a transcriptional regulator of the histone deacetylase family, subfamily 1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays a role in epigenetic repression and transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 220.127.116.11; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Molecular Function: chromatin binding; deacetylase activity; enzyme binding; heat shock protein binding; histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); NF-kappaB binding; nucleosomal DNA binding; protein binding; protein deacetylase activity; sequence-specific DNA binding; transcription factor binding
Biological Process: ATP-dependent chromatin remodeling; behavioral response to ethanol; blood coagulation; chromatin remodeling; circadian regulation of gene expression; dendrite development; embryonic digit morphogenesis; epidermal cell differentiation; establishment and/or maintenance of chromatin architecture; gene expression; histone deacetylation; maintenance of chromatin silencing; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of DNA binding; negative regulation of gene expression, epigenetic; negative regulation of MHC class II biosynthetic process; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of interleukin-1 production; positive regulation of oligodendrocyte differentiation; positive regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of gene expression, epigenetic; response to amphetamine; response to caffeine; response to cocaine; response to drug; response to hyperoxia; response to lipopolysaccharide; response to nicotine; transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.