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Protein Page:
5-HT(4) (human)

Overview
5-HT(4) This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 5q31-q33
Cellular Component: cytoplasm; endosome; integral to plasma membrane; membrane; plasma membrane
Molecular Function: serotonin receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; gamma-aminobutyric acid signaling pathway; regulation of appetite; serotonin receptor signaling pathway; synaptic transmission
Reference #:  Q13639 (UniProtKB)
Alt. Names/Synonyms: 5-HT-4; 5-HT4; 5-HT4R; 5-hydroxytryptamine (serotonin) receptor 4; 5-hydroxytryptamine receptor 4; 5-hydroxytryptamine4 receptor; 5HT4R; 5HTR4; cardiac 5-HT4 receptor; htr4; serotonin 5-HT4 receptor; serotonin receptor 4; Serotonin receptor 5-HT4
Gene Symbols: HTR4
Molecular weight: 43,761 Da
Basal Isoelectric point: 8.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

5-HT(4)

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S354‑p STTTINGstHVLRDA
0 1 T355‑p TTTINGstHVLRDAV
  mouse

 
S354 STTTINGSTHVLRDT
T355 TTTINGSTHVLRDTV
  rat

 
S354 STTTINGSTHVLRDT
T355 TTTINGSTHVLRDTV
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