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Protein Page:
VEGFB (human)

Overview
VEGFB Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Homodimer; disulfide-linked. Can also form heterodimer with VEGF. Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Cytokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Cell cycle regulation
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: extracellular region; extracellular space; membrane
Molecular Function: chemoattractant activity; growth factor activity; heparin binding; protein binding; protein heterodimerization activity; protein homodimerization activity; vascular endothelial growth factor receptor 1 binding
Biological Process: angiogenesis; blood coagulation; cardiac muscle contraction; induction of positive chemotaxis; negative regulation of apoptosis; negative regulation of neuron apoptosis; platelet activation; platelet degranulation; positive chemotaxis; positive regulation of cell division; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of vascular permeability; protein amino acid O-linked glycosylation; response to drug; vascular endothelial growth factor receptor signaling pathway
Reference #:  P49765 (UniProtKB)
Alt. Names/Synonyms: Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VEGFB; VEGFL; VRF
Gene Symbols: VEGFB
Molecular weight: 21,602 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VEGFB

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S24 APAQAPVSQPDAPGH
  mouse

 
S24 ARTQAPVSQFDGPSH
  rat

 
S24‑p ACTQAPVsQFDGPSH
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