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Protein Page:
MyoD (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MyoD a transcription factor of the basic helix-loop-helix family and the myogenic factors subfamily. Involved in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. It is involved in muscle cell differentiation, and is essential for repair of damaged tissue. It activates its own transcription which may stabilize commitment to myogenesis. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: cytoplasm; myofibril; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; chromatin DNA binding; nuclear hormone receptor binding; protein binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding
Biological Process: cellular response to starvation; muscle cell fate commitment; muscle development; myoblast cell fate determination; myoblast fusion; myotube cell development; myotube differentiation involved in skeletal muscle regeneration; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of skeletal muscle fiber development; positive regulation of skeletal muscle regeneration; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of RNA splicing; regulation of transcription from RNA polymerase II promoter; skeletal muscle development; skeletal muscle fiber adaptation; skeletal muscle fiber development; transcription from RNA polymerase II promoter
Reference #:  P15172 (UniProtKB)
Gene Symbols: MYOD1
Molecular weight: 34,501 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MyoD

Protein Structure Not Found.
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Sites Implicated In
activity, inhibited: T115‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S5 ___MELLSPPLRDVD
2 0 Y30 FATTDDFYDDPCFDS
1 0 K58‑ac MHVGALLkPEEHSHF
3 0 K99‑ac RCLLWACkACkRkTT
3 1 K102‑ac LWACkACkRkTTNAD
1 0 K104‑ac ACkACkRkTTNADRR
2 0 T115‑p ADRRKAAtMRERRRL
1 0 K133 NEAFETLKRCTSSNP
1 1 Y156 ILRNAIRYIEGLQAL
1 0 S200‑p YSGDSDAssPRsNCs
7 0 S201‑p SGDSDAssPRsNCsD
0 3 S204‑p SDAssPRsNCsDGMM
0 2 S207‑p ssPRsNCsDGMMDys
1 2 Y213‑p CsDGMMDysGPPSGA
0 2 S214‑p sDGMMDysGPPSGAR
1 0 P238 YNEAPSEPRPGKSAA
  mouse

 
S5‑p ___MELLsPPLRDID
Y30‑p FETADDFyDDPCFDS
K58 VHMGALLKPEEHAHF
K99‑ac RCLLWACkACkRKTT
K102‑ac LWACkACkRKTTNAD
K104 ACkACkRKTTNADRR
T115‑p ADRRKAAtMRERRRL
K133‑ub NEAFETLkRCTSSNP
Y156‑p ILRNAIRyIEGLQAL
S199 YSGDSDASsPRsNCS
S200‑p SGDSDASsPRsNCSD
S203‑p SDASsPRsNCSDGMM
S206 SsPRsNCSDGMMDyS
Y212‑p CSDGMMDySGPPSGP
S213 SDGMMDySGPPSGPR
S237‑p YSEAAREsRPGKSAA
  rat

 
S5 ___MELLSPPLRDTD
Y30 FATRDDFYDDPCFDS
K58 VHVGALLKPEEHAHF
K99 RCLLWACKACKRKTT
K102 LWACKACKRKTTNAD
K104 ACKACKRKTTNADRR
T115 ADRRKAATMRERRRL
K133 NEAFETLKRCTSSNP
Y156 ILRNAIRYIEGLQAL
S199 YSGDSDASSPRSNCS
S200 SGDSDASSPRSNCSD
S203 SDASSPRSNCSDGMM
S206 SSPRSNCSDGMMDYS
Y212 CSDGMMDYSGPPSGP
S213 SDGMMDYSGPPSGPR
P237 YSEASSEPRPGKSAA
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