance of chromatin silencing; negative regulation of apoptosis; negative regulation of MHC class II biosynthetic process; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent