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Protein Page:
syndecan-4 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
syndecan-4 a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 20q12
Cellular Component: cell surface; costamere; focal adhesion; Golgi lumen; integral to plasma membrane; lipid raft; lysosomal lumen; plasma membrane
Molecular Function: fibronectin binding; protein binding; protein kinase C binding
Biological Process: carbohydrate metabolic process; cell migration; chondroitin sulfate metabolic process; extracellular matrix organization and biogenesis; fat-soluble vitamin metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; inner ear receptor stereocilium organization and biogenesis; neural tube closure; phototransduction, visible light; positive regulation of focal adhesion formation; positive regulation of protein kinase activity; positive regulation of stress fiber formation; retinoid metabolic process; ureteric bud development; vitamin metabolic process; wound healing
Reference #:  P31431 (UniProtKB)
Alt. Names/Synonyms: Amphiglycan; MGC22217; ryudocan amphiglycan; Ryudocan core protein; SDC4; SYND4; syndecan 4; syndecan 4 (amphiglycan, ryudocan); syndecan proteoglycan 4; Syndecan-4
Gene Symbols: SDC4
Molecular weight: 21,642 Da
Basal Isoelectric point: 4.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

syndecan-4

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: S179‑p
cell cycle regulation: S179‑p
cytoskeletal reorganization: S179‑p
intracellular localization: S179‑p
molecular association, regulation: S179‑p, Y180‑p
protein processing: S179‑p
receptor recycling, altered: Y180‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S97‑ga PERAGSGsQVPtEPK
0 1 T101‑ga GSGsQVPtEPKKLEE
0 1 S117‑ga EVIPKRIsPVEESED
0 1 S126‑ga VEESEDVsNKVSMSS
0 1 T134‑p NKVSMSStVQGSNIF
8 0 S179‑p MKKKDEGsyDLGKKP
1 11 Y180‑p KKKDEGsyDLGKKPI
0 1 K190‑ub GKKPIYKkAPtNEFy
0 2 T193‑p PIYKkAPtNEFyA__
1 292 Y197‑p kAPtNEFyA______
  mouse

 
I98 PENAQPGIRVPSEPK
S102 QPGIRVPSEPKELEE
S119 VIPKRAPSDVGDDMS
S126 SDVGDDMSNKVSMSS
T134 NKVSMSSTAQGSNIF
S179‑p MKKKDEGsYDLGKKP
Y180 KKKDEGsYDLGKKPI
K190 GKKPIYKKAPTNEFy
T193 PIYKKAPTNEFyA__
Y197‑p KAPTNEFyA______
  rat

 
I101 PENAQPGIRVPSEPK
S105 QPGIRVPSEPKELEE
S122 VIPKRVPSDVGDDDV
S130 DVGDDDVSNKVSMSS
T138 NKVSMSSTSQGSNIF
S183‑p MKKKDEGsYDLGKKP
Y184 KKKDEGsYDLGKKPI
K194 GKKPIYKKAPTNEFy
T197 PIYKKAPTNEFyA__
Y201‑p KAPTNEFyA______
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